Synthesis, characterization and antibacterial activities of hydrazone schiff base compounds and its derivatives [Sintesis, pencirian dan aktiviti antibakteria sebatian bes schiff hidrazon dan terbitannya
Biological activities (e.g. antibacterial) of hydrazone compound have received much attention from the synthetic chemists since last two decades. Herein, we would like to report the synthesis pathways as well as the spectroscopic characterization of three etherified hydrazone Schiff base compound, w...
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| Format: | Article |
| Language: | English |
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Malaysian Society of Analytical Sciences
2017
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| Online Access: | http://ir.unimas.my/id/eprint/18934/ http://ir.unimas.my/id/eprint/18934/7/SYNTHESIS.pdf |
| _version_ | 1848838612743880704 |
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| author | Ruwaida Asyikin, Abu Talip Meng, Guan Tay Hashimatul Fatma, Hashim |
| author_facet | Ruwaida Asyikin, Abu Talip Meng, Guan Tay Hashimatul Fatma, Hashim |
| author_sort | Ruwaida Asyikin, Abu Talip |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Biological activities (e.g. antibacterial) of hydrazone compound have received much attention from the synthetic chemists since last two decades. Herein, we would like to report the synthesis pathways as well as the spectroscopic characterization of three etherified hydrazone Schiff base compound, which were initiated from 2-hydroxyacetophenone. Hydrazone Schiff base compound was obtained through condensation reaction between 2-hydroxyacetophenone with benzhydrazide. Meanwhile the etherified derivatives of hydrazone Schiff base were prepared via Williamson ether synthesis under reflux condition. All the synthesized compounds were characterized using Fourier transformation infrared, UV-Vis and 1H nuclear magnetic resonance spectroscopy. In addition, the antibacterial activities of these compounds were also conducted using disc diffusion method against Bacillus cereus and Escherichia coli. |
| first_indexed | 2025-11-15T06:58:20Z |
| format | Article |
| id | unimas-18934 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:58:20Z |
| publishDate | 2017 |
| publisher | Malaysian Society of Analytical Sciences |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-189342022-06-23T02:35:05Z http://ir.unimas.my/id/eprint/18934/ Synthesis, characterization and antibacterial activities of hydrazone schiff base compounds and its derivatives [Sintesis, pencirian dan aktiviti antibakteria sebatian bes schiff hidrazon dan terbitannya Ruwaida Asyikin, Abu Talip Meng, Guan Tay Hashimatul Fatma, Hashim QD Chemistry Biological activities (e.g. antibacterial) of hydrazone compound have received much attention from the synthetic chemists since last two decades. Herein, we would like to report the synthesis pathways as well as the spectroscopic characterization of three etherified hydrazone Schiff base compound, which were initiated from 2-hydroxyacetophenone. Hydrazone Schiff base compound was obtained through condensation reaction between 2-hydroxyacetophenone with benzhydrazide. Meanwhile the etherified derivatives of hydrazone Schiff base were prepared via Williamson ether synthesis under reflux condition. All the synthesized compounds were characterized using Fourier transformation infrared, UV-Vis and 1H nuclear magnetic resonance spectroscopy. In addition, the antibacterial activities of these compounds were also conducted using disc diffusion method against Bacillus cereus and Escherichia coli. Malaysian Society of Analytical Sciences 2017-10 Article PeerReviewed text en http://ir.unimas.my/id/eprint/18934/7/SYNTHESIS.pdf Ruwaida Asyikin, Abu Talip and Meng, Guan Tay and Hashimatul Fatma, Hashim (2017) Synthesis, characterization and antibacterial activities of hydrazone schiff base compounds and its derivatives [Sintesis, pencirian dan aktiviti antibakteria sebatian bes schiff hidrazon dan terbitannya. Malaysian Journal of Analytical Sciences, 21 (5). pp. 1168-1175. ISSN 1394-2506 http://www.ukm.my/mjas/mjas2018/ DOI: 10.17576/mjas-2017-2105-21 |
| spellingShingle | QD Chemistry Ruwaida Asyikin, Abu Talip Meng, Guan Tay Hashimatul Fatma, Hashim Synthesis, characterization and antibacterial activities of hydrazone schiff base compounds and its derivatives [Sintesis, pencirian dan aktiviti antibakteria sebatian bes schiff hidrazon dan terbitannya |
| title | Synthesis, characterization and antibacterial activities of hydrazone schiff base compounds and its derivatives [Sintesis, pencirian dan aktiviti antibakteria sebatian bes schiff hidrazon dan terbitannya |
| title_full | Synthesis, characterization and antibacterial activities of hydrazone schiff base compounds and its derivatives [Sintesis, pencirian dan aktiviti antibakteria sebatian bes schiff hidrazon dan terbitannya |
| title_fullStr | Synthesis, characterization and antibacterial activities of hydrazone schiff base compounds and its derivatives [Sintesis, pencirian dan aktiviti antibakteria sebatian bes schiff hidrazon dan terbitannya |
| title_full_unstemmed | Synthesis, characterization and antibacterial activities of hydrazone schiff base compounds and its derivatives [Sintesis, pencirian dan aktiviti antibakteria sebatian bes schiff hidrazon dan terbitannya |
| title_short | Synthesis, characterization and antibacterial activities of hydrazone schiff base compounds and its derivatives [Sintesis, pencirian dan aktiviti antibakteria sebatian bes schiff hidrazon dan terbitannya |
| title_sort | synthesis, characterization and antibacterial activities of hydrazone schiff base compounds and its derivatives [sintesis, pencirian dan aktiviti antibakteria sebatian bes schiff hidrazon dan terbitannya |
| topic | QD Chemistry |
| url | http://ir.unimas.my/id/eprint/18934/ http://ir.unimas.my/id/eprint/18934/ http://ir.unimas.my/id/eprint/18934/ http://ir.unimas.my/id/eprint/18934/7/SYNTHESIS.pdf |