8,9-Methylenedioxybenzo[i]phenanthridines_ Topoisomerase I-Targeting activity and cytotoxicity
Substituted benzo[i]phenanthridines that have incorporated within their structure an 8,9-methylenedioxy group can exhibit topoisomerase I-targeting activity. Structure–activity studies were performed to examine the influence of saturation at the 11,12-positions of several substituted 8,9-methylenedi...
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| Format: | Article |
| Language: | English |
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Elsevier Ltd
2003
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| Online Access: | http://ir.unimas.my/id/eprint/2199/ http://ir.unimas.my/id/eprint/2199/1/Bioorganic.pdf |
| _version_ | 1848834929330225152 |
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| author | Li, D. Zhao, B. Sim, S.P Li, T.K Liu, A. Liu, L.F. LaVoie, E.J. |
| author_facet | Li, D. Zhao, B. Sim, S.P Li, T.K Liu, A. Liu, L.F. LaVoie, E.J. |
| author_sort | Li, D. |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Substituted benzo[i]phenanthridines that have incorporated within their structure an 8,9-methylenedioxy group can exhibit topoisomerase I-targeting activity. Structure–activity studies were performed to examine the influence of saturation at the 11,12-positions of several substituted 8,9-methylenedioxybenzo[i]phenanthridines. The activities of these dihydro analogues were compared to those of their unsaturated analogues. In addition, the influence of varying substituents at the 2- and 3-positions within the A-ring of these 8,9-methylenedioxybenzo[i]phenanthridines on their relative potency as topoisomerase I-targeting agents and cell proliferation as determined using the MTT assay was investigated. 2,3-Dimethoxy-8,9 Methylenedioxybenzo[i]phenanthridine and its 11,12-dihydro derivative were among the more potent analogues evaluated with regard to topoisomerase I-targeting activity and cytotoxicity. |
| first_indexed | 2025-11-15T05:59:47Z |
| format | Article |
| id | unimas-2199 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T05:59:47Z |
| publishDate | 2003 |
| publisher | Elsevier Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-21992022-01-19T02:27:31Z http://ir.unimas.my/id/eprint/2199/ 8,9-Methylenedioxybenzo[i]phenanthridines_ Topoisomerase I-Targeting activity and cytotoxicity Li, D. Zhao, B. Sim, S.P Li, T.K Liu, A. Liu, L.F. LaVoie, E.J. QD Chemistry R Medicine (General) Substituted benzo[i]phenanthridines that have incorporated within their structure an 8,9-methylenedioxy group can exhibit topoisomerase I-targeting activity. Structure–activity studies were performed to examine the influence of saturation at the 11,12-positions of several substituted 8,9-methylenedioxybenzo[i]phenanthridines. The activities of these dihydro analogues were compared to those of their unsaturated analogues. In addition, the influence of varying substituents at the 2- and 3-positions within the A-ring of these 8,9-methylenedioxybenzo[i]phenanthridines on their relative potency as topoisomerase I-targeting agents and cell proliferation as determined using the MTT assay was investigated. 2,3-Dimethoxy-8,9 Methylenedioxybenzo[i]phenanthridine and its 11,12-dihydro derivative were among the more potent analogues evaluated with regard to topoisomerase I-targeting activity and cytotoxicity. Elsevier Ltd 2003 Article NonPeerReviewed text en http://ir.unimas.my/id/eprint/2199/1/Bioorganic.pdf Li, D. and Zhao, B. and Sim, S.P and Li, T.K and Liu, A. and Liu, L.F. and LaVoie, E.J. (2003) 8,9-Methylenedioxybenzo[i]phenanthridines_ Topoisomerase I-Targeting activity and cytotoxicity. Bioorganic & Medicinal Chemistry, 11 (17). pp. 3795-3805. http://www.sciencedirect.com/science/article/pii/S0968089603003948 |
| spellingShingle | QD Chemistry R Medicine (General) Li, D. Zhao, B. Sim, S.P Li, T.K Liu, A. Liu, L.F. LaVoie, E.J. 8,9-Methylenedioxybenzo[i]phenanthridines_ Topoisomerase I-Targeting activity and cytotoxicity |
| title | 8,9-Methylenedioxybenzo[i]phenanthridines_ Topoisomerase I-Targeting activity and cytotoxicity |
| title_full | 8,9-Methylenedioxybenzo[i]phenanthridines_ Topoisomerase I-Targeting activity and cytotoxicity |
| title_fullStr | 8,9-Methylenedioxybenzo[i]phenanthridines_ Topoisomerase I-Targeting activity and cytotoxicity |
| title_full_unstemmed | 8,9-Methylenedioxybenzo[i]phenanthridines_ Topoisomerase I-Targeting activity and cytotoxicity |
| title_short | 8,9-Methylenedioxybenzo[i]phenanthridines_ Topoisomerase I-Targeting activity and cytotoxicity |
| title_sort | 8,9-methylenedioxybenzo[i]phenanthridines_ topoisomerase i-targeting activity and cytotoxicity |
| topic | QD Chemistry R Medicine (General) |
| url | http://ir.unimas.my/id/eprint/2199/ http://ir.unimas.my/id/eprint/2199/ http://ir.unimas.my/id/eprint/2199/1/Bioorganic.pdf |