Clinical features, diagnosis, and management of enterovirus 71
Although poliomyelitis has been mostly eradicated worldwide, large outbreaks of the related enterovirus 71 have been seen in Asia-Pacific countries in the past 10 years. This virus mostly affects children, manifesting as hand, foot, and mouth disease, aseptic meningitis, poliomyelitis-like acute fla...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Science Direct
2010
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| Online Access: | http://ir.unimas.my/id/eprint/7019/ http://ir.unimas.my/id/eprint/7019/2/Clinical%20features.pdf |
| _version_ | 1848836042156670976 |
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| author | Ooi, Mong How Wong, See Chang Lewthwaite, Penny Cardosa, Mary Jane Solomon, Tom |
| author_facet | Ooi, Mong How Wong, See Chang Lewthwaite, Penny Cardosa, Mary Jane Solomon, Tom |
| author_sort | Ooi, Mong How |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Although poliomyelitis has been mostly eradicated worldwide, large outbreaks of the related enterovirus 71 have been seen in Asia-Pacific countries in the past 10 years. This virus mostly affects children, manifesting as hand, foot, and mouth disease, aseptic meningitis, poliomyelitis-like acute flaccid paralysis, brainstem encephalitis, and other severe systemic disorders, including especially pulmonary oedema and cardiorespiratory collapse. Clinical predictors of severe disease include high temperature and lethargy, and lumbar puncture might reveal pleocytosis. Many diagnostic tests are available, but PCR of throat swabs and vesicle fluid, if available, is among the most efficient. Features of inflammation, particularly in the anterior horns of the spinal cord, the dorsal pons, and the medulla can be clearly seen on MRI. No established antiviral treatment is available. Intravenous immunoglobulin seems to be beneficial in severe disease, perhaps through non-specific anti-inflammatory mechanisms, but has not been tested in any formal trials. Milrinone might be helpful in patients with cardiac dysfunction. |
| first_indexed | 2025-11-15T06:17:28Z |
| format | Article |
| id | unimas-7019 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:17:28Z |
| publishDate | 2010 |
| publisher | Science Direct |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-70192022-09-05T01:56:31Z http://ir.unimas.my/id/eprint/7019/ Clinical features, diagnosis, and management of enterovirus 71 Ooi, Mong How Wong, See Chang Lewthwaite, Penny Cardosa, Mary Jane Solomon, Tom Q Science (General) QR355 Virology R Medicine (General) Although poliomyelitis has been mostly eradicated worldwide, large outbreaks of the related enterovirus 71 have been seen in Asia-Pacific countries in the past 10 years. This virus mostly affects children, manifesting as hand, foot, and mouth disease, aseptic meningitis, poliomyelitis-like acute flaccid paralysis, brainstem encephalitis, and other severe systemic disorders, including especially pulmonary oedema and cardiorespiratory collapse. Clinical predictors of severe disease include high temperature and lethargy, and lumbar puncture might reveal pleocytosis. Many diagnostic tests are available, but PCR of throat swabs and vesicle fluid, if available, is among the most efficient. Features of inflammation, particularly in the anterior horns of the spinal cord, the dorsal pons, and the medulla can be clearly seen on MRI. No established antiviral treatment is available. Intravenous immunoglobulin seems to be beneficial in severe disease, perhaps through non-specific anti-inflammatory mechanisms, but has not been tested in any formal trials. Milrinone might be helpful in patients with cardiac dysfunction. Science Direct 2010-11 Article PeerReviewed text en http://ir.unimas.my/id/eprint/7019/2/Clinical%20features.pdf Ooi, Mong How and Wong, See Chang and Lewthwaite, Penny and Cardosa, Mary Jane and Solomon, Tom (2010) Clinical features, diagnosis, and management of enterovirus 71. The Lancet Neurology, 9 (11). pp. 1097-1105. ISSN 1474-4422 http://www.sciencedirect.com/science/article/pii/S147444221070209X doi:10.1016/S1474-4422(10)70209-X |
| spellingShingle | Q Science (General) QR355 Virology R Medicine (General) Ooi, Mong How Wong, See Chang Lewthwaite, Penny Cardosa, Mary Jane Solomon, Tom Clinical features, diagnosis, and management of enterovirus 71 |
| title | Clinical features, diagnosis, and management of enterovirus 71 |
| title_full | Clinical features, diagnosis, and management of enterovirus 71 |
| title_fullStr | Clinical features, diagnosis, and management of enterovirus 71 |
| title_full_unstemmed | Clinical features, diagnosis, and management of enterovirus 71 |
| title_short | Clinical features, diagnosis, and management of enterovirus 71 |
| title_sort | clinical features, diagnosis, and management of enterovirus 71 |
| topic | Q Science (General) QR355 Virology R Medicine (General) |
| url | http://ir.unimas.my/id/eprint/7019/ http://ir.unimas.my/id/eprint/7019/ http://ir.unimas.my/id/eprint/7019/ http://ir.unimas.my/id/eprint/7019/2/Clinical%20features.pdf |