Topoisomerase I inhibition and cytotoxicity of 5-Bromo- and 5-Phenylterbenzimidazoles

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Topoisomerase I inhibition and cytotoxicity of 5-Bromo- and 5-Phenylterbenzimidazoles

Topoisomerase I is an enzyme that is essential for maintaining the three-dimensional structure of DNA during the processes of transcription, translation and mitosis. With the introduction of new clinical agents that are effective in poisoning topoisomerase I, this enzyme has proved to be an attracti...

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Bibliographic Details
Main Authors:	Rangarajan, M., Kim, J.S., Sim, S.P, Liu, A., Liu, L.F., LaVoie, E.J.
Format:	Article
Language:	English
Published:	Bioorganic & Medicinal Chemistry Letters 2000
Subjects:	QD Chemistry R Medicine (General)
Online Access:	http://ir.unimas.my/id/eprint/2497/ http://ir.unimas.my/id/eprint/2497/1/Topoisomerase%20I%20inhibition%20and%20cytotoxicity%20of%205-Bromo-%20and%205-Phenylterbenzimidazoles.pdf

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