Mechanism of Action of Camptothecin

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Mechanism of Action of Camptothecin

Camptothecin (CPT) class of compounds has been demonstrated to be effective against a broad spectrum of tumors. Their molecular target has been firmly established to be human DNA topoisomerase I (topo I). CPT inhibits topo I by blocking the rejoining step of the cleavage/religation reaction of topo-...

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Bibliographic Details
Main Authors:	Liu, L.F., Shyamal D., Desai, Li, Tsai-Kun, Mao, Yong, Mei, Sun, Sim, S.P
Format:	Article
Published:	Annals of the New York Academy of Sciences 2006
Subjects:	R Medicine (General)
Online Access:	http://ir.unimas.my/id/eprint/8233/

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