Association of endothelin-converting enzyme and endothelin-1 gene polymorphisms with essential hypertension in Malay ethnics
Objectives. Endothelin-1 (ET-1), the most potent endogenous vasoconstrictor, generated by enzymatic cleavage catalyzed by an endothelin-converting enzyme (ECE), plays a significant role in the regulation of hypertension. Methods. This study investigates the effect of endothelin-1 (Lys198Asn/rs5370)...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Published: |
Cambridge University Press
2022
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/100425/ |
| _version_ | 1848863320772182016 |
|---|---|
| author | Salim, Elnaz Ramachandran, Vasudevan Ansari, Neda Ismail, Patimah Mohamed, Mohd Hazmi Mohamad, Nur Afiqah Inche Mat, Liyana Najwa |
| author_facet | Salim, Elnaz Ramachandran, Vasudevan Ansari, Neda Ismail, Patimah Mohamed, Mohd Hazmi Mohamad, Nur Afiqah Inche Mat, Liyana Najwa |
| author_sort | Salim, Elnaz |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Objectives. Endothelin-1 (ET-1), the most potent endogenous vasoconstrictor, generated by enzymatic cleavage catalyzed by an endothelin-converting enzyme (ECE), plays a significant role in the regulation of hypertension. Methods. This study investigates the effect of endothelin-1 (Lys198Asn/rs5370) and ECE (rs212526 C/T) gene polymorphisms with essential hypertension (EH) among Malay ethnics. To determine the association of gene polymorphism, 177 hypertensives and controls (196) were genotyped using Taqman method. Results. A significant difference was observed in ET-1 rs5370 and ECE rs212526 gene polymorphisms between EH and control subjects (P < 0.001). A significantly high body mass index (BMI), waist-to-hip ratio, fasting plasma glucose, hemoglobin A1c, systolic and diastolic blood pressure, and lipid profiles were observed among the EH patients when compared to controls (P < 0.05). Moreover, T allele (rs5370) carriers in males have a high risk for EH. There was no significant association between gender in ECE C/T polymorphisms (P > 0.05). Conclusion. Based on our result, it is evident that the T allele of ET-1 rs5370 polymorphism and C allele of ECE rs212526 have a significant genetic risk factor in EH among Malay subjects, and BMI and age are associated with hypertension. |
| first_indexed | 2025-11-15T13:31:03Z |
| format | Article |
| id | upm-100425 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:31:03Z |
| publishDate | 2022 |
| publisher | Cambridge University Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1004252023-12-15T23:10:37Z http://psasir.upm.edu.my/id/eprint/100425/ Association of endothelin-converting enzyme and endothelin-1 gene polymorphisms with essential hypertension in Malay ethnics Salim, Elnaz Ramachandran, Vasudevan Ansari, Neda Ismail, Patimah Mohamed, Mohd Hazmi Mohamad, Nur Afiqah Inche Mat, Liyana Najwa Objectives. Endothelin-1 (ET-1), the most potent endogenous vasoconstrictor, generated by enzymatic cleavage catalyzed by an endothelin-converting enzyme (ECE), plays a significant role in the regulation of hypertension. Methods. This study investigates the effect of endothelin-1 (Lys198Asn/rs5370) and ECE (rs212526 C/T) gene polymorphisms with essential hypertension (EH) among Malay ethnics. To determine the association of gene polymorphism, 177 hypertensives and controls (196) were genotyped using Taqman method. Results. A significant difference was observed in ET-1 rs5370 and ECE rs212526 gene polymorphisms between EH and control subjects (P < 0.001). A significantly high body mass index (BMI), waist-to-hip ratio, fasting plasma glucose, hemoglobin A1c, systolic and diastolic blood pressure, and lipid profiles were observed among the EH patients when compared to controls (P < 0.05). Moreover, T allele (rs5370) carriers in males have a high risk for EH. There was no significant association between gender in ECE C/T polymorphisms (P > 0.05). Conclusion. Based on our result, it is evident that the T allele of ET-1 rs5370 polymorphism and C allele of ECE rs212526 have a significant genetic risk factor in EH among Malay subjects, and BMI and age are associated with hypertension. Cambridge University Press 2022-05-16 Article PeerReviewed Salim, Elnaz and Ramachandran, Vasudevan and Ansari, Neda and Ismail, Patimah and Mohamed, Mohd Hazmi and Mohamad, Nur Afiqah and Inche Mat, Liyana Najwa (2022) Association of endothelin-converting enzyme and endothelin-1 gene polymorphisms with essential hypertension in Malay ethnics. Genetics Research, 2022 (9129960). pp. 1-7. ISSN 1469-5073 https://www.hindawi.com/journals/gr/2022/9129960/ 10.1155/2022/9129960 |
| spellingShingle | Salim, Elnaz Ramachandran, Vasudevan Ansari, Neda Ismail, Patimah Mohamed, Mohd Hazmi Mohamad, Nur Afiqah Inche Mat, Liyana Najwa Association of endothelin-converting enzyme and endothelin-1 gene polymorphisms with essential hypertension in Malay ethnics |
| title | Association of endothelin-converting enzyme and endothelin-1 gene polymorphisms with essential hypertension in Malay ethnics |
| title_full | Association of endothelin-converting enzyme and endothelin-1 gene polymorphisms with essential hypertension in Malay ethnics |
| title_fullStr | Association of endothelin-converting enzyme and endothelin-1 gene polymorphisms with essential hypertension in Malay ethnics |
| title_full_unstemmed | Association of endothelin-converting enzyme and endothelin-1 gene polymorphisms with essential hypertension in Malay ethnics |
| title_short | Association of endothelin-converting enzyme and endothelin-1 gene polymorphisms with essential hypertension in Malay ethnics |
| title_sort | association of endothelin-converting enzyme and endothelin-1 gene polymorphisms with essential hypertension in malay ethnics |
| url | http://psasir.upm.edu.my/id/eprint/100425/ http://psasir.upm.edu.my/id/eprint/100425/ http://psasir.upm.edu.my/id/eprint/100425/ |