Pathophysiologic and prognostic role of cytokines in dengue hemorrhagic fever.
Dengue shock syndrome is a severe complication of dengue hemorrhagic fever (DHF), characterized by a massive increase in vascular permeability. Plasma cytokine concentrations were prospectively studied in 443 Vietnamese children with DHF, of whom 6 died. Shock was present in 188 children on admissio...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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The University of Chicago
1998
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| Online Access: | http://ir.unimas.my/id/eprint/7035/ http://ir.unimas.my/id/eprint/7035/1/Pathophysiologic.pdf |
| _version_ | 1848836046240874496 |
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| author | Bethell, Delia B. Flobbe, Karin Phuong, Cao Xuan Thanh Day, Nicholas P.J. Phuong, Pham Tung Buurman, Wim A. Cardosa, Mary Jane White, Nicholas J. Kwiatkowski, Dominic |
| author_facet | Bethell, Delia B. Flobbe, Karin Phuong, Cao Xuan Thanh Day, Nicholas P.J. Phuong, Pham Tung Buurman, Wim A. Cardosa, Mary Jane White, Nicholas J. Kwiatkowski, Dominic |
| author_sort | Bethell, Delia B. |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Dengue shock syndrome is a severe complication of dengue hemorrhagic fever (DHF), characterized by a massive increase in vascular permeability. Plasma cytokine concentrations were prospectively studied in 443 Vietnamese children with DHF, of whom 6 died. Shock was present in 188 children on admission to hospital, and in 71 children it developed later. Contrary to expectations, certain inflammatory markers (interleukin-6 and soluble intercellular adhesion molecule-1) were lower in the group with shock, and this may reflect the general loss of protein from the circulation due to capillary leakage. Only soluble tumor necrosis factor receptor (TNFR) levels showed a
consistent positive relationship with disease severity. In patients with suspected DHF without shock, admission levels of sTNFR-75 in excess of 55 pg/mL predicted the subsequent development of shock, with a relative risk of 5.5 (95% confidence interval, 2.3–13.2). Large-scale release of soluble TNFR may be an early and specific marker of the endothelial changes that cause dengue shock syndrome. |
| first_indexed | 2025-11-15T06:17:32Z |
| format | Article |
| id | unimas-7035 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:17:32Z |
| publishDate | 1998 |
| publisher | The University of Chicago |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-70352022-01-19T01:00:03Z http://ir.unimas.my/id/eprint/7035/ Pathophysiologic and prognostic role of cytokines in dengue hemorrhagic fever. Bethell, Delia B. Flobbe, Karin Phuong, Cao Xuan Thanh Day, Nicholas P.J. Phuong, Pham Tung Buurman, Wim A. Cardosa, Mary Jane White, Nicholas J. Kwiatkowski, Dominic Q Science (General) QR355 Virology R Medicine (General) Dengue shock syndrome is a severe complication of dengue hemorrhagic fever (DHF), characterized by a massive increase in vascular permeability. Plasma cytokine concentrations were prospectively studied in 443 Vietnamese children with DHF, of whom 6 died. Shock was present in 188 children on admission to hospital, and in 71 children it developed later. Contrary to expectations, certain inflammatory markers (interleukin-6 and soluble intercellular adhesion molecule-1) were lower in the group with shock, and this may reflect the general loss of protein from the circulation due to capillary leakage. Only soluble tumor necrosis factor receptor (TNFR) levels showed a consistent positive relationship with disease severity. In patients with suspected DHF without shock, admission levels of sTNFR-75 in excess of 55 pg/mL predicted the subsequent development of shock, with a relative risk of 5.5 (95% confidence interval, 2.3–13.2). Large-scale release of soluble TNFR may be an early and specific marker of the endothelial changes that cause dengue shock syndrome. The University of Chicago 1998-03 Article PeerReviewed text en http://ir.unimas.my/id/eprint/7035/1/Pathophysiologic.pdf Bethell, Delia B. and Flobbe, Karin and Phuong, Cao Xuan Thanh and Day, Nicholas P.J. and Phuong, Pham Tung and Buurman, Wim A. and Cardosa, Mary Jane and White, Nicholas J. and Kwiatkowski, Dominic (1998) Pathophysiologic and prognostic role of cytokines in dengue hemorrhagic fever. The Journal of Infectious Diseases, 177 (3). pp. 778-782. ISSN 1537-6613 http://jid.oxfordjournals.org/content/177/3/778.abstract doi: 10.1086/517807 |
| spellingShingle | Q Science (General) QR355 Virology R Medicine (General) Bethell, Delia B. Flobbe, Karin Phuong, Cao Xuan Thanh Day, Nicholas P.J. Phuong, Pham Tung Buurman, Wim A. Cardosa, Mary Jane White, Nicholas J. Kwiatkowski, Dominic Pathophysiologic and prognostic role of cytokines in dengue hemorrhagic fever. |
| title | Pathophysiologic and prognostic role of cytokines in dengue hemorrhagic fever. |
| title_full | Pathophysiologic and prognostic role of cytokines in dengue hemorrhagic fever. |
| title_fullStr | Pathophysiologic and prognostic role of cytokines in dengue hemorrhagic fever. |
| title_full_unstemmed | Pathophysiologic and prognostic role of cytokines in dengue hemorrhagic fever. |
| title_short | Pathophysiologic and prognostic role of cytokines in dengue hemorrhagic fever. |
| title_sort | pathophysiologic and prognostic role of cytokines in dengue hemorrhagic fever. |
| topic | Q Science (General) QR355 Virology R Medicine (General) |
| url | http://ir.unimas.my/id/eprint/7035/ http://ir.unimas.my/id/eprint/7035/ http://ir.unimas.my/id/eprint/7035/ http://ir.unimas.my/id/eprint/7035/1/Pathophysiologic.pdf |