Synthesis and characterisation of halogenated bis(acylthiourea) derivatives and its antibacterial activities
A total of 12 bis(acylthiourea) derivatives with different pharmacophores have been synthesized via nucleophilic substitution reaction of benzene-1,4-dicarbonyl isothiocyanate intermediate with aromatic amine bearing halogens at the ortho, meta and para positions. The structures of the synthesised c...
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| Format: | Article |
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Taylor & Francis
2017
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| Online Access: | http://ir.unimas.my/id/eprint/18505/ |
| _version_ | 1848838528532742144 |
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| author | Ainaa Nadiah, Abd Halim Zainab, Ngaini |
| author_facet | Ainaa Nadiah, Abd Halim Zainab, Ngaini |
| author_sort | Ainaa Nadiah, Abd Halim |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | A total of 12 bis(acylthiourea) derivatives with different pharmacophores have been synthesized via nucleophilic substitution reaction of benzene-1,4-dicarbonyl isothiocyanate intermediate with aromatic amine bearing halogens at the ortho, meta and para positions. The structures of the synthesised compounds were confirmed by CHN elemental analysis, FT-IR, ¹H NMR and ¹³C NMR spectroscopies. Antibacterial studies of the compounds via the Kirby Bauer disc diffusion method against Escherichia coli (E.coli) ATCC 25922 and Staphylococcus aureus (S. aureus) S48/81 demonstrated that bis(acylthiourea) N¹,N⁴-bis[(2-chlorophenyl)carbamothioyl]terephthalamide (4) and N¹,N⁴-bis[(2-bromophenyl)carbamothioyl]terephthalamide (7) bearing Cl and Br at the ortho position exhibited excellent activities against both bacteria strains compared to ampicillin standard. |
| first_indexed | 2025-11-15T06:56:59Z |
| format | Article |
| id | unimas-18505 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| last_indexed | 2025-11-15T06:56:59Z |
| publishDate | 2017 |
| publisher | Taylor & Francis |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-185052017-11-09T07:36:16Z http://ir.unimas.my/id/eprint/18505/ Synthesis and characterisation of halogenated bis(acylthiourea) derivatives and its antibacterial activities Ainaa Nadiah, Abd Halim Zainab, Ngaini Q Science (General) A total of 12 bis(acylthiourea) derivatives with different pharmacophores have been synthesized via nucleophilic substitution reaction of benzene-1,4-dicarbonyl isothiocyanate intermediate with aromatic amine bearing halogens at the ortho, meta and para positions. The structures of the synthesised compounds were confirmed by CHN elemental analysis, FT-IR, ¹H NMR and ¹³C NMR spectroscopies. Antibacterial studies of the compounds via the Kirby Bauer disc diffusion method against Escherichia coli (E.coli) ATCC 25922 and Staphylococcus aureus (S. aureus) S48/81 demonstrated that bis(acylthiourea) N¹,N⁴-bis[(2-chlorophenyl)carbamothioyl]terephthalamide (4) and N¹,N⁴-bis[(2-bromophenyl)carbamothioyl]terephthalamide (7) bearing Cl and Br at the ortho position exhibited excellent activities against both bacteria strains compared to ampicillin standard. Taylor & Francis 2017 Article PeerReviewed Ainaa Nadiah, Abd Halim and Zainab, Ngaini (2017) Synthesis and characterisation of halogenated bis(acylthiourea) derivatives and its antibacterial activities. Phosphorus, Sulfur, and Silicon and the Related Elements, 192 (9). ISSN 10426507 https://www.researchgate.net/publication/316030203 DOI: 10.1080/10426507.2017.1315421 |
| spellingShingle | Q Science (General) Ainaa Nadiah, Abd Halim Zainab, Ngaini Synthesis and characterisation of halogenated bis(acylthiourea) derivatives and its antibacterial activities |
| title | Synthesis and characterisation of halogenated bis(acylthiourea) derivatives and its antibacterial activities |
| title_full | Synthesis and characterisation of halogenated bis(acylthiourea) derivatives and its antibacterial activities |
| title_fullStr | Synthesis and characterisation of halogenated bis(acylthiourea) derivatives and its antibacterial activities |
| title_full_unstemmed | Synthesis and characterisation of halogenated bis(acylthiourea) derivatives and its antibacterial activities |
| title_short | Synthesis and characterisation of halogenated bis(acylthiourea) derivatives and its antibacterial activities |
| title_sort | synthesis and characterisation of halogenated bis(acylthiourea) derivatives and its antibacterial activities |
| topic | Q Science (General) |
| url | http://ir.unimas.my/id/eprint/18505/ http://ir.unimas.my/id/eprint/18505/ http://ir.unimas.my/id/eprint/18505/ |