Synthesis, characterization and antibacterial activity of bis thiourea derivatives
A series of bis(thiourea) derivatives were successfully synthesized by reaction of benzene-1,4-dicarbonyl isothiocyanate intermediates, with amino acid and aromatic amine to afford thiourea 20-24 with overall yields of 11–58%. The structures of the synthesized compounds were characterized by infra...
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| Format: | Final Year Project Report / IMRAD |
| Language: | English |
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Universiti Malaysia Sarawak, UNIMAS
2013
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| Online Access: | http://ir.unimas.my/id/eprint/7608/ http://ir.unimas.my/id/eprint/7608/8/Ainaa%20Nadiah%20Binti%20Abd%20Halim%20ft.pdf |
| _version_ | 1848836169731670016 |
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| author | Ainaa Nadiah, Abd Halim |
| author_facet | Ainaa Nadiah, Abd Halim |
| author_sort | Ainaa Nadiah, Abd Halim |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | A series of bis(thiourea) derivatives were successfully synthesized by reaction of benzene-1,4-dicarbonyl
isothiocyanate intermediates, with amino acid and aromatic amine to afford thiourea 20-24 with overall
yields of 11–58%. The structures of the synthesized compounds were characterized by infra red
spectroscopy (FTIR), 13C nuclear magnetic resonance (NMR), and 1H NMR spectroscopy. The
antibacterial activities of thiourea 20-24 were investigated on gram-negative bacteria, Escherichia coli
using turbidimetric kinetic method. Minimum inhibition concentration (MIC) values of the compounds
toward the bacteria were determined. The result obtained in this study indicated that only N1,N4-
bis(phenylcarbamothioyl)terephthalamide 22 showed antibacterial activity against E. coli compared with
other synthesized compounds. |
| first_indexed | 2025-11-15T06:19:30Z |
| format | Final Year Project Report / IMRAD |
| id | unimas-7608 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:19:30Z |
| publishDate | 2013 |
| publisher | Universiti Malaysia Sarawak, UNIMAS |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-76082024-02-27T08:21:44Z http://ir.unimas.my/id/eprint/7608/ Synthesis, characterization and antibacterial activity of bis thiourea derivatives Ainaa Nadiah, Abd Halim Q Science (General) QD Chemistry A series of bis(thiourea) derivatives were successfully synthesized by reaction of benzene-1,4-dicarbonyl isothiocyanate intermediates, with amino acid and aromatic amine to afford thiourea 20-24 with overall yields of 11–58%. The structures of the synthesized compounds were characterized by infra red spectroscopy (FTIR), 13C nuclear magnetic resonance (NMR), and 1H NMR spectroscopy. The antibacterial activities of thiourea 20-24 were investigated on gram-negative bacteria, Escherichia coli using turbidimetric kinetic method. Minimum inhibition concentration (MIC) values of the compounds toward the bacteria were determined. The result obtained in this study indicated that only N1,N4- bis(phenylcarbamothioyl)terephthalamide 22 showed antibacterial activity against E. coli compared with other synthesized compounds. Universiti Malaysia Sarawak, UNIMAS 2013 Final Year Project Report / IMRAD NonPeerReviewed text en http://ir.unimas.my/id/eprint/7608/8/Ainaa%20Nadiah%20Binti%20Abd%20Halim%20ft.pdf Ainaa Nadiah, Abd Halim (2013) Synthesis, characterization and antibacterial activity of bis thiourea derivatives. [Final Year Project Report / IMRAD] (Unpublished) |
| spellingShingle | Q Science (General) QD Chemistry Ainaa Nadiah, Abd Halim Synthesis, characterization and antibacterial activity of bis thiourea derivatives |
| title | Synthesis, characterization and antibacterial activity of bis thiourea derivatives |
| title_full | Synthesis, characterization and antibacterial activity of bis thiourea derivatives |
| title_fullStr | Synthesis, characterization and antibacterial activity of bis thiourea derivatives |
| title_full_unstemmed | Synthesis, characterization and antibacterial activity of bis thiourea derivatives |
| title_short | Synthesis, characterization and antibacterial activity of bis thiourea derivatives |
| title_sort | synthesis, characterization and antibacterial activity of bis thiourea derivatives |
| topic | Q Science (General) QD Chemistry |
| url | http://ir.unimas.my/id/eprint/7608/ http://ir.unimas.my/id/eprint/7608/8/Ainaa%20Nadiah%20Binti%20Abd%20Halim%20ft.pdf |