Virology, epidemiology, pathogenesis, and control of enterovirus 71.
First isolated in California, USA, in 1969, enterovirus 71 (EV71) is a major public health issue across the Asia-Pacific region and beyond. The virus, which is closely related to polioviruses, mostly affects children and causes hand, foot, and mouth disease with neurological and systemic complicatio...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English English |
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Science Direct
2010
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| Online Access: | http://ir.unimas.my/id/eprint/7025/ http://ir.unimas.my/id/eprint/7025/1/index.html_term%3D20961813 http://ir.unimas.my/id/eprint/7025/2/Solomon.pdf |
| _version_ | 1848836043939250176 |
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| author | Solomon, Tom Lewthwaite, Penny Perera, David Cardosa, Mary Jane McMinn, P.C Ooi, Mong How |
| author_facet | Solomon, Tom Lewthwaite, Penny Perera, David Cardosa, Mary Jane McMinn, P.C Ooi, Mong How |
| author_sort | Solomon, Tom |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | First isolated in California, USA, in 1969, enterovirus 71 (EV71) is a major public health issue across the Asia-Pacific region and beyond. The virus, which is closely related to polioviruses, mostly affects children and causes hand, foot, and mouth disease with neurological and systemic complications. Specific receptors for this virus are found on white blood cells, cells in the respiratory and gastrointestinal tract, and dendritic cells. Being an RNA virus, EV71 lacks a proofreading mechanism and is evolving rapidly, with new outbreaks occurring across Asia in regular cycles, and virus gene subgroups seem to differ in clinical epidemiological properties. The pathogenesis of the severe cardiopulmonary manifestations and the relative contributions of neurogenic pulmonary oedema, cardiac dysfunction, increased vascular permeability, and cytokine storm are controversial. Public health interventions to control outbreaks involve social distancing measures, but their effectiveness has not been fully assessed. Vaccines being developed include inactivated whole-virus, live attenuated, subviral particle, and DNA vaccines. |
| first_indexed | 2025-11-15T06:17:30Z |
| format | Article |
| id | unimas-7025 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T06:17:30Z |
| publishDate | 2010 |
| publisher | Science Direct |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-70252021-07-05T15:08:02Z http://ir.unimas.my/id/eprint/7025/ Virology, epidemiology, pathogenesis, and control of enterovirus 71. Solomon, Tom Lewthwaite, Penny Perera, David Cardosa, Mary Jane McMinn, P.C Ooi, Mong How Q Science (General) QR355 Virology R Medicine (General) First isolated in California, USA, in 1969, enterovirus 71 (EV71) is a major public health issue across the Asia-Pacific region and beyond. The virus, which is closely related to polioviruses, mostly affects children and causes hand, foot, and mouth disease with neurological and systemic complications. Specific receptors for this virus are found on white blood cells, cells in the respiratory and gastrointestinal tract, and dendritic cells. Being an RNA virus, EV71 lacks a proofreading mechanism and is evolving rapidly, with new outbreaks occurring across Asia in regular cycles, and virus gene subgroups seem to differ in clinical epidemiological properties. The pathogenesis of the severe cardiopulmonary manifestations and the relative contributions of neurogenic pulmonary oedema, cardiac dysfunction, increased vascular permeability, and cytokine storm are controversial. Public health interventions to control outbreaks involve social distancing measures, but their effectiveness has not been fully assessed. Vaccines being developed include inactivated whole-virus, live attenuated, subviral particle, and DNA vaccines. Science Direct 2010-10 Article PeerReviewed text en http://ir.unimas.my/id/eprint/7025/1/index.html_term%3D20961813 text en http://ir.unimas.my/id/eprint/7025/2/Solomon.pdf Solomon, Tom and Lewthwaite, Penny and Perera, David and Cardosa, Mary Jane and McMinn, P.C and Ooi, Mong How (2010) Virology, epidemiology, pathogenesis, and control of enterovirus 71. The Lancet Infectious Diseases, 10 (11). pp. 778-790. ISSN 1473-3099 http://www.sciencedirect.com/science/article/pii/S1473309910701948 DOI:10.1016/S1473- 3099(10)70194-8 |
| spellingShingle | Q Science (General) QR355 Virology R Medicine (General) Solomon, Tom Lewthwaite, Penny Perera, David Cardosa, Mary Jane McMinn, P.C Ooi, Mong How Virology, epidemiology, pathogenesis, and control of enterovirus 71. |
| title | Virology, epidemiology, pathogenesis, and control of enterovirus 71. |
| title_full | Virology, epidemiology, pathogenesis, and control of enterovirus 71. |
| title_fullStr | Virology, epidemiology, pathogenesis, and control of enterovirus 71. |
| title_full_unstemmed | Virology, epidemiology, pathogenesis, and control of enterovirus 71. |
| title_short | Virology, epidemiology, pathogenesis, and control of enterovirus 71. |
| title_sort | virology, epidemiology, pathogenesis, and control of enterovirus 71. |
| topic | Q Science (General) QR355 Virology R Medicine (General) |
| url | http://ir.unimas.my/id/eprint/7025/ http://ir.unimas.my/id/eprint/7025/ http://ir.unimas.my/id/eprint/7025/ http://ir.unimas.my/id/eprint/7025/1/index.html_term%3D20961813 http://ir.unimas.my/id/eprint/7025/2/Solomon.pdf |