Alginate-enabled green synthesis of S/Ag1.93S nanoparticles, their photothermal property and in-vitro assessment of their anti-skin-cancer effects augmented by a NIR laser
We report herein the design and synthesis of colloidally-stable S/Ag1.93S nanoparticles, their photothermal conversion properties and in vitro cytotoxicity toward A431 skin cancer cells under the excitation of a minimally-invasive 980 nm near-infrared (NIR) laser. Micron-sized S particles were first...
| Main Authors: | , , , , , , , |
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| Format: | Article |
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Elsevier
2022
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| Online Access: | http://psasir.upm.edu.my/id/eprint/100166/ |
| _version_ | 1848863251085918208 |
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| author | Wei, Chuen Yoong Chui, Fung Loke Joon, Ching Juan Yusoff, Khatijah Mohtarrudin, Norhafizah Tatsuma, Tetsu Ying, Xu Teck, Hock Lim |
| author_facet | Wei, Chuen Yoong Chui, Fung Loke Joon, Ching Juan Yusoff, Khatijah Mohtarrudin, Norhafizah Tatsuma, Tetsu Ying, Xu Teck, Hock Lim |
| author_sort | Wei, Chuen Yoong |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | We report herein the design and synthesis of colloidally-stable S/Ag1.93S nanoparticles, their photothermal conversion properties and in vitro cytotoxicity toward A431 skin cancer cells under the excitation of a minimally-invasive 980 nm near-infrared (NIR) laser. Micron-sized S particles were first synthesized via acidifying Na2S2O3 using biocompatible sodium alginate as a surfactant. In the presence of AgNO3 and under rapid microwave-induced heating, alginate reduced AgNO3 to nascent Ag which reacted with molten S in situ forming S/Ag1.93S nanoparticles. The nanoparticles were characterized using a combination of X-ray diffraction, electron microscopies, elemental analysis, zeta-potential analysis and UV–VIS-NIR spectroscopy. The average particles size was controlled between 40 and 60 nm by fixing the mole ratio of Ag+:S2O32−. When excited by a 980 nm laser, S/Ag1.93S nanoparticles (~40 nm) produced with the least amount of AgNO3 exhibited a respectable photothermal conversion efficiency of circa 62% with the test aqueous solution heated to a hyperthermia-inducing 52 °C in 15 min. At 0.7 W/cm2, the viability of A431 skin cancer cells incubated with 7.0 ± 0.2 μg/mL of S/Ag1.93S nanoparticles reduced to 14 ± 0.6%, while an A431 cell control maintained an 80% cell viability. These results suggested that S/Ag1.93S nanoparticles may have good potential in reducing metastatic skin carcinoma. |
| first_indexed | 2025-11-15T13:29:57Z |
| format | Article |
| id | upm-100166 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:29:57Z |
| publishDate | 2022 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1001662024-07-11T04:25:42Z http://psasir.upm.edu.my/id/eprint/100166/ Alginate-enabled green synthesis of S/Ag1.93S nanoparticles, their photothermal property and in-vitro assessment of their anti-skin-cancer effects augmented by a NIR laser Wei, Chuen Yoong Chui, Fung Loke Joon, Ching Juan Yusoff, Khatijah Mohtarrudin, Norhafizah Tatsuma, Tetsu Ying, Xu Teck, Hock Lim We report herein the design and synthesis of colloidally-stable S/Ag1.93S nanoparticles, their photothermal conversion properties and in vitro cytotoxicity toward A431 skin cancer cells under the excitation of a minimally-invasive 980 nm near-infrared (NIR) laser. Micron-sized S particles were first synthesized via acidifying Na2S2O3 using biocompatible sodium alginate as a surfactant. In the presence of AgNO3 and under rapid microwave-induced heating, alginate reduced AgNO3 to nascent Ag which reacted with molten S in situ forming S/Ag1.93S nanoparticles. The nanoparticles were characterized using a combination of X-ray diffraction, electron microscopies, elemental analysis, zeta-potential analysis and UV–VIS-NIR spectroscopy. The average particles size was controlled between 40 and 60 nm by fixing the mole ratio of Ag+:S2O32−. When excited by a 980 nm laser, S/Ag1.93S nanoparticles (~40 nm) produced with the least amount of AgNO3 exhibited a respectable photothermal conversion efficiency of circa 62% with the test aqueous solution heated to a hyperthermia-inducing 52 °C in 15 min. At 0.7 W/cm2, the viability of A431 skin cancer cells incubated with 7.0 ± 0.2 μg/mL of S/Ag1.93S nanoparticles reduced to 14 ± 0.6%, while an A431 cell control maintained an 80% cell viability. These results suggested that S/Ag1.93S nanoparticles may have good potential in reducing metastatic skin carcinoma. Elsevier 2022-03-15 Article PeerReviewed Wei, Chuen Yoong and Chui, Fung Loke and Joon, Ching Juan and Yusoff, Khatijah and Mohtarrudin, Norhafizah and Tatsuma, Tetsu and Ying, Xu and Teck, Hock Lim (2022) Alginate-enabled green synthesis of S/Ag1.93S nanoparticles, their photothermal property and in-vitro assessment of their anti-skin-cancer effects augmented by a NIR laser. International Journal of Biological Macromolecules, 201. 516 - 527. ISSN 0141-8130 https://www.sciencedirect.com/science/article/pii/S0141813022000782 10.1016/j.ijbiomac.2022.01.062 |
| spellingShingle | Wei, Chuen Yoong Chui, Fung Loke Joon, Ching Juan Yusoff, Khatijah Mohtarrudin, Norhafizah Tatsuma, Tetsu Ying, Xu Teck, Hock Lim Alginate-enabled green synthesis of S/Ag1.93S nanoparticles, their photothermal property and in-vitro assessment of their anti-skin-cancer effects augmented by a NIR laser |
| title | Alginate-enabled green synthesis of S/Ag1.93S nanoparticles, their photothermal property and in-vitro assessment of their anti-skin-cancer effects augmented by a NIR laser |
| title_full | Alginate-enabled green synthesis of S/Ag1.93S nanoparticles, their photothermal property and in-vitro assessment of their anti-skin-cancer effects augmented by a NIR laser |
| title_fullStr | Alginate-enabled green synthesis of S/Ag1.93S nanoparticles, their photothermal property and in-vitro assessment of their anti-skin-cancer effects augmented by a NIR laser |
| title_full_unstemmed | Alginate-enabled green synthesis of S/Ag1.93S nanoparticles, their photothermal property and in-vitro assessment of their anti-skin-cancer effects augmented by a NIR laser |
| title_short | Alginate-enabled green synthesis of S/Ag1.93S nanoparticles, their photothermal property and in-vitro assessment of their anti-skin-cancer effects augmented by a NIR laser |
| title_sort | alginate-enabled green synthesis of s/ag1.93s nanoparticles, their photothermal property and in-vitro assessment of their anti-skin-cancer effects augmented by a nir laser |
| url | http://psasir.upm.edu.my/id/eprint/100166/ http://psasir.upm.edu.my/id/eprint/100166/ http://psasir.upm.edu.my/id/eprint/100166/ |