An Immunohistochemical Study of CD1a and CD83-Positive Infiltrating Dendritic Cell Density in Cervical Neoplasia
Cervical carcinoma is the second leading cancer in women in Malaysia, after breast cancer. Human papillomavirus (HPV) has been implicated in the development of dysplasia or cervical intraepithelial neoplasia and progression to squamous cell carcinoma. Because of the confinement of the human papillom...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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International Society of Gynecological Pathologists
2007
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| Online Access: | http://ir.unimas.my/id/eprint/2212/ http://ir.unimas.my/id/eprint/2212/1/Hayati.pdf |
| _version_ | 1848834932578713600 |
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| author | Mohammad Zulkarnaen, Ahmad Narihan Hayati, Abdul Rahman |
| author_facet | Mohammad Zulkarnaen, Ahmad Narihan Hayati, Abdul Rahman |
| author_sort | Mohammad Zulkarnaen, Ahmad Narihan |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Cervical carcinoma is the second leading cancer in women in Malaysia, after breast cancer. Human papillomavirus (HPV) has been implicated in the development of dysplasia or cervical intraepithelial neoplasia and progression to squamous cell carcinoma. Because of the confinement of the human papillomavirus infection within the epithelial layer, the presence of dentritic cells or Langerhans cells in epithelial layer of the ectocervix is paramount in producing immune response. The mature dentritic cells express CD83 and high CD40/80/86, whereas the immature cells express CD1a and low CD40/80/86. By identifying CD1a and CD83, theoretically, both immature and mature dentritic cell populations can be studied. In view of the facts, we investigated the infiltrating cell density of mature and immature dentritic cells in cervical neoplasia. |
| first_indexed | 2025-11-15T05:59:50Z |
| format | Article |
| id | unimas-2212 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T05:59:50Z |
| publishDate | 2007 |
| publisher | International Society of Gynecological Pathologists |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-22122022-01-19T07:41:50Z http://ir.unimas.my/id/eprint/2212/ An Immunohistochemical Study of CD1a and CD83-Positive Infiltrating Dendritic Cell Density in Cervical Neoplasia Mohammad Zulkarnaen, Ahmad Narihan Hayati, Abdul Rahman RB Pathology Cervical carcinoma is the second leading cancer in women in Malaysia, after breast cancer. Human papillomavirus (HPV) has been implicated in the development of dysplasia or cervical intraepithelial neoplasia and progression to squamous cell carcinoma. Because of the confinement of the human papillomavirus infection within the epithelial layer, the presence of dentritic cells or Langerhans cells in epithelial layer of the ectocervix is paramount in producing immune response. The mature dentritic cells express CD83 and high CD40/80/86, whereas the immature cells express CD1a and low CD40/80/86. By identifying CD1a and CD83, theoretically, both immature and mature dentritic cell populations can be studied. In view of the facts, we investigated the infiltrating cell density of mature and immature dentritic cells in cervical neoplasia. International Society of Gynecological Pathologists 2007 Article NonPeerReviewed text en http://ir.unimas.my/id/eprint/2212/1/Hayati.pdf Mohammad Zulkarnaen, Ahmad Narihan and Hayati, Abdul Rahman (2007) An Immunohistochemical Study of CD1a and CD83-Positive Infiltrating Dendritic Cell Density in Cervical Neoplasia. International Journal of Gynecological Pathology, 26 (1). pp. 83-88. |
| spellingShingle | RB Pathology Mohammad Zulkarnaen, Ahmad Narihan Hayati, Abdul Rahman An Immunohistochemical Study of CD1a and CD83-Positive Infiltrating Dendritic Cell Density in Cervical Neoplasia |
| title | An Immunohistochemical Study of CD1a and CD83-Positive Infiltrating Dendritic Cell Density in Cervical Neoplasia |
| title_full | An Immunohistochemical Study of CD1a and CD83-Positive Infiltrating Dendritic Cell Density in Cervical Neoplasia |
| title_fullStr | An Immunohistochemical Study of CD1a and CD83-Positive Infiltrating Dendritic Cell Density in Cervical Neoplasia |
| title_full_unstemmed | An Immunohistochemical Study of CD1a and CD83-Positive Infiltrating Dendritic Cell Density in Cervical Neoplasia |
| title_short | An Immunohistochemical Study of CD1a and CD83-Positive Infiltrating Dendritic Cell Density in Cervical Neoplasia |
| title_sort | immunohistochemical study of cd1a and cd83-positive infiltrating dendritic cell density in cervical neoplasia |
| topic | RB Pathology |
| url | http://ir.unimas.my/id/eprint/2212/ http://ir.unimas.my/id/eprint/2212/1/Hayati.pdf |