Synthesis and antibacterial activity of azo and aspirin-azo derivatives [Sintesis dan aktiviti antibakteria terhadap azo dan terbitan azo-aspirin]
A series of azo derivatives (1a-e) were synthesized via coupling reaction with of overall yield 58 - 72% while aspirin-azo derivatives (2a-e) were prepared by esterification reaction of aspirin and azo derivatives (1a-e) with overall yield 38 - 75%. In this study, the structures of synthesized compo...
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| Format: | Article |
| Language: | English |
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Malaysian Society of Analytical Sciences
2017
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| Online Access: | http://ir.unimas.my/id/eprint/18935/ http://ir.unimas.my/id/eprint/18935/7/zainab.pdf |
| _version_ | 1848838613007073280 |
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| author | Zainab, Ngaini Ho, Boon Kui |
| author_facet | Zainab, Ngaini Ho, Boon Kui |
| author_sort | Zainab, Ngaini |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | A series of azo derivatives (1a-e) were synthesized via coupling reaction with of overall yield 58 - 72% while aspirin-azo derivatives (2a-e) were prepared by esterification reaction of aspirin and azo derivatives (1a-e) with overall yield 38 - 75%. In this study, the structures of synthesized compounds were characterized using elemental analysis (CHN), nuclear magnetic resonance (1H NMR and 13C NMR) and Fourier Transform Infrared (FTIR) spectroscopy. The synthesized compounds were tested on antibacterial activity against Escherichia coli ATCC 25922 and Staphylococcus aureus S48/81 via turbidimetric kinetic method. The azo derivative-substituted fluorine, 1d showed the highest antibacterial activities against Escherichia coli ATCC 25922 and Staphylococcus aureus S48/81 compared with other synthesized compounds. However, synthesized aspirin-azo derivatives (2a-e) showed weak antibacterial activity against tested bacteria due to bulky molecular structure thus hindered the penetration into bacterial cell wall. © 2017, Malaysian Society of Analytical Sciences. |
| first_indexed | 2025-11-15T06:58:20Z |
| format | Article |
| id | unimas-18935 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:58:20Z |
| publishDate | 2017 |
| publisher | Malaysian Society of Analytical Sciences |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-189352021-05-21T11:29:31Z http://ir.unimas.my/id/eprint/18935/ Synthesis and antibacterial activity of azo and aspirin-azo derivatives [Sintesis dan aktiviti antibakteria terhadap azo dan terbitan azo-aspirin] Zainab, Ngaini Ho, Boon Kui QD Chemistry A series of azo derivatives (1a-e) were synthesized via coupling reaction with of overall yield 58 - 72% while aspirin-azo derivatives (2a-e) were prepared by esterification reaction of aspirin and azo derivatives (1a-e) with overall yield 38 - 75%. In this study, the structures of synthesized compounds were characterized using elemental analysis (CHN), nuclear magnetic resonance (1H NMR and 13C NMR) and Fourier Transform Infrared (FTIR) spectroscopy. The synthesized compounds were tested on antibacterial activity against Escherichia coli ATCC 25922 and Staphylococcus aureus S48/81 via turbidimetric kinetic method. The azo derivative-substituted fluorine, 1d showed the highest antibacterial activities against Escherichia coli ATCC 25922 and Staphylococcus aureus S48/81 compared with other synthesized compounds. However, synthesized aspirin-azo derivatives (2a-e) showed weak antibacterial activity against tested bacteria due to bulky molecular structure thus hindered the penetration into bacterial cell wall. © 2017, Malaysian Society of Analytical Sciences. Malaysian Society of Analytical Sciences 2017-10 Article PeerReviewed text en http://ir.unimas.my/id/eprint/18935/7/zainab.pdf Zainab, Ngaini and Ho, Boon Kui (2017) Synthesis and antibacterial activity of azo and aspirin-azo derivatives [Sintesis dan aktiviti antibakteria terhadap azo dan terbitan azo-aspirin]. Malaysian Journal of Analytical Sciences, 21 (5). pp. 1183-1194. ISSN 13942506 http://www.ukm.my/mjas/mjas2018/ DOI: 10.17576/mjas-2017-2105-23 |
| spellingShingle | QD Chemistry Zainab, Ngaini Ho, Boon Kui Synthesis and antibacterial activity of azo and aspirin-azo derivatives [Sintesis dan aktiviti antibakteria terhadap azo dan terbitan azo-aspirin] |
| title | Synthesis and antibacterial activity of azo and aspirin-azo derivatives [Sintesis dan aktiviti antibakteria terhadap azo dan terbitan azo-aspirin] |
| title_full | Synthesis and antibacterial activity of azo and aspirin-azo derivatives [Sintesis dan aktiviti antibakteria terhadap azo dan terbitan azo-aspirin] |
| title_fullStr | Synthesis and antibacterial activity of azo and aspirin-azo derivatives [Sintesis dan aktiviti antibakteria terhadap azo dan terbitan azo-aspirin] |
| title_full_unstemmed | Synthesis and antibacterial activity of azo and aspirin-azo derivatives [Sintesis dan aktiviti antibakteria terhadap azo dan terbitan azo-aspirin] |
| title_short | Synthesis and antibacterial activity of azo and aspirin-azo derivatives [Sintesis dan aktiviti antibakteria terhadap azo dan terbitan azo-aspirin] |
| title_sort | synthesis and antibacterial activity of azo and aspirin-azo derivatives [sintesis dan aktiviti antibakteria terhadap azo dan terbitan azo-aspirin] |
| topic | QD Chemistry |
| url | http://ir.unimas.my/id/eprint/18935/ http://ir.unimas.my/id/eprint/18935/ http://ir.unimas.my/id/eprint/18935/ http://ir.unimas.my/id/eprint/18935/7/zainab.pdf |