Phytochemical studies and biological activity of goniothalamus macrophyllus
Phytochemical and biological studies have been carried out on the extract obtained from the leaves of Goniothalamus macrophyllus. Extraction using methanol gave dark green extract of 33.27 g (7.25%). Solvent partition was carried out using solvents with increasing polarity in the order of hexane, di...
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| Format: | Final Year Project Report / IMRAD |
| Language: | English |
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Universiti Malaysia Sarawak, UNIMAS
2012
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| Online Access: | http://ir.unimas.my/id/eprint/6233/ http://ir.unimas.my/id/eprint/6233/4/Nurfarahen%20binti%20Jamil%20ft.pdf |
| _version_ | 1848835869233905664 |
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| author | Nurfarahen, Binti Jamil |
| author_facet | Nurfarahen, Binti Jamil |
| author_sort | Nurfarahen, Binti Jamil |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Phytochemical and biological studies have been carried out on the extract obtained from the leaves of Goniothalamus macrophyllus. Extraction using methanol gave dark green extract of 33.27 g (7.25%). Solvent partition was carried out using solvents with increasing polarity in the order of hexane, dichloromethane and ethyl acetate. Isolation and purification were performed on dichloromethane and methanol partition using column chromatography. Two semipure compound namely Compound 1 and Compound 2 corresponding to molecular mass of 128 g/mol and 200 g/mol, respectively were isolated. Compound 1 was isolated as white crystal needle with melting point in the range of 115.0-117.0 C and Rf value of 0.52 in
dichloromethane:ethyl acetate (1:1). Infrared spectrum revealed strong absorption band at frequency 1689 cm-1
that was assigned to C=O. Based on the NMR spectrum, the compound have 11 protons and 10 carbons. Due to impurities, the information was not enough to elucidate the structure of Compound 1. Compound 2 was isolated as white solid with melting point in the range 84.5-86.0 C and Rf value of 0.82 in dichloromethane. Based on the 1H and 13C NMR spectrum, it indicates there were 12 protons and 13 carbons. Based on the spectral data on published data, Compound 2 has been identified as goniothalamin. The brine shrimp toxicity test showed that none of the extracts were toxic to Artemia salina. |
| first_indexed | 2025-11-15T06:14:43Z |
| format | Final Year Project Report / IMRAD |
| id | unimas-6233 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:14:43Z |
| publishDate | 2012 |
| publisher | Universiti Malaysia Sarawak, UNIMAS |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-62332023-11-16T08:44:46Z http://ir.unimas.my/id/eprint/6233/ Phytochemical studies and biological activity of goniothalamus macrophyllus Nurfarahen, Binti Jamil Q Science (General) QH301 Biology SB Plant culture Phytochemical and biological studies have been carried out on the extract obtained from the leaves of Goniothalamus macrophyllus. Extraction using methanol gave dark green extract of 33.27 g (7.25%). Solvent partition was carried out using solvents with increasing polarity in the order of hexane, dichloromethane and ethyl acetate. Isolation and purification were performed on dichloromethane and methanol partition using column chromatography. Two semipure compound namely Compound 1 and Compound 2 corresponding to molecular mass of 128 g/mol and 200 g/mol, respectively were isolated. Compound 1 was isolated as white crystal needle with melting point in the range of 115.0-117.0 C and Rf value of 0.52 in dichloromethane:ethyl acetate (1:1). Infrared spectrum revealed strong absorption band at frequency 1689 cm-1 that was assigned to C=O. Based on the NMR spectrum, the compound have 11 protons and 10 carbons. Due to impurities, the information was not enough to elucidate the structure of Compound 1. Compound 2 was isolated as white solid with melting point in the range 84.5-86.0 C and Rf value of 0.82 in dichloromethane. Based on the 1H and 13C NMR spectrum, it indicates there were 12 protons and 13 carbons. Based on the spectral data on published data, Compound 2 has been identified as goniothalamin. The brine shrimp toxicity test showed that none of the extracts were toxic to Artemia salina. Universiti Malaysia Sarawak, UNIMAS 2012 Final Year Project Report / IMRAD NonPeerReviewed text en http://ir.unimas.my/id/eprint/6233/4/Nurfarahen%20binti%20Jamil%20ft.pdf Nurfarahen, Binti Jamil (2012) Phytochemical studies and biological activity of goniothalamus macrophyllus. [Final Year Project Report / IMRAD] (Unpublished) |
| spellingShingle | Q Science (General) QH301 Biology SB Plant culture Nurfarahen, Binti Jamil Phytochemical studies and biological activity of goniothalamus macrophyllus |
| title | Phytochemical studies and biological activity of goniothalamus macrophyllus |
| title_full | Phytochemical studies and biological activity of goniothalamus macrophyllus |
| title_fullStr | Phytochemical studies and biological activity of goniothalamus macrophyllus |
| title_full_unstemmed | Phytochemical studies and biological activity of goniothalamus macrophyllus |
| title_short | Phytochemical studies and biological activity of goniothalamus macrophyllus |
| title_sort | phytochemical studies and biological activity of goniothalamus macrophyllus |
| topic | Q Science (General) QH301 Biology SB Plant culture |
| url | http://ir.unimas.my/id/eprint/6233/ http://ir.unimas.my/id/eprint/6233/4/Nurfarahen%20binti%20Jamil%20ft.pdf |