Lineage diversification of pigeon paramyxovirus effect re-emergence potential in chickens
Genotype VI-paramyxovirus (GVI-PMV1) is a major cause of epidemic Newcastle-like disease in Columbiformes. This genotype of avian paramyxovirus type 1 has diversified rapidly since its introduction into the US in 1982 resulting in two extant lineages, which have different population growth propertie...
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| Format: | Article |
| Language: | English |
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BioMed Central
2014
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| Online Access: | http://ir.unimas.my/id/eprint/17691/ http://ir.unimas.my/id/eprint/17691/1/Lineagediversification%20ofpigeonparamyxoviruseffectre-emergence%20%28abstract%29.pdf |
| _version_ | 1848838345156722688 |
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| author | Yee, Ling Chong Oekyung, Kim Ross, Mary |
| author_facet | Yee, Ling Chong Oekyung, Kim Ross, Mary |
| author_sort | Yee, Ling Chong |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Genotype VI-paramyxovirus (GVI-PMV1) is a major cause of epidemic Newcastle-like disease in Columbiformes. This genotype of avian paramyxovirus type 1 has diversified rapidly since its introduction into the US in 1982 resulting in two extant lineages, which have different population growth properties. Although some GVI-PMV1s replicate poorly in chickens, it is possible that variants with different replicative or pathogenic potential in chickens exist among the genetically-diverse GVI-PMV1s strains. To determine if variants of Columbiform GVI-PMV1 with different phylogenetic affiliations have distinct phenotypic properties in chickens, we investigated the replicative properties of 10 naturally circulating pigeon-derived isolates representing four subgroups of GVI-PMV1 in primary chicken lung epithelial cells and in chicken embryos. Our data demonstrate that GVI-PMV1 variants have different infection phenotypes in their chicken source host and that properties reflect subgroup affiliation. These subgroup replicative properties are consistent with observed dynamics of viral population growth. |
| first_indexed | 2025-11-15T06:54:04Z |
| format | Article |
| id | unimas-17691 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:54:04Z |
| publishDate | 2014 |
| publisher | BioMed Central |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-176912017-09-20T08:19:44Z http://ir.unimas.my/id/eprint/17691/ Lineage diversification of pigeon paramyxovirus effect re-emergence potential in chickens Yee, Ling Chong Oekyung, Kim Ross, Mary Q Science (General) Genotype VI-paramyxovirus (GVI-PMV1) is a major cause of epidemic Newcastle-like disease in Columbiformes. This genotype of avian paramyxovirus type 1 has diversified rapidly since its introduction into the US in 1982 resulting in two extant lineages, which have different population growth properties. Although some GVI-PMV1s replicate poorly in chickens, it is possible that variants with different replicative or pathogenic potential in chickens exist among the genetically-diverse GVI-PMV1s strains. To determine if variants of Columbiform GVI-PMV1 with different phylogenetic affiliations have distinct phenotypic properties in chickens, we investigated the replicative properties of 10 naturally circulating pigeon-derived isolates representing four subgroups of GVI-PMV1 in primary chicken lung epithelial cells and in chicken embryos. Our data demonstrate that GVI-PMV1 variants have different infection phenotypes in their chicken source host and that properties reflect subgroup affiliation. These subgroup replicative properties are consistent with observed dynamics of viral population growth. BioMed Central 2014 Article PeerReviewed text en http://ir.unimas.my/id/eprint/17691/1/Lineagediversification%20ofpigeonparamyxoviruseffectre-emergence%20%28abstract%29.pdf Yee, Ling Chong and Oekyung, Kim and Ross, Mary (2014) Lineage diversification of pigeon paramyxovirus effect re-emergence potential in chickens. Virology Journal, 462. pp. 309-317. ISSN 1743422X http://www.sciencedirect.com/science/article/pii/S0042682214002682 doi : 10.1016/j.virol.2014.06.007 |
| spellingShingle | Q Science (General) Yee, Ling Chong Oekyung, Kim Ross, Mary Lineage diversification of pigeon paramyxovirus effect re-emergence potential in chickens |
| title | Lineage diversification of pigeon paramyxovirus effect re-emergence potential in chickens |
| title_full | Lineage diversification of pigeon paramyxovirus effect re-emergence potential in chickens |
| title_fullStr | Lineage diversification of pigeon paramyxovirus effect re-emergence potential in chickens |
| title_full_unstemmed | Lineage diversification of pigeon paramyxovirus effect re-emergence potential in chickens |
| title_short | Lineage diversification of pigeon paramyxovirus effect re-emergence potential in chickens |
| title_sort | lineage diversification of pigeon paramyxovirus effect re-emergence potential in chickens |
| topic | Q Science (General) |
| url | http://ir.unimas.my/id/eprint/17691/ http://ir.unimas.my/id/eprint/17691/ http://ir.unimas.my/id/eprint/17691/ http://ir.unimas.my/id/eprint/17691/1/Lineagediversification%20ofpigeonparamyxoviruseffectre-emergence%20%28abstract%29.pdf |