Risk modification of colorectal cancer susceptibility by interleukin-8 -251T>A polymorphism in Malaysians
AIM: To investigate the allele and genotype frequencies and associated risk of interleukin (IL )-8 -251T>A polymorphism on colorectal cancer (CRC) susceptibility risk. METHODS: Peripheral blood samples of 255 normal controls and 255 clinically and histopathologically confirmed CRC patients...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Baishideng
2012
|
| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/734/ http://ir.unimas.my/id/eprint/734/1/Risk%20modification%20of%20colorectal%20cancer%28abstract%29.pdf |
| _version_ | 1848834606599503872 |
|---|---|
| author | Mohd Aminudin, Mustapha Siti Nurfatimah, Mohd Shahpudin Ahmad Aizat, Abdul Aziz Ankathil, Ravindran |
| author_facet | Mohd Aminudin, Mustapha Siti Nurfatimah, Mohd Shahpudin Ahmad Aizat, Abdul Aziz Ankathil, Ravindran |
| author_sort | Mohd Aminudin, Mustapha |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | AIM: To investigate the allele and genotype frequencies
and associated risk of interleukin (IL )-8 -251T>A
polymorphism on colorectal cancer (CRC) susceptibility
risk.
METHODS: Peripheral blood samples of 255 normal
controls and 255 clinically and histopathologically confirmed
CRC patients were genotyped for IL-8 -251T>A
polymorphism employing allele-specific polymerase chain
reaction. The relative association of variant allele and
genotypes with CRC susceptibility risk was determined
by calculating the odds ratios (ORs). Corresponding χ
2
tests on the CRC patients and controls were carried out
and 95% confidence intervals (CIs) were determined
using Fisher’s exact test. The allele frequencies and its
risk association were calculated using FAMHAP, haplotype
association analysis software.
RESULTS: On comparing the frequencies of genotypes
of patients and controls, the homozygous variant AA
was significantly higher in CRC patients (P = 0.002)
compared to controls. Investigation on the association
of the polymorphic genotypes with CRC susceptibility
risk, showed that the homozygous variant IL-8 -251AA
had a significantly increased risk with OR 3.600 (95%
CI: 1.550-8.481, P = 0.001). In the case of allele frequencies,
variant allele A of IL-8 -251 showed a significantly
increased risk of CRC predisposition with OR 1.32
(95% CI: 1.03-1.69, P = 0.003).
CONCLUSION: Variant allele and genotype of IL-8 (-251
T>A) was significantly associated with CRC susceptibility
risk and could be considered as a high-risk variant
for CRC predisposition. |
| first_indexed | 2025-11-15T05:54:39Z |
| format | Article |
| id | unimas-734 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T05:54:39Z |
| publishDate | 2012 |
| publisher | Baishideng |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-7342015-09-10T07:34:08Z http://ir.unimas.my/id/eprint/734/ Risk modification of colorectal cancer susceptibility by interleukin-8 -251T>A polymorphism in Malaysians Mohd Aminudin, Mustapha Siti Nurfatimah, Mohd Shahpudin Ahmad Aizat, Abdul Aziz Ankathil, Ravindran Q Science (General) R Medicine (General) AIM: To investigate the allele and genotype frequencies and associated risk of interleukin (IL )-8 -251T>A polymorphism on colorectal cancer (CRC) susceptibility risk. METHODS: Peripheral blood samples of 255 normal controls and 255 clinically and histopathologically confirmed CRC patients were genotyped for IL-8 -251T>A polymorphism employing allele-specific polymerase chain reaction. The relative association of variant allele and genotypes with CRC susceptibility risk was determined by calculating the odds ratios (ORs). Corresponding χ 2 tests on the CRC patients and controls were carried out and 95% confidence intervals (CIs) were determined using Fisher’s exact test. The allele frequencies and its risk association were calculated using FAMHAP, haplotype association analysis software. RESULTS: On comparing the frequencies of genotypes of patients and controls, the homozygous variant AA was significantly higher in CRC patients (P = 0.002) compared to controls. Investigation on the association of the polymorphic genotypes with CRC susceptibility risk, showed that the homozygous variant IL-8 -251AA had a significantly increased risk with OR 3.600 (95% CI: 1.550-8.481, P = 0.001). In the case of allele frequencies, variant allele A of IL-8 -251 showed a significantly increased risk of CRC predisposition with OR 1.32 (95% CI: 1.03-1.69, P = 0.003). CONCLUSION: Variant allele and genotype of IL-8 (-251 T>A) was significantly associated with CRC susceptibility risk and could be considered as a high-risk variant for CRC predisposition. Baishideng 2012-06-07 Article NonPeerReviewed text en http://ir.unimas.my/id/eprint/734/1/Risk%20modification%20of%20colorectal%20cancer%28abstract%29.pdf Mohd Aminudin, Mustapha and Siti Nurfatimah, Mohd Shahpudin and Ahmad Aizat, Abdul Aziz and Ankathil, Ravindran (2012) Risk modification of colorectal cancer susceptibility by interleukin-8 -251T>A polymorphism in Malaysians. World Journal of Gastroenterology., 18 (21). pp. 2668-2673. ISSN 2219 - 2840 http://www.wjgnet.com/1007-9327/full/v18/i21/2668.htm doi:10.3748/wjg.v18.i21.2668 |
| spellingShingle | Q Science (General) R Medicine (General) Mohd Aminudin, Mustapha Siti Nurfatimah, Mohd Shahpudin Ahmad Aizat, Abdul Aziz Ankathil, Ravindran Risk modification of colorectal cancer susceptibility by interleukin-8 -251T>A polymorphism in Malaysians |
| title | Risk modification of colorectal cancer susceptibility by interleukin-8 -251T>A polymorphism in Malaysians |
| title_full | Risk modification of colorectal cancer susceptibility by interleukin-8 -251T>A polymorphism in Malaysians |
| title_fullStr | Risk modification of colorectal cancer susceptibility by interleukin-8 -251T>A polymorphism in Malaysians |
| title_full_unstemmed | Risk modification of colorectal cancer susceptibility by interleukin-8 -251T>A polymorphism in Malaysians |
| title_short | Risk modification of colorectal cancer susceptibility by interleukin-8 -251T>A polymorphism in Malaysians |
| title_sort | risk modification of colorectal cancer susceptibility by interleukin-8 -251t>a polymorphism in malaysians |
| topic | Q Science (General) R Medicine (General) |
| url | http://ir.unimas.my/id/eprint/734/ http://ir.unimas.my/id/eprint/734/ http://ir.unimas.my/id/eprint/734/ http://ir.unimas.my/id/eprint/734/1/Risk%20modification%20of%20colorectal%20cancer%28abstract%29.pdf |