Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death
In the daily practice of forensic pathology, sudden cardiac death (SCD) is a diagnostic challenge. Our aim was to determine the usefulness of blood biomarkers [creatine kinase CK-MB, myoglobin, troponin I and T (cTn-T & T), and lactate dehydrogenase] measured by immunoassay technique, in the pos...
| Main Authors: | , , , , , |
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| Format: | Article |
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Blackwell Publishing Inc.
2017
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| Online Access: | http://ir.unimas.my/id/eprint/17878/ |
| _version_ | 1848838388477591552 |
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| author | Octavio, Carvajal-Zarrabal Patricia M., Hayward-Jones Cirilo Nolasco, Nolasco-Hipólito Dulce, Barradas-Dermitz Ana Laura, Calderón-Garcidueñas Noe, Lopez-Amador |
| author_facet | Octavio, Carvajal-Zarrabal Patricia M., Hayward-Jones Cirilo Nolasco, Nolasco-Hipólito Dulce, Barradas-Dermitz Ana Laura, Calderón-Garcidueñas Noe, Lopez-Amador |
| author_sort | Octavio, Carvajal-Zarrabal |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | In the daily practice of forensic pathology, sudden cardiac death (SCD) is a diagnostic challenge. Our aim was to determine the usefulness of blood biomarkers [creatine kinase CK-MB, myoglobin, troponin I and T (cTn-T & T), and lactate dehydrogenase] measured by immunoassay technique, in the postmortem diagnosis of SCD. Two groups were compared, 20 corpses with SCD and 8 controls. Statistical significance was determined by variance analysis procedures, with a post hoc Tukey multiple range test for comparison of means (P <0.05). SCD cases showed significantly higher levels (P <0.05) of cTn-T and cTn-I compared to the control group. Although only cases within the first 8 hours of postmortem interval were included, and the control group consisted mainly of violent death cases, our results suggest that blood troponin levels may be useful to support a diagnosis of SCD. |
| first_indexed | 2025-11-15T06:54:46Z |
| format | Article |
| id | unimas-17878 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| last_indexed | 2025-11-15T06:54:46Z |
| publishDate | 2017 |
| publisher | Blackwell Publishing Inc. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-178782017-10-02T07:05:32Z http://ir.unimas.my/id/eprint/17878/ Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death Octavio, Carvajal-Zarrabal Patricia M., Hayward-Jones Cirilo Nolasco, Nolasco-Hipólito Dulce, Barradas-Dermitz Ana Laura, Calderón-Garcidueñas Noe, Lopez-Amador TP Chemical technology In the daily practice of forensic pathology, sudden cardiac death (SCD) is a diagnostic challenge. Our aim was to determine the usefulness of blood biomarkers [creatine kinase CK-MB, myoglobin, troponin I and T (cTn-T & T), and lactate dehydrogenase] measured by immunoassay technique, in the postmortem diagnosis of SCD. Two groups were compared, 20 corpses with SCD and 8 controls. Statistical significance was determined by variance analysis procedures, with a post hoc Tukey multiple range test for comparison of means (P <0.05). SCD cases showed significantly higher levels (P <0.05) of cTn-T and cTn-I compared to the control group. Although only cases within the first 8 hours of postmortem interval were included, and the control group consisted mainly of violent death cases, our results suggest that blood troponin levels may be useful to support a diagnosis of SCD. Blackwell Publishing Inc. 2017 Article PeerReviewed Octavio, Carvajal-Zarrabal and Patricia M., Hayward-Jones and Cirilo Nolasco, Nolasco-Hipólito and Dulce, Barradas-Dermitz and Ana Laura, Calderón-Garcidueñas and Noe, Lopez-Amador (2017) Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death. Journal of Forensic Sciences, 62 (5). pp. 1332-1335. ISSN 0022-1198 http://onlinelibrary.wiley.com/doi/10.1111/1556-4029.13397/full DOI: 10.1111/1556-4029.13397 |
| spellingShingle | TP Chemical technology Octavio, Carvajal-Zarrabal Patricia M., Hayward-Jones Cirilo Nolasco, Nolasco-Hipólito Dulce, Barradas-Dermitz Ana Laura, Calderón-Garcidueñas Noe, Lopez-Amador Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death |
| title | Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death |
| title_full | Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death |
| title_fullStr | Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death |
| title_full_unstemmed | Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death |
| title_short | Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death |
| title_sort | use of cardiac injury markers in the postmortem diagnosis of sudden cardiac death |
| topic | TP Chemical technology |
| url | http://ir.unimas.my/id/eprint/17878/ http://ir.unimas.my/id/eprint/17878/ http://ir.unimas.my/id/eprint/17878/ |