Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death

In the daily practice of forensic pathology, sudden cardiac death (SCD) is a diagnostic challenge. Our aim was to determine the usefulness of blood biomarkers [creatine kinase CK-MB, myoglobin, troponin I and T (cTn-T & T), and lactate dehydrogenase] measured by immunoassay technique, in the pos...

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Bibliographic Details
Main Authors: Octavio, Carvajal-Zarrabal, Patricia M., Hayward-Jones, Cirilo Nolasco, Nolasco-Hipólito, Dulce, Barradas-Dermitz, Ana Laura, Calderón-Garcidueñas, Noe, Lopez-Amador
Format: Article
Published: Blackwell Publishing Inc. 2017
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Online Access:http://ir.unimas.my/id/eprint/17878/
Description
Summary:In the daily practice of forensic pathology, sudden cardiac death (SCD) is a diagnostic challenge. Our aim was to determine the usefulness of blood biomarkers [creatine kinase CK-MB, myoglobin, troponin I and T (cTn-T & T), and lactate dehydrogenase] measured by immunoassay technique, in the postmortem diagnosis of SCD. Two groups were compared, 20 corpses with SCD and 8 controls. Statistical significance was determined by variance analysis procedures, with a post hoc Tukey multiple range test for comparison of means (P <0.05). SCD cases showed significantly higher levels (P <0.05) of cTn-T and cTn-I compared to the control group. Although only cases within the first 8 hours of postmortem interval were included, and the control group consisted mainly of violent death cases, our results suggest that blood troponin levels may be useful to support a diagnosis of SCD.