Letter to the Editor : Sylvatic Dengue Viruses Share the Pathogenic Potential of Urban/Endemic Dengue Viruses
Dengue virus (DENV) exists in both sylvatic and urban/endemic ecotypes (15), and the potential for emergence of sylvatic strains has become a focus of research. Recently Mota and Rico-Hesse (10) attempted to evaluate the pathogenic potential of viruses belonging to different genetic subgroups of DEN...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Society for Microbiology
2010
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/6976/ http://ir.unimas.my/id/eprint/6976/1/Sylvatic%20Dengue%20Viruses%20Share%20the%20Pathogenic%20Potential%20of%20Urban%20Endemic%20Dengue%20Viruses%20%28abstract%29.pdf |
| Summary: | Dengue virus (DENV) exists in both sylvatic and urban/endemic ecotypes (15), and the potential for emergence of sylvatic strains has become a focus of research. Recently Mota and Rico-Hesse (10) attempted to evaluate the pathogenic potential of viruses belonging to different genetic subgroups of DENV serotype 2 (DENV-2). Based on the viremia levels and erythema index profiles of one sylvatic genotype and three (Asian, American, and Indian) urban/endemic genotypes evaluated using the NOD-scid IL2rĪ³null humanized mouse model, the authors concluded that sylvatic DENV-2 viruses possess a reduced pathogenic potential compared to strains belonging to urban/endemic DENV-2 genotypes. However, these conclusions ignore both patterns in their own data and a wealth of published ex vivo, in vivo, and epidemiological evidence collected over the past 40 years. |
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