Assessment of Malaysian brown seaweed Padina gymnospora antioxidant properties and antimicrobial activity in different solvent extractions
The combination of a proton nuclear magnetic resonance (1H-NMR)-based metabolomics approach and principal component analysis (PCA) was used to differentiate variations of active metabolites in Padina gymnospora subjected to different extraction solvents. Their proximate composition and phytochemical...
| Main Authors: | , , , , , , , |
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| Format: | Article |
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Springer Japan
2022
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| Online Access: | http://psasir.upm.edu.my/id/eprint/100409/ |
| _version_ | 1848863317067563008 |
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| author | Nazarudin, Muhammad Farhan Shahidan, Muhammad Syazwan Noor Mazli, Nur Amirah Izyan Tan, Hui Teng Yam, Sim Khaw Md Yasin, Ina Salwany Isha, Azizul Paiko, Mohammed Aliyu |
| author_facet | Nazarudin, Muhammad Farhan Shahidan, Muhammad Syazwan Noor Mazli, Nur Amirah Izyan Tan, Hui Teng Yam, Sim Khaw Md Yasin, Ina Salwany Isha, Azizul Paiko, Mohammed Aliyu |
| author_sort | Nazarudin, Muhammad Farhan |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The combination of a proton nuclear magnetic resonance (1H-NMR)-based metabolomics approach and principal component analysis (PCA) was used to differentiate variations of active metabolites in Padina gymnospora subjected to different extraction solvents. Their proximate composition and phytochemical, antioxidant, and antimicrobial activity were also evaluated. A total of 13 metabolites were identified in the different solvents (polar, semipolar, and nonpolar) via 1H-NMR analysis. The present study demonstrated that P. gymnospora brown seaweed was rich in protein, lipid, and carbohydrates. Phytochemical investigation of the different P. gymnospora extracts revealed various secondary metabolites. The most abundant essential amino acid was leucine [5.79 ± 0.06 mg g−1 dry weight (DW)], and the most abundant nonessential amino acid was glutamic acid (8.62 ± 0.04 mg g−1 DW). The presence of metabolites such as alanine, N-phenylacetylphenylalanine, glutamic acid, 2-hydroxyisobutyric acid, sarcosine, and π-methylhistidine in the seaweed extracts was strongly correlated with their level of 2,2-diphenyl-1-picrylhydrazyl (DPPH) free-radical scavenging activity. P. gymnospora appeared to have antibacterial activity against Staphylococcus aureus (ATCC 43,300). The study also revealed P. gymnospora’s potential for use as a rich source of antioxidant agents, implying that commercial cultivation of this seaweed may be incentivized. |
| first_indexed | 2025-11-15T13:30:59Z |
| format | Article |
| id | upm-100409 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:30:59Z |
| publishDate | 2022 |
| publisher | Springer Japan |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1004092023-12-15T03:07:59Z http://psasir.upm.edu.my/id/eprint/100409/ Assessment of Malaysian brown seaweed Padina gymnospora antioxidant properties and antimicrobial activity in different solvent extractions Nazarudin, Muhammad Farhan Shahidan, Muhammad Syazwan Noor Mazli, Nur Amirah Izyan Tan, Hui Teng Yam, Sim Khaw Md Yasin, Ina Salwany Isha, Azizul Paiko, Mohammed Aliyu The combination of a proton nuclear magnetic resonance (1H-NMR)-based metabolomics approach and principal component analysis (PCA) was used to differentiate variations of active metabolites in Padina gymnospora subjected to different extraction solvents. Their proximate composition and phytochemical, antioxidant, and antimicrobial activity were also evaluated. A total of 13 metabolites were identified in the different solvents (polar, semipolar, and nonpolar) via 1H-NMR analysis. The present study demonstrated that P. gymnospora brown seaweed was rich in protein, lipid, and carbohydrates. Phytochemical investigation of the different P. gymnospora extracts revealed various secondary metabolites. The most abundant essential amino acid was leucine [5.79 ± 0.06 mg g−1 dry weight (DW)], and the most abundant nonessential amino acid was glutamic acid (8.62 ± 0.04 mg g−1 DW). The presence of metabolites such as alanine, N-phenylacetylphenylalanine, glutamic acid, 2-hydroxyisobutyric acid, sarcosine, and π-methylhistidine in the seaweed extracts was strongly correlated with their level of 2,2-diphenyl-1-picrylhydrazyl (DPPH) free-radical scavenging activity. P. gymnospora appeared to have antibacterial activity against Staphylococcus aureus (ATCC 43,300). The study also revealed P. gymnospora’s potential for use as a rich source of antioxidant agents, implying that commercial cultivation of this seaweed may be incentivized. Springer Japan 2022-06-16 Article PeerReviewed Nazarudin, Muhammad Farhan and Shahidan, Muhammad Syazwan and Noor Mazli, Nur Amirah Izyan and Tan, Hui Teng and Yam, Sim Khaw and Md Yasin, Ina Salwany and Isha, Azizul and Paiko, Mohammed Aliyu (2022) Assessment of Malaysian brown seaweed Padina gymnospora antioxidant properties and antimicrobial activity in different solvent extractions. Fisheries Science, 88. 493 - 507. ISSN 0919-9268; ESSN: 1444-2906 https://link.springer.com/article/10.1007/s12562-022-01606-0 10.1007/s12562-022-01606-0 |
| spellingShingle | Nazarudin, Muhammad Farhan Shahidan, Muhammad Syazwan Noor Mazli, Nur Amirah Izyan Tan, Hui Teng Yam, Sim Khaw Md Yasin, Ina Salwany Isha, Azizul Paiko, Mohammed Aliyu Assessment of Malaysian brown seaweed Padina gymnospora antioxidant properties and antimicrobial activity in different solvent extractions |
| title | Assessment of Malaysian brown seaweed Padina gymnospora antioxidant properties and antimicrobial activity in different solvent extractions |
| title_full | Assessment of Malaysian brown seaweed Padina gymnospora antioxidant properties and antimicrobial activity in different solvent extractions |
| title_fullStr | Assessment of Malaysian brown seaweed Padina gymnospora antioxidant properties and antimicrobial activity in different solvent extractions |
| title_full_unstemmed | Assessment of Malaysian brown seaweed Padina gymnospora antioxidant properties and antimicrobial activity in different solvent extractions |
| title_short | Assessment of Malaysian brown seaweed Padina gymnospora antioxidant properties and antimicrobial activity in different solvent extractions |
| title_sort | assessment of malaysian brown seaweed padina gymnospora antioxidant properties and antimicrobial activity in different solvent extractions |
| url | http://psasir.upm.edu.my/id/eprint/100409/ http://psasir.upm.edu.my/id/eprint/100409/ http://psasir.upm.edu.my/id/eprint/100409/ |