Organotin(IV) complexes of 2-hydroxyacetophenone-N(4)-cyclohexylthiosemicarbazone (H2dact): Synthesis, spectral characterization, crystal structure and biological studies
Four new organotin(IV) complexes of the type [MeSnCl(dact)] (2), [BuSnCl(dact)] (3), [PhSnCl(dact)] (4) and [Ph2Sn(dact)] (5) were synthesized by the direct reaction of 2-hydroxyacetophenone-N(4)-cyclohexylthiosemicarbazone [H2dact, (1)] and organotin(IV) chloride(s) in absolute methanol. The ligand...
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Elsevier
2012
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| Online Access: | http://ir.unimas.my/id/eprint/17703/ http://ir.unimas.my/id/eprint/17703/1/Organotin%28IV%29%20complexes%20of%202-hydroxyacetophenone-N%284%29-cyclohexylthiosemicarbazone%20%28abstract%29.pdf |
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| author | Affan, Md. Abu Salam, Md. Abdus Fasihuddin, Badruddin Ahmad White, Fraser Hapipah M., Ali |
| author_facet | Affan, Md. Abu Salam, Md. Abdus Fasihuddin, Badruddin Ahmad White, Fraser Hapipah M., Ali |
| author_sort | Affan, Md. Abu |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Four new organotin(IV) complexes of the type [MeSnCl(dact)] (2), [BuSnCl(dact)] (3), [PhSnCl(dact)] (4) and [Ph2Sn(dact)] (5) were synthesized by the direct reaction of 2-hydroxyacetophenone-N(4)-cyclohexylthiosemicarbazone [H2dact, (1)] and organotin(IV) chloride(s) in absolute methanol. The ligand [H2dact, (1)] and its organotin(IV) complexes (2–5) have been characterized by CHN analyses, molar conductivity, UV–Vis, FT-IR, 1H, 13C and 119Sn NMR spectral studies. The molecular structure of complex (5) has also been determined by single-crystal X-ray diffraction. The crystal structure of complex (5) showed that the ligand is doubly deprotonated at the oxygen and sulfur atoms and is coordinated to the tin(IV) atom through thiolate-S, azomethine-N and phenoxide-O atoms. X-ray diffraction studies indicated that complex (5) is a monomer and the central tin(IV) atom is five coordinated in a distorted trigonal bipyramidal geometry. The cytotoxicity of the ligand (1) as well as its organotin(IV) complexes (2–5) was studied against Artemia salina. The in vitro antibacterial activities of these compounds were also evaluated. The screening results have shown that the organotin(IV) complexes (2–5) have better antibacterial activity than the free ligand. Furthermore, it has been shown that diphenyltin(IV) derivative (5) exhibits significantly better activity than the monoorganotin(IV) derivatives (2–4). |
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| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:54:08Z |
| publishDate | 2012 |
| publisher | Elsevier |
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| spelling | unimas-177032017-09-21T02:15:15Z http://ir.unimas.my/id/eprint/17703/ Organotin(IV) complexes of 2-hydroxyacetophenone-N(4)-cyclohexylthiosemicarbazone (H2dact): Synthesis, spectral characterization, crystal structure and biological studies Affan, Md. Abu Salam, Md. Abdus Fasihuddin, Badruddin Ahmad White, Fraser Hapipah M., Ali Q Science (General) Four new organotin(IV) complexes of the type [MeSnCl(dact)] (2), [BuSnCl(dact)] (3), [PhSnCl(dact)] (4) and [Ph2Sn(dact)] (5) were synthesized by the direct reaction of 2-hydroxyacetophenone-N(4)-cyclohexylthiosemicarbazone [H2dact, (1)] and organotin(IV) chloride(s) in absolute methanol. The ligand [H2dact, (1)] and its organotin(IV) complexes (2–5) have been characterized by CHN analyses, molar conductivity, UV–Vis, FT-IR, 1H, 13C and 119Sn NMR spectral studies. The molecular structure of complex (5) has also been determined by single-crystal X-ray diffraction. The crystal structure of complex (5) showed that the ligand is doubly deprotonated at the oxygen and sulfur atoms and is coordinated to the tin(IV) atom through thiolate-S, azomethine-N and phenoxide-O atoms. X-ray diffraction studies indicated that complex (5) is a monomer and the central tin(IV) atom is five coordinated in a distorted trigonal bipyramidal geometry. The cytotoxicity of the ligand (1) as well as its organotin(IV) complexes (2–5) was studied against Artemia salina. The in vitro antibacterial activities of these compounds were also evaluated. The screening results have shown that the organotin(IV) complexes (2–5) have better antibacterial activity than the free ligand. Furthermore, it has been shown that diphenyltin(IV) derivative (5) exhibits significantly better activity than the monoorganotin(IV) derivatives (2–4). Elsevier 2012 Article PeerReviewed text en http://ir.unimas.my/id/eprint/17703/1/Organotin%28IV%29%20complexes%20of%202-hydroxyacetophenone-N%284%29-cyclohexylthiosemicarbazone%20%28abstract%29.pdf Affan, Md. Abu and Salam, Md. Abdus and Fasihuddin, Badruddin Ahmad and White, Fraser and Hapipah M., Ali (2012) Organotin(IV) complexes of 2-hydroxyacetophenone-N(4)-cyclohexylthiosemicarbazone (H2dact): Synthesis, spectral characterization, crystal structure and biological studies. Inorganica Chimica Acta, 387. pp. 219-225. ISSN 0020-1693 http://www.sciencedirect.com/science/article/pii/S0020169312000217 doi : 10.1016/j.ica.2012.01.020 |
| spellingShingle | Q Science (General) Affan, Md. Abu Salam, Md. Abdus Fasihuddin, Badruddin Ahmad White, Fraser Hapipah M., Ali Organotin(IV) complexes of 2-hydroxyacetophenone-N(4)-cyclohexylthiosemicarbazone (H2dact): Synthesis, spectral characterization, crystal structure and biological studies |
| title | Organotin(IV) complexes of 2-hydroxyacetophenone-N(4)-cyclohexylthiosemicarbazone (H2dact): Synthesis, spectral characterization, crystal structure and biological studies |
| title_full | Organotin(IV) complexes of 2-hydroxyacetophenone-N(4)-cyclohexylthiosemicarbazone (H2dact): Synthesis, spectral characterization, crystal structure and biological studies |
| title_fullStr | Organotin(IV) complexes of 2-hydroxyacetophenone-N(4)-cyclohexylthiosemicarbazone (H2dact): Synthesis, spectral characterization, crystal structure and biological studies |
| title_full_unstemmed | Organotin(IV) complexes of 2-hydroxyacetophenone-N(4)-cyclohexylthiosemicarbazone (H2dact): Synthesis, spectral characterization, crystal structure and biological studies |
| title_short | Organotin(IV) complexes of 2-hydroxyacetophenone-N(4)-cyclohexylthiosemicarbazone (H2dact): Synthesis, spectral characterization, crystal structure and biological studies |
| title_sort | organotin(iv) complexes of 2-hydroxyacetophenone-n(4)-cyclohexylthiosemicarbazone (h2dact): synthesis, spectral characterization, crystal structure and biological studies |
| topic | Q Science (General) |
| url | http://ir.unimas.my/id/eprint/17703/ http://ir.unimas.my/id/eprint/17703/ http://ir.unimas.my/id/eprint/17703/ http://ir.unimas.my/id/eprint/17703/1/Organotin%28IV%29%20complexes%20of%202-hydroxyacetophenone-N%284%29-cyclohexylthiosemicarbazone%20%28abstract%29.pdf |