Chromosome fragility in nasopharyngeal carcinoma (NPC)
Nasopharyngeal carcinoma (NPC) is reported to be associated with Epstein-Barr virus (EBV) infection as well as genetic alterations in the nasopharyngeal epithelium. These include common deletions at 3p, 9p, 11q, 13q and 14q; and additions at 1q, 3q, 8q, 11q and 12p. The 11q23 which contains the Mixe...
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| Format: | Thesis |
| Language: | English |
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Universiti Malaysia Sarawak, (UNIMAS)
2007
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| Online Access: | http://ir.unimas.my/id/eprint/603/ http://ir.unimas.my/id/eprint/603/2/Peter%20Han%20Chung.pdf |
| _version_ | 1848834578603573248 |
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| author | Yee, Peter Han Chung |
| author_facet | Yee, Peter Han Chung |
| author_sort | Yee, Peter Han Chung |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Nasopharyngeal carcinoma (NPC) is reported to be associated with Epstein-Barr virus (EBV) infection as well as genetic alterations in the nasopharyngeal epithelium. These include common deletions at 3p, 9p, 11q, 13q and 14q; and additions at 1q, 3q, 8q, 11q and 12p. The 11q23 which contains the Mixed Lineage Leukaemia (MLL) gene appears to be the common region of deletion. Till date, the mechanism of chromosome rearrangements (addition or deletion) is unknown. However, apoptosis induced chromosome break within the MLL gne have been reported in the leukaemia cells. Thus, the aim of this project is to elucidate the role of apoptosis /EBV-induced apoptosis which may lead to chromosomal rearrangement in NPC. Materials and Methods: NPC cell line was treated with apoptotic stimuli and purified DNA fragments were separated on agarose gel. |
| first_indexed | 2025-11-15T05:54:12Z |
| format | Thesis |
| id | unimas-603 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T05:54:12Z |
| publishDate | 2007 |
| publisher | Universiti Malaysia Sarawak, (UNIMAS) |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-6032023-06-12T07:04:58Z http://ir.unimas.my/id/eprint/603/ Chromosome fragility in nasopharyngeal carcinoma (NPC) Yee, Peter Han Chung RC0254 Neoplasms. Tumors. Oncology (including Cancer) Nasopharyngeal carcinoma (NPC) is reported to be associated with Epstein-Barr virus (EBV) infection as well as genetic alterations in the nasopharyngeal epithelium. These include common deletions at 3p, 9p, 11q, 13q and 14q; and additions at 1q, 3q, 8q, 11q and 12p. The 11q23 which contains the Mixed Lineage Leukaemia (MLL) gene appears to be the common region of deletion. Till date, the mechanism of chromosome rearrangements (addition or deletion) is unknown. However, apoptosis induced chromosome break within the MLL gne have been reported in the leukaemia cells. Thus, the aim of this project is to elucidate the role of apoptosis /EBV-induced apoptosis which may lead to chromosomal rearrangement in NPC. Materials and Methods: NPC cell line was treated with apoptotic stimuli and purified DNA fragments were separated on agarose gel. Universiti Malaysia Sarawak, (UNIMAS) 2007 Thesis NonPeerReviewed text en http://ir.unimas.my/id/eprint/603/2/Peter%20Han%20Chung.pdf Yee, Peter Han Chung (2007) Chromosome fragility in nasopharyngeal carcinoma (NPC). Masters thesis, Universiti Malaysia Sarawak (UNIMAS). |
| spellingShingle | RC0254 Neoplasms. Tumors. Oncology (including Cancer) Yee, Peter Han Chung Chromosome fragility in nasopharyngeal carcinoma (NPC) |
| title | Chromosome fragility in nasopharyngeal carcinoma (NPC) |
| title_full | Chromosome fragility in nasopharyngeal carcinoma (NPC) |
| title_fullStr | Chromosome fragility in nasopharyngeal carcinoma (NPC) |
| title_full_unstemmed | Chromosome fragility in nasopharyngeal carcinoma (NPC) |
| title_short | Chromosome fragility in nasopharyngeal carcinoma (NPC) |
| title_sort | chromosome fragility in nasopharyngeal carcinoma (npc) |
| topic | RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| url | http://ir.unimas.my/id/eprint/603/ http://ir.unimas.my/id/eprint/603/2/Peter%20Han%20Chung.pdf |