A preliminary nuclear magnetic resonance metabolomics study identifies metabolites that could serve as diagnostic markers of major depressive disorder
Background: The evaluation of metabolites that are directly involved in the physiological process, few steps short of phenotypical manifestation, remains vital for unravelling the biological moieties involved in the development of the (MDD) and in predicting its treatment outcome. Methodology: Eight...
| Main Authors: | , , , , , |
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| Format: | Article |
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Bentham Science Publishers
2022
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| Online Access: | http://psasir.upm.edu.my/id/eprint/100334/ |
| _version_ | 1848863297711898624 |
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| author | Mohammed Badamasi, Ibrahim Maulidiani, Maulidiani Munn, Sann Lye Ibrahim, Normala Shaari, Khozirah Stanslas, Johnson |
| author_facet | Mohammed Badamasi, Ibrahim Maulidiani, Maulidiani Munn, Sann Lye Ibrahim, Normala Shaari, Khozirah Stanslas, Johnson |
| author_sort | Mohammed Badamasi, Ibrahim |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Background: The evaluation of metabolites that are directly involved in the physiological process, few steps short of phenotypical manifestation, remains vital for unravelling the biological moieties involved in the development of the (MDD) and in predicting its treatment outcome. Methodology: Eight (8) urine and serum samples each obtained from consenting healthy controls (HC), twenty-five (25) urine and serum samples each from first episode treatment naïve MDD (TNMDD) patients, and twenty (22) urine and serum samples each s from treatment naïve MDD patients 2 weeks after SSRI treatment (TWMDD) were analysed for metabolites using proton nuclear magnetic resonance (1HNMR) spectroscopy. The evaluation of patients’ samples was carried out using Partial Least Squares Discriminant Analysis (PLS-DA) and Orthogonal Partial Least Square- Discriminant Analysis (OPLSDA) models.
Results: In the serum, decreased levels of lactate, glucose, glutamine, creatinine, acetate, valine, alanine, and fatty acid and an increased level of acetone and choline in TNMDD or TWMDD irrespective of whether an OPLSDA or PLSDA evaluation was used were identified. A test for statistical validations of these models was successful. Conclusion: Only some changes in serum metabolite levels between HC and TNMDD identified in this study have potential values in the diagnosis of MDD. These changes included decreased levels of lactate, glutamine, creatinine, valine, alanine, and fatty acid, as well as an increased level of acetone and choline in TNMDD. The diagnostic value of these changes in metabolites was maintained in samples from TWMDD patients, thus reaffirming the diagnostic nature of these metabolites for MDD. |
| first_indexed | 2025-11-15T13:30:41Z |
| format | Article |
| id | upm-100334 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:30:41Z |
| publishDate | 2022 |
| publisher | Bentham Science Publishers |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1003342024-01-29T04:38:04Z http://psasir.upm.edu.my/id/eprint/100334/ A preliminary nuclear magnetic resonance metabolomics study identifies metabolites that could serve as diagnostic markers of major depressive disorder Mohammed Badamasi, Ibrahim Maulidiani, Maulidiani Munn, Sann Lye Ibrahim, Normala Shaari, Khozirah Stanslas, Johnson Background: The evaluation of metabolites that are directly involved in the physiological process, few steps short of phenotypical manifestation, remains vital for unravelling the biological moieties involved in the development of the (MDD) and in predicting its treatment outcome. Methodology: Eight (8) urine and serum samples each obtained from consenting healthy controls (HC), twenty-five (25) urine and serum samples each from first episode treatment naïve MDD (TNMDD) patients, and twenty (22) urine and serum samples each s from treatment naïve MDD patients 2 weeks after SSRI treatment (TWMDD) were analysed for metabolites using proton nuclear magnetic resonance (1HNMR) spectroscopy. The evaluation of patients’ samples was carried out using Partial Least Squares Discriminant Analysis (PLS-DA) and Orthogonal Partial Least Square- Discriminant Analysis (OPLSDA) models. Results: In the serum, decreased levels of lactate, glucose, glutamine, creatinine, acetate, valine, alanine, and fatty acid and an increased level of acetone and choline in TNMDD or TWMDD irrespective of whether an OPLSDA or PLSDA evaluation was used were identified. A test for statistical validations of these models was successful. Conclusion: Only some changes in serum metabolite levels between HC and TNMDD identified in this study have potential values in the diagnosis of MDD. These changes included decreased levels of lactate, glutamine, creatinine, valine, alanine, and fatty acid, as well as an increased level of acetone and choline in TNMDD. The diagnostic value of these changes in metabolites was maintained in samples from TWMDD patients, thus reaffirming the diagnostic nature of these metabolites for MDD. Bentham Science Publishers 2022-03-14 Article PeerReviewed Mohammed Badamasi, Ibrahim and Maulidiani, Maulidiani and Munn, Sann Lye and Ibrahim, Normala and Shaari, Khozirah and Stanslas, Johnson (2022) A preliminary nuclear magnetic resonance metabolomics study identifies metabolites that could serve as diagnostic markers of major depressive disorder. Current Neuropharmacology, 20 (5). 965 - 982. ISSN 1570-159X; ESSN: 1875-6190 https://www.eurekaselect.com/article/116105 10.2174/1570159X19666210611095320 |
| spellingShingle | Mohammed Badamasi, Ibrahim Maulidiani, Maulidiani Munn, Sann Lye Ibrahim, Normala Shaari, Khozirah Stanslas, Johnson A preliminary nuclear magnetic resonance metabolomics study identifies metabolites that could serve as diagnostic markers of major depressive disorder |
| title | A preliminary nuclear magnetic resonance metabolomics study identifies metabolites that could serve as diagnostic markers of major depressive disorder |
| title_full | A preliminary nuclear magnetic resonance metabolomics study identifies metabolites that could serve as diagnostic markers of major depressive disorder |
| title_fullStr | A preliminary nuclear magnetic resonance metabolomics study identifies metabolites that could serve as diagnostic markers of major depressive disorder |
| title_full_unstemmed | A preliminary nuclear magnetic resonance metabolomics study identifies metabolites that could serve as diagnostic markers of major depressive disorder |
| title_short | A preliminary nuclear magnetic resonance metabolomics study identifies metabolites that could serve as diagnostic markers of major depressive disorder |
| title_sort | preliminary nuclear magnetic resonance metabolomics study identifies metabolites that could serve as diagnostic markers of major depressive disorder |
| url | http://psasir.upm.edu.my/id/eprint/100334/ http://psasir.upm.edu.my/id/eprint/100334/ http://psasir.upm.edu.my/id/eprint/100334/ |