Phytochemical studies and biological activities of goniothalamus malayanus
The Phytochemical studies and biological activities of Goniothalamus malayanus have been conducted. The roots and stem barks of Goniothalamus malayanus were extracted with methanol and yield 13.08 g (1.31%) and 12.85 (0.71%) crude extract respectively. The methanol crude extract for both parts we...
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| Format: | Final Year Project Report / IMRAD |
| Language: | English |
| Published: |
Universiti Malaysia Sarawak, (UNIMAS)
2011
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/6430/ http://ir.unimas.my/id/eprint/6430/4/Siti%20Awanis%28fulltext%29.pdf |
| Summary: | The Phytochemical studies and biological activities of Goniothalamus malayanus have been
conducted. The roots and stem barks of Goniothalamus malayanus were extracted with
methanol and yield 13.08 g (1.31%) and 12.85 (0.71%) crude extract respectively. The
methanol crude extract for both parts were partitioned using solvent with increasing polarity in
the order of hexane, dichloromethane, chloroform and ethyl acetate. Ethyl acetate crude
extract of the roots and DCM crude extract of the stem barks were subjected to column
chromatography. For purification process, extensive column chromatography of the extracts
gave one pure compound from the roots which was labeled as GMEtOAc7 and one semi pure
compound from the stem barks and labeled as GMDCM6.7. Both compounds were subjected
to various spectroscopic analyses such as IR, MS and NMR to elucidate the structure. Based
on spectroscopic information, the compound isolated from both fractions was identified as
goniothalamin. Ethyl acetate crude extract from the roots was toxic against Artemia salina
which gave LC50 of 33.89 μg/mL while for the stem barks sample, dichloromethane crude
extract was toxic against Artemia salina which gave LC50 value of 50.12 μg/mL. Ethyl acetate
crude extract from roots of Goniothalamus malayanus was the most toxic against Coptotermes
sp. that showed LC50 value of 1.50%. While for the stem barks of Goniothalamus malayanus,
DCM crude extract was the most toxic against Coptotermes sp. that gave LC50value of 0.17%. |
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