Synthesis, spectral studies and cytotoxicity of organotin(IV) complexes with hydrazone ligands
Eight new organotin(IV) complexes of 2-hydroxy-3-methoxybenzaldehyde isonicotinylhydrazone [L1 (1)] with general formula [RnSnCl3-n (L1)] [ R = Me, n = 2 (3); R = Bu, n = 2 (4); R = Ph, n = 2 (5); R = Me, n = 1 (6); R = Bu, n = 1 (7); R= Ph, n= 1 (8)] were synthesized by direct reaction of the liga...
| Main Author: | |
|---|---|
| Format: | Final Year Project Report / IMRAD |
| Language: | English |
| Published: |
Universiti Malaysia Sarawak, UNIMAS
2012
|
| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/6272/ http://ir.unimas.my/id/eprint/6272/4/NUR%20HAFIZAH%20BT%20RAMLI%20ft.pdf |
| _version_ | 1848835880738881536 |
|---|---|
| author | Nur Hafizah, bt Ramli |
| author_facet | Nur Hafizah, bt Ramli |
| author_sort | Nur Hafizah, bt Ramli |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Eight new organotin(IV) complexes of 2-hydroxy-3-methoxybenzaldehyde isonicotinylhydrazone [L1 (1)] with general formula [RnSnCl3-n (L1)] [ R = Me, n = 2 (3); R =
Bu, n = 2 (4); R = Ph, n = 2 (5); R = Me, n = 1 (6); R = Bu, n = 1 (7); R= Ph, n= 1 (8)] were synthesized by direct reaction of the ligand (1), base and organotin(IV) chloride(s) in absolute methanol under N2 atmosphere. Another four organotin(IV) complexes of paminoacetophenone isonicotinylhydrazone [L2 (2)] with general formula [RnSnCl3-n] [ R = Me, n = 2 (9); R = Bu, n = 2 (10); R = Me, n = 1 (11); R = Ph, n = 1 (12)] were also synthesized by direct reaction of the ligand (2), base and organotin(IV) chloride(s). The ligands (1-2) and their organotin(IV) complexes (3-12) have been characterized by elemental analyses, UV-Visible, FT-IR and 1H NMR spectral studies. Spectroscopic data suggested that ligand (1) acted as a dinegative tridentate and ligand (2) acted as uninegative bidentate chelating agent. The toxicity of the hydrazone ligands (1-2) and their selected organotin(IV) complexes were evaluated against Artemia salina. The results shown that the selected organotin(IV) complexes have better cytotoxicity than the free ligands (1-2). Furthermore, it has been shown that diphenyltin(IV) complex exhibit significantly better activity than the other organotin derivatives. |
| first_indexed | 2025-11-15T06:14:54Z |
| format | Final Year Project Report / IMRAD |
| id | unimas-6272 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:14:54Z |
| publishDate | 2012 |
| publisher | Universiti Malaysia Sarawak, UNIMAS |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-62722023-11-20T08:01:48Z http://ir.unimas.my/id/eprint/6272/ Synthesis, spectral studies and cytotoxicity of organotin(IV) complexes with hydrazone ligands Nur Hafizah, bt Ramli Q Science (General) QD Chemistry Eight new organotin(IV) complexes of 2-hydroxy-3-methoxybenzaldehyde isonicotinylhydrazone [L1 (1)] with general formula [RnSnCl3-n (L1)] [ R = Me, n = 2 (3); R = Bu, n = 2 (4); R = Ph, n = 2 (5); R = Me, n = 1 (6); R = Bu, n = 1 (7); R= Ph, n= 1 (8)] were synthesized by direct reaction of the ligand (1), base and organotin(IV) chloride(s) in absolute methanol under N2 atmosphere. Another four organotin(IV) complexes of paminoacetophenone isonicotinylhydrazone [L2 (2)] with general formula [RnSnCl3-n] [ R = Me, n = 2 (9); R = Bu, n = 2 (10); R = Me, n = 1 (11); R = Ph, n = 1 (12)] were also synthesized by direct reaction of the ligand (2), base and organotin(IV) chloride(s). The ligands (1-2) and their organotin(IV) complexes (3-12) have been characterized by elemental analyses, UV-Visible, FT-IR and 1H NMR spectral studies. Spectroscopic data suggested that ligand (1) acted as a dinegative tridentate and ligand (2) acted as uninegative bidentate chelating agent. The toxicity of the hydrazone ligands (1-2) and their selected organotin(IV) complexes were evaluated against Artemia salina. The results shown that the selected organotin(IV) complexes have better cytotoxicity than the free ligands (1-2). Furthermore, it has been shown that diphenyltin(IV) complex exhibit significantly better activity than the other organotin derivatives. Universiti Malaysia Sarawak, UNIMAS 2012 Final Year Project Report / IMRAD NonPeerReviewed text en http://ir.unimas.my/id/eprint/6272/4/NUR%20HAFIZAH%20BT%20RAMLI%20ft.pdf Nur Hafizah, bt Ramli (2012) Synthesis, spectral studies and cytotoxicity of organotin(IV) complexes with hydrazone ligands. [Final Year Project Report / IMRAD] (Unpublished) |
| spellingShingle | Q Science (General) QD Chemistry Nur Hafizah, bt Ramli Synthesis, spectral studies and cytotoxicity of organotin(IV) complexes with hydrazone ligands |
| title | Synthesis, spectral studies and cytotoxicity of organotin(IV) complexes with hydrazone ligands |
| title_full | Synthesis, spectral studies and cytotoxicity of organotin(IV) complexes with hydrazone ligands |
| title_fullStr | Synthesis, spectral studies and cytotoxicity of organotin(IV) complexes with hydrazone ligands |
| title_full_unstemmed | Synthesis, spectral studies and cytotoxicity of organotin(IV) complexes with hydrazone ligands |
| title_short | Synthesis, spectral studies and cytotoxicity of organotin(IV) complexes with hydrazone ligands |
| title_sort | synthesis, spectral studies and cytotoxicity of organotin(iv) complexes with hydrazone ligands |
| topic | Q Science (General) QD Chemistry |
| url | http://ir.unimas.my/id/eprint/6272/ http://ir.unimas.my/id/eprint/6272/4/NUR%20HAFIZAH%20BT%20RAMLI%20ft.pdf |