Letter to the Editor : Sylvatic Dengue Viruses Share the Pathogenic Potential of Urban/Endemic Dengue Viruses
Dengue virus (DENV) exists in both sylvatic and urban/endemic ecotypes (15), and the potential for emergence of sylvatic strains has become a focus of research. Recently Mota and Rico-Hesse (10) attempted to evaluate the pathogenic potential of viruses belonging to different genetic subgroups of DEN...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
American Society for Microbiology
2010
|
| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/6976/ http://ir.unimas.my/id/eprint/6976/1/Sylvatic%20Dengue%20Viruses%20Share%20the%20Pathogenic%20Potential%20of%20Urban%20Endemic%20Dengue%20Viruses%20%28abstract%29.pdf |
| _version_ | 1848836036015161344 |
|---|---|
| author | Vasilakis, Nikos Cardosa, Mary Jane Sall, Amadou A. Diallo, Mawlouth Holmes, Edward C. Hanley, Kathryn A. Weaver, Scott C. |
| author_facet | Vasilakis, Nikos Cardosa, Mary Jane Sall, Amadou A. Diallo, Mawlouth Holmes, Edward C. Hanley, Kathryn A. Weaver, Scott C. |
| author_sort | Vasilakis, Nikos |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Dengue virus (DENV) exists in both sylvatic and urban/endemic ecotypes (15), and the potential for emergence of sylvatic strains has become a focus of research. Recently Mota and Rico-Hesse (10) attempted to evaluate the pathogenic potential of viruses belonging to different genetic subgroups of DENV serotype 2 (DENV-2). Based on the viremia levels and erythema index profiles of one sylvatic genotype and three (Asian, American, and Indian) urban/endemic genotypes evaluated using the NOD-scid IL2rγnull humanized mouse model, the authors concluded that sylvatic DENV-2 viruses possess a reduced pathogenic potential compared to strains belonging to urban/endemic DENV-2 genotypes. However, these conclusions ignore both patterns in their own data and a wealth of published ex vivo, in vivo, and epidemiological evidence collected over the past 40 years. |
| first_indexed | 2025-11-15T06:17:22Z |
| format | Article |
| id | unimas-6976 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:17:22Z |
| publishDate | 2010 |
| publisher | American Society for Microbiology |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-69762015-04-10T03:48:34Z http://ir.unimas.my/id/eprint/6976/ Letter to the Editor : Sylvatic Dengue Viruses Share the Pathogenic Potential of Urban/Endemic Dengue Viruses Vasilakis, Nikos Cardosa, Mary Jane Sall, Amadou A. Diallo, Mawlouth Holmes, Edward C. Hanley, Kathryn A. Weaver, Scott C. Q Science (General) QR355 Virology R Medicine (General) Dengue virus (DENV) exists in both sylvatic and urban/endemic ecotypes (15), and the potential for emergence of sylvatic strains has become a focus of research. Recently Mota and Rico-Hesse (10) attempted to evaluate the pathogenic potential of viruses belonging to different genetic subgroups of DENV serotype 2 (DENV-2). Based on the viremia levels and erythema index profiles of one sylvatic genotype and three (Asian, American, and Indian) urban/endemic genotypes evaluated using the NOD-scid IL2rγnull humanized mouse model, the authors concluded that sylvatic DENV-2 viruses possess a reduced pathogenic potential compared to strains belonging to urban/endemic DENV-2 genotypes. However, these conclusions ignore both patterns in their own data and a wealth of published ex vivo, in vivo, and epidemiological evidence collected over the past 40 years. American Society for Microbiology 2010-04 Article PeerReviewed text en http://ir.unimas.my/id/eprint/6976/1/Sylvatic%20Dengue%20Viruses%20Share%20the%20Pathogenic%20Potential%20of%20Urban%20Endemic%20Dengue%20Viruses%20%28abstract%29.pdf Vasilakis, Nikos and Cardosa, Mary Jane and Sall, Amadou A. and Diallo, Mawlouth and Holmes, Edward C. and Hanley, Kathryn A. and Weaver, Scott C. (2010) Letter to the Editor : Sylvatic Dengue Viruses Share the Pathogenic Potential of Urban/Endemic Dengue Viruses. Journal Of Virology, 84 (7). pp. 3726-3728. ISSN 0022-538X http://jvi.asm.org/content/84/7/3726.full.pdf+html |
| spellingShingle | Q Science (General) QR355 Virology R Medicine (General) Vasilakis, Nikos Cardosa, Mary Jane Sall, Amadou A. Diallo, Mawlouth Holmes, Edward C. Hanley, Kathryn A. Weaver, Scott C. Letter to the Editor : Sylvatic Dengue Viruses Share the Pathogenic Potential of Urban/Endemic Dengue Viruses |
| title | Letter to the Editor : Sylvatic Dengue Viruses Share the Pathogenic Potential of Urban/Endemic Dengue Viruses |
| title_full | Letter to the Editor : Sylvatic Dengue Viruses Share the Pathogenic Potential of Urban/Endemic Dengue Viruses |
| title_fullStr | Letter to the Editor : Sylvatic Dengue Viruses Share the Pathogenic Potential of Urban/Endemic Dengue Viruses |
| title_full_unstemmed | Letter to the Editor : Sylvatic Dengue Viruses Share the Pathogenic Potential of Urban/Endemic Dengue Viruses |
| title_short | Letter to the Editor : Sylvatic Dengue Viruses Share the Pathogenic Potential of Urban/Endemic Dengue Viruses |
| title_sort | letter to the editor : sylvatic dengue viruses share the pathogenic potential of urban/endemic dengue viruses |
| topic | Q Science (General) QR355 Virology R Medicine (General) |
| url | http://ir.unimas.my/id/eprint/6976/ http://ir.unimas.my/id/eprint/6976/ http://ir.unimas.my/id/eprint/6976/1/Sylvatic%20Dengue%20Viruses%20Share%20the%20Pathogenic%20Potential%20of%20Urban%20Endemic%20Dengue%20Viruses%20%28abstract%29.pdf |