Cytotoxic and Antioxidant Compounds from the Stem Bark of Goniothalamus tapisoides Mat Salleh
Eleven compounds: goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9 deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds...
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| Format: | Article |
| Language: | English |
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Molecules
2012
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| Online Access: | http://ir.unimas.my/id/eprint/97/ http://ir.unimas.my/id/eprint/97/1/Rosalind.pdf |
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| author | Rosalind Pei Theng, Kim Vicky, Bihud Khalit, Mohamad Kok Hoong, Leong Jamaludin, Mohamad Fasihuddin Badruddin, Ahmad Hazrina, Hazni Noraini, Kasim Siti Nadiah, Abdul Halim Khalijah, Awang |
| author_facet | Rosalind Pei Theng, Kim Vicky, Bihud Khalit, Mohamad Kok Hoong, Leong Jamaludin, Mohamad Fasihuddin Badruddin, Ahmad Hazrina, Hazni Noraini, Kasim Siti Nadiah, Abdul Halim Khalijah, Awang |
| author_sort | Rosalind Pei Theng, Kim |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Eleven compounds: goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9 deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data. Goniothalamin (6) exhibited mild cytotoxic activity towards a colon cancer cell line (HT-29), with an IC50 value of 64.17 ± 5.60 µM. Goniomicin B (2) give the highest antioxidant activity in the DPPH assay among all compounds tested, with an IC50 of 0.207 µM. |
| first_indexed | 2025-11-15T05:52:44Z |
| format | Article |
| id | unimas-97 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T05:52:44Z |
| publishDate | 2012 |
| publisher | Molecules |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-972023-03-29T03:26:59Z http://ir.unimas.my/id/eprint/97/ Cytotoxic and Antioxidant Compounds from the Stem Bark of Goniothalamus tapisoides Mat Salleh Rosalind Pei Theng, Kim Vicky, Bihud Khalit, Mohamad Kok Hoong, Leong Jamaludin, Mohamad Fasihuddin Badruddin, Ahmad Hazrina, Hazni Noraini, Kasim Siti Nadiah, Abdul Halim Khalijah, Awang AC Collections. Series. Collected works Eleven compounds: goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9 deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data. Goniothalamin (6) exhibited mild cytotoxic activity towards a colon cancer cell line (HT-29), with an IC50 value of 64.17 ± 5.60 µM. Goniomicin B (2) give the highest antioxidant activity in the DPPH assay among all compounds tested, with an IC50 of 0.207 µM. Molecules 2012-12-21 Article PeerReviewed text en http://ir.unimas.my/id/eprint/97/1/Rosalind.pdf Rosalind Pei Theng, Kim and Vicky, Bihud and Khalit, Mohamad and Kok Hoong, Leong and Jamaludin, Mohamad and Fasihuddin Badruddin, Ahmad and Hazrina, Hazni and Noraini, Kasim and Siti Nadiah, Abdul Halim and Khalijah, Awang (2012) Cytotoxic and Antioxidant Compounds from the Stem Bark of Goniothalamus tapisoides Mat Salleh. Molecules. pp. 128-139. ISSN 1420-3049 doi:10.3390/molecules18010128 |
| spellingShingle | AC Collections. Series. Collected works Rosalind Pei Theng, Kim Vicky, Bihud Khalit, Mohamad Kok Hoong, Leong Jamaludin, Mohamad Fasihuddin Badruddin, Ahmad Hazrina, Hazni Noraini, Kasim Siti Nadiah, Abdul Halim Khalijah, Awang Cytotoxic and Antioxidant Compounds from the Stem Bark of Goniothalamus tapisoides Mat Salleh |
| title | Cytotoxic and Antioxidant Compounds from the Stem Bark of Goniothalamus tapisoides Mat Salleh |
| title_full | Cytotoxic and Antioxidant Compounds from the Stem Bark of Goniothalamus tapisoides Mat Salleh |
| title_fullStr | Cytotoxic and Antioxidant Compounds from the Stem Bark of Goniothalamus tapisoides Mat Salleh |
| title_full_unstemmed | Cytotoxic and Antioxidant Compounds from the Stem Bark of Goniothalamus tapisoides Mat Salleh |
| title_short | Cytotoxic and Antioxidant Compounds from the Stem Bark of Goniothalamus tapisoides Mat Salleh |
| title_sort | cytotoxic and antioxidant compounds from the stem bark of goniothalamus tapisoides mat salleh |
| topic | AC Collections. Series. Collected works |
| url | http://ir.unimas.my/id/eprint/97/ http://ir.unimas.my/id/eprint/97/ http://ir.unimas.my/id/eprint/97/1/Rosalind.pdf |