Synthesis, modification, characterization and biological activity of 3-hydroxybenzaldehydesalicylhydrazide [Sintesis, modifikasi, pencirian dan aktiviti biologi 3-hidroksibenzaldehidesalisilhidrazida]
A series of hydrazone Schiff base (compounds S, S8, S10 and S12) were synthesized by condensation reaction of salicylhydrazide with 3-hydroxybenzaldehyde, 3-(octyloxy)benzaldehyde, 3-(decyloxy)benzaldehyde and 3-(dodecyloxy) benzaldehyde, respectively. Herein, the addition of alkane numbers are repo...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Malaysian Society of Analytical Sciences
2017
|
| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/18936/ http://ir.unimas.my/id/eprint/18936/7/SYNTHESIS.pdf |
| _version_ | 1848838613351006208 |
|---|---|
| author | Nornadia, Jasin Meng, Guan Tay Hashimatul Fatma, Hashim |
| author_facet | Nornadia, Jasin Meng, Guan Tay Hashimatul Fatma, Hashim |
| author_sort | Nornadia, Jasin |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | A series of hydrazone Schiff base (compounds S, S8, S10 and S12) were synthesized by condensation reaction of salicylhydrazide with 3-hydroxybenzaldehyde, 3-(octyloxy)benzaldehyde, 3-(decyloxy)benzaldehyde and 3-(dodecyloxy) benzaldehyde, respectively. Herein, the addition of alkane numbers are reported using suscessful Williamson etherification method by reacting 3-hydroxybenzaldehyde with bromooctane, bromodecane and bromododecane, respectively. All compounds were characterised using Fourier Transform Infrared and 1H Nuclear Mangnetic Resonance spectroscopic. The compounds were assayed to antibacterial activity against Gram-positive and Gram-negative bacteria using Bacillus cereus and Escherichia coli by disc diffusion method. Interestingly, among the compounds tested S8 showed a strong inhibition against Escherichia coli and none of the compounds tested show significant result against Bacillus cereus. |
| first_indexed | 2025-11-15T06:58:20Z |
| format | Article |
| id | unimas-18936 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:58:20Z |
| publishDate | 2017 |
| publisher | Malaysian Society of Analytical Sciences |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-189362022-06-22T03:24:16Z http://ir.unimas.my/id/eprint/18936/ Synthesis, modification, characterization and biological activity of 3-hydroxybenzaldehydesalicylhydrazide [Sintesis, modifikasi, pencirian dan aktiviti biologi 3-hidroksibenzaldehidesalisilhidrazida] Nornadia, Jasin Meng, Guan Tay Hashimatul Fatma, Hashim QD Chemistry A series of hydrazone Schiff base (compounds S, S8, S10 and S12) were synthesized by condensation reaction of salicylhydrazide with 3-hydroxybenzaldehyde, 3-(octyloxy)benzaldehyde, 3-(decyloxy)benzaldehyde and 3-(dodecyloxy) benzaldehyde, respectively. Herein, the addition of alkane numbers are reported using suscessful Williamson etherification method by reacting 3-hydroxybenzaldehyde with bromooctane, bromodecane and bromododecane, respectively. All compounds were characterised using Fourier Transform Infrared and 1H Nuclear Mangnetic Resonance spectroscopic. The compounds were assayed to antibacterial activity against Gram-positive and Gram-negative bacteria using Bacillus cereus and Escherichia coli by disc diffusion method. Interestingly, among the compounds tested S8 showed a strong inhibition against Escherichia coli and none of the compounds tested show significant result against Bacillus cereus. Malaysian Society of Analytical Sciences 2017-10 Article PeerReviewed text en http://ir.unimas.my/id/eprint/18936/7/SYNTHESIS.pdf Nornadia, Jasin and Meng, Guan Tay and Hashimatul Fatma, Hashim (2017) Synthesis, modification, characterization and biological activity of 3-hydroxybenzaldehydesalicylhydrazide [Sintesis, modifikasi, pencirian dan aktiviti biologi 3-hidroksibenzaldehidesalisilhidrazida]. Malaysian Journal of Analytical Sciences, 21 (5). pp. 1195-1202. ISSN 1394-2506 http://www.ukm.my/mjas/mjas2018/ https://www.scopus.com/inward/record.uri?eid=2-s2.0-85032027821&doi=10.17576%2fmjas-2017-2105-24&partnerID=40&md5=e7bdfc217e5a78ba945222607aca97df |
| spellingShingle | QD Chemistry Nornadia, Jasin Meng, Guan Tay Hashimatul Fatma, Hashim Synthesis, modification, characterization and biological activity of 3-hydroxybenzaldehydesalicylhydrazide [Sintesis, modifikasi, pencirian dan aktiviti biologi 3-hidroksibenzaldehidesalisilhidrazida] |
| title | Synthesis, modification, characterization and biological activity of 3-hydroxybenzaldehydesalicylhydrazide [Sintesis, modifikasi, pencirian dan aktiviti biologi 3-hidroksibenzaldehidesalisilhidrazida] |
| title_full | Synthesis, modification, characterization and biological activity of 3-hydroxybenzaldehydesalicylhydrazide [Sintesis, modifikasi, pencirian dan aktiviti biologi 3-hidroksibenzaldehidesalisilhidrazida] |
| title_fullStr | Synthesis, modification, characterization and biological activity of 3-hydroxybenzaldehydesalicylhydrazide [Sintesis, modifikasi, pencirian dan aktiviti biologi 3-hidroksibenzaldehidesalisilhidrazida] |
| title_full_unstemmed | Synthesis, modification, characterization and biological activity of 3-hydroxybenzaldehydesalicylhydrazide [Sintesis, modifikasi, pencirian dan aktiviti biologi 3-hidroksibenzaldehidesalisilhidrazida] |
| title_short | Synthesis, modification, characterization and biological activity of 3-hydroxybenzaldehydesalicylhydrazide [Sintesis, modifikasi, pencirian dan aktiviti biologi 3-hidroksibenzaldehidesalisilhidrazida] |
| title_sort | synthesis, modification, characterization and biological activity of 3-hydroxybenzaldehydesalicylhydrazide [sintesis, modifikasi, pencirian dan aktiviti biologi 3-hidroksibenzaldehidesalisilhidrazida] |
| topic | QD Chemistry |
| url | http://ir.unimas.my/id/eprint/18936/ http://ir.unimas.my/id/eprint/18936/ http://ir.unimas.my/id/eprint/18936/ http://ir.unimas.my/id/eprint/18936/7/SYNTHESIS.pdf |