Inhibitor of caspase-activated DNase expression enhances caspase-activated DNase expression and inhibits oxidative stress-induced chromosome breaks at the mixed lineage leukaemia gene in nasopharyngeal carcinoma cells
Nasopharyngeal carcinoma (NPC) is commonly found in Asia, especially among the Chinese ethnic group. Chromosome rearrangements are common among NPC patients. Although the mechanism underlying the chromosome rearrangements in NPC is unclear, various mechanisms including activation of caspase-activate...
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BioMed Central
2015
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| Online Access: | http://ir.unimas.my/id/eprint/8231/ http://ir.unimas.my/id/eprint/8231/1/NO%2071%20Inhibitor%20of%20caspase-activated%20DNase%20expression%20enhances%20caspase-activated%20DNase%20expression%20and%20inhibits%20oxidative%20stress%20-%20abstrak.pdf |
| _version_ | 1848836330439573504 |
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| author | Siaw, Shi Boon Sim, S.P |
| author_facet | Siaw, Shi Boon Sim, S.P |
| author_sort | Siaw, Shi Boon |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Nasopharyngeal carcinoma (NPC) is commonly found in Asia, especially among the Chinese ethnic group. Chromosome rearrangements are common among NPC patients. Although the mechanism underlying the chromosome rearrangements in NPC is unclear, various mechanisms including activation of caspase-activated DNase (CAD) were proposed to contribute to chromosome rearrangements in leukaemia. Activation of CAD can be initiated by multiple agents, including oxidative stress, which is well implicated in carcinogenesis. CAD is the main enzyme that causes DNA fragmentation during apoptosis, and CAD is also implicated in promoting cell differentiation. In view of the role of oxidative stress in carcinogenesis and CAD activation, and since CAD was suggested to contribute to chromosome rearrangement in leukaemia, we hypothesise that oxidative stress-induced CAD activation could be one of the mechanisms that leads to chromosome rearrangements in NPC. |
| first_indexed | 2025-11-15T06:22:03Z |
| format | Article |
| id | unimas-8231 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:22:03Z |
| publishDate | 2015 |
| publisher | BioMed Central |
| recordtype | eprints |
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| spelling | unimas-82312017-02-06T07:32:17Z http://ir.unimas.my/id/eprint/8231/ Inhibitor of caspase-activated DNase expression enhances caspase-activated DNase expression and inhibits oxidative stress-induced chromosome breaks at the mixed lineage leukaemia gene in nasopharyngeal carcinoma cells Siaw, Shi Boon Sim, S.P R Medicine (General) Nasopharyngeal carcinoma (NPC) is commonly found in Asia, especially among the Chinese ethnic group. Chromosome rearrangements are common among NPC patients. Although the mechanism underlying the chromosome rearrangements in NPC is unclear, various mechanisms including activation of caspase-activated DNase (CAD) were proposed to contribute to chromosome rearrangements in leukaemia. Activation of CAD can be initiated by multiple agents, including oxidative stress, which is well implicated in carcinogenesis. CAD is the main enzyme that causes DNA fragmentation during apoptosis, and CAD is also implicated in promoting cell differentiation. In view of the role of oxidative stress in carcinogenesis and CAD activation, and since CAD was suggested to contribute to chromosome rearrangement in leukaemia, we hypothesise that oxidative stress-induced CAD activation could be one of the mechanisms that leads to chromosome rearrangements in NPC. BioMed Central 2015 Article PeerReviewed text en http://ir.unimas.my/id/eprint/8231/1/NO%2071%20Inhibitor%20of%20caspase-activated%20DNase%20expression%20enhances%20caspase-activated%20DNase%20expression%20and%20inhibits%20oxidative%20stress%20-%20abstrak.pdf Siaw, Shi Boon and Sim, S.P (2015) Inhibitor of caspase-activated DNase expression enhances caspase-activated DNase expression and inhibits oxidative stress-induced chromosome breaks at the mixed lineage leukaemia gene in nasopharyngeal carcinoma cells. Cancer Cell International, 15 (54). ISSN 1475-2867 http://www.cancerci.com/content/15/1/54 doi:10.1186/s12935-015-0205-1 |
| spellingShingle | R Medicine (General) Siaw, Shi Boon Sim, S.P Inhibitor of caspase-activated DNase expression enhances caspase-activated DNase expression and inhibits oxidative stress-induced chromosome breaks at the mixed lineage leukaemia gene in nasopharyngeal carcinoma cells |
| title | Inhibitor of caspase-activated DNase expression enhances caspase-activated DNase expression and inhibits oxidative stress-induced chromosome breaks at the mixed lineage leukaemia gene in nasopharyngeal carcinoma cells |
| title_full | Inhibitor of caspase-activated DNase expression enhances caspase-activated DNase expression and inhibits oxidative stress-induced chromosome breaks at the mixed lineage leukaemia gene in nasopharyngeal carcinoma cells |
| title_fullStr | Inhibitor of caspase-activated DNase expression enhances caspase-activated DNase expression and inhibits oxidative stress-induced chromosome breaks at the mixed lineage leukaemia gene in nasopharyngeal carcinoma cells |
| title_full_unstemmed | Inhibitor of caspase-activated DNase expression enhances caspase-activated DNase expression and inhibits oxidative stress-induced chromosome breaks at the mixed lineage leukaemia gene in nasopharyngeal carcinoma cells |
| title_short | Inhibitor of caspase-activated DNase expression enhances caspase-activated DNase expression and inhibits oxidative stress-induced chromosome breaks at the mixed lineage leukaemia gene in nasopharyngeal carcinoma cells |
| title_sort | inhibitor of caspase-activated dnase expression enhances caspase-activated dnase expression and inhibits oxidative stress-induced chromosome breaks at the mixed lineage leukaemia gene in nasopharyngeal carcinoma cells |
| topic | R Medicine (General) |
| url | http://ir.unimas.my/id/eprint/8231/ http://ir.unimas.my/id/eprint/8231/ http://ir.unimas.my/id/eprint/8231/ http://ir.unimas.my/id/eprint/8231/1/NO%2071%20Inhibitor%20of%20caspase-activated%20DNase%20expression%20enhances%20caspase-activated%20DNase%20expression%20and%20inhibits%20oxidative%20stress%20-%20abstrak.pdf |