Synthesis and biological activity of ampicillin derivatives
Ampicillin is a beta-lactam antibiotic that has been widely used clinically to treat bacterial infections particularly pathogens such as Escherichia coli. This research focused on the synthesis of ampicillin derivatives by covalently linking its amine bond through condensation reaction to isomers...
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| Format: | Final Year Project Report / IMRAD |
| Language: | English English |
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Universiti Malaysia Sarawak, UNIMAS
2012
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| Online Access: | http://ir.unimas.my/id/eprint/6263/ http://ir.unimas.my/id/eprint/6263/1/Amanda.pdf http://ir.unimas.my/id/eprint/6263/4/Amanda%20Liak%20ft.pdf |
| _version_ | 1848835878072352768 |
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| author | Liak, Amanda Man Dee |
| author_facet | Liak, Amanda Man Dee |
| author_sort | Liak, Amanda Man Dee |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Ampicillin is a beta-lactam antibiotic that has been widely used clinically to treat bacterial infections particularly
pathogens such as Escherichia coli. This research focused on the synthesis of ampicillin derivatives by covalently
linking its amine bond through condensation reaction to isomers of hydroxybenzlaldehyde (2-hydroxybenzaldehyde,
3-hydroxybenzaldehyde, and 4-hydroxybenzaldehyde) as well as 2,4-dimethoxybenzaldehyde. Five ampicillin
derivatives compound have been synthesized. The synthesized compounds were characterized using FTIR, 1HNMR and 13CNMR. The antibacterial activity was evaluated according to its zone of inhibition and minimum
concentration value using turbidimetric method against the growth of Escherichia coli. However, the results
indicated that the synthesized compound did not exhibit any significant antibacterial activity against Escherichia
coli. The effects of the structure of the investigated compounds on the antibacterial activity were discussed. |
| first_indexed | 2025-11-15T06:14:52Z |
| format | Final Year Project Report / IMRAD |
| id | unimas-6263 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T06:14:52Z |
| publishDate | 2012 |
| publisher | Universiti Malaysia Sarawak, UNIMAS |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-62632024-03-06T08:27:12Z http://ir.unimas.my/id/eprint/6263/ Synthesis and biological activity of ampicillin derivatives Liak, Amanda Man Dee Q Science (General) QR Microbiology Ampicillin is a beta-lactam antibiotic that has been widely used clinically to treat bacterial infections particularly pathogens such as Escherichia coli. This research focused on the synthesis of ampicillin derivatives by covalently linking its amine bond through condensation reaction to isomers of hydroxybenzlaldehyde (2-hydroxybenzaldehyde, 3-hydroxybenzaldehyde, and 4-hydroxybenzaldehyde) as well as 2,4-dimethoxybenzaldehyde. Five ampicillin derivatives compound have been synthesized. The synthesized compounds were characterized using FTIR, 1HNMR and 13CNMR. The antibacterial activity was evaluated according to its zone of inhibition and minimum concentration value using turbidimetric method against the growth of Escherichia coli. However, the results indicated that the synthesized compound did not exhibit any significant antibacterial activity against Escherichia coli. The effects of the structure of the investigated compounds on the antibacterial activity were discussed. Universiti Malaysia Sarawak, UNIMAS 2012 Final Year Project Report / IMRAD NonPeerReviewed text en http://ir.unimas.my/id/eprint/6263/1/Amanda.pdf text en http://ir.unimas.my/id/eprint/6263/4/Amanda%20Liak%20ft.pdf Liak, Amanda Man Dee (2012) Synthesis and biological activity of ampicillin derivatives. [Final Year Project Report / IMRAD] (Unpublished) |
| spellingShingle | Q Science (General) QR Microbiology Liak, Amanda Man Dee Synthesis and biological activity of ampicillin derivatives |
| title | Synthesis and biological activity of ampicillin derivatives |
| title_full | Synthesis and biological activity of ampicillin derivatives |
| title_fullStr | Synthesis and biological activity of ampicillin derivatives |
| title_full_unstemmed | Synthesis and biological activity of ampicillin derivatives |
| title_short | Synthesis and biological activity of ampicillin derivatives |
| title_sort | synthesis and biological activity of ampicillin derivatives |
| topic | Q Science (General) QR Microbiology |
| url | http://ir.unimas.my/id/eprint/6263/ http://ir.unimas.my/id/eprint/6263/1/Amanda.pdf http://ir.unimas.my/id/eprint/6263/4/Amanda%20Liak%20ft.pdf |