Expression of Selected Inflammatory Cytokine Genes in Bladder Biopsies
Besides the deregulation of oncogene and tumour suppressor gene, bladder carcinoma can also be caused by inflammation. To date, the association of inflammatory cytokines with carcinoma of the bladder (especially the transitional cell carcinomas) is not fully understood. In this study, we report an...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universiti Malaysia Sarawak, (UNIMAS)
2013
|
| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/16914/ http://ir.unimas.my/id/eprint/16914/1/Expression%20of%20Selected%20Inflammatory%20Cytokine%20%28abstract%29.pdf |
| _version_ | 1848838167868735488 |
|---|---|
| author | Sim, Edmund U. H. Nur Diana, Binti Anuar Teng-Aik, Ong Guan-Chou, Teh |
| author_facet | Sim, Edmund U. H. Nur Diana, Binti Anuar Teng-Aik, Ong Guan-Chou, Teh |
| author_sort | Sim, Edmund U. H. |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Besides the deregulation of oncogene and tumour suppressor gene, bladder carcinoma can also be caused by
inflammation. To date, the association of inflammatory cytokines with carcinoma of the bladder (especially the
transitional cell carcinomas) is not fully understood. In this study, we report an attempt to examine expression
patterns of pro- and anti- inflammatory cytokine genes from normal and tumour tissue biopsies of the human
bladder. Our molecular assays involved the use of the GeneXP™ Human Cyto-3 kit and the Reverse
Transcription – Polymerase Chain Reaction test. Due to limitation in our experimental process, mainly attributed
by inconsistencies in the results obtained between the two assay systems, we cannot reach a conclusion
regarding the association of the six selected inflammatory cytokine genes (IL-8, IL-12A, IL-18, TGF-β1, TGF-
β2, and TGF-β3) with bladder carcinoma. However, our data provided early novel evidence of expression of
four inflammatory cytokine genes, namely IL-12A, TGF-β1, TGF-β2, and TGF-β3 in tissues derived from the
human bladder. |
| first_indexed | 2025-11-15T06:51:15Z |
| format | Article |
| id | unimas-16914 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:51:15Z |
| publishDate | 2013 |
| publisher | Universiti Malaysia Sarawak, (UNIMAS) |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-169142017-07-18T07:53:32Z http://ir.unimas.my/id/eprint/16914/ Expression of Selected Inflammatory Cytokine Genes in Bladder Biopsies Sim, Edmund U. H. Nur Diana, Binti Anuar Teng-Aik, Ong Guan-Chou, Teh RC0254 Neoplasms. Tumors. Oncology (including Cancer) Besides the deregulation of oncogene and tumour suppressor gene, bladder carcinoma can also be caused by inflammation. To date, the association of inflammatory cytokines with carcinoma of the bladder (especially the transitional cell carcinomas) is not fully understood. In this study, we report an attempt to examine expression patterns of pro- and anti- inflammatory cytokine genes from normal and tumour tissue biopsies of the human bladder. Our molecular assays involved the use of the GeneXP™ Human Cyto-3 kit and the Reverse Transcription – Polymerase Chain Reaction test. Due to limitation in our experimental process, mainly attributed by inconsistencies in the results obtained between the two assay systems, we cannot reach a conclusion regarding the association of the six selected inflammatory cytokine genes (IL-8, IL-12A, IL-18, TGF-β1, TGF- β2, and TGF-β3) with bladder carcinoma. However, our data provided early novel evidence of expression of four inflammatory cytokine genes, namely IL-12A, TGF-β1, TGF-β2, and TGF-β3 in tissues derived from the human bladder. Universiti Malaysia Sarawak, (UNIMAS) 2013 Article PeerReviewed text en http://ir.unimas.my/id/eprint/16914/1/Expression%20of%20Selected%20Inflammatory%20Cytokine%20%28abstract%29.pdf Sim, Edmund U. H. and Nur Diana, Binti Anuar and Teng-Aik, Ong and Guan-Chou, Teh (2013) Expression of Selected Inflammatory Cytokine Genes in Bladder Biopsies. Borneo Journal of Resource Science and Technology, 3 (2). pp. 15-20. ISSN 229-9769 http://www.bjrst.unimas.my/ |
| spellingShingle | RC0254 Neoplasms. Tumors. Oncology (including Cancer) Sim, Edmund U. H. Nur Diana, Binti Anuar Teng-Aik, Ong Guan-Chou, Teh Expression of Selected Inflammatory Cytokine Genes in Bladder Biopsies |
| title | Expression of Selected Inflammatory Cytokine Genes in Bladder Biopsies |
| title_full | Expression of Selected Inflammatory Cytokine Genes in Bladder Biopsies |
| title_fullStr | Expression of Selected Inflammatory Cytokine Genes in Bladder Biopsies |
| title_full_unstemmed | Expression of Selected Inflammatory Cytokine Genes in Bladder Biopsies |
| title_short | Expression of Selected Inflammatory Cytokine Genes in Bladder Biopsies |
| title_sort | expression of selected inflammatory cytokine genes in bladder biopsies |
| topic | RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| url | http://ir.unimas.my/id/eprint/16914/ http://ir.unimas.my/id/eprint/16914/ http://ir.unimas.my/id/eprint/16914/1/Expression%20of%20Selected%20Inflammatory%20Cytokine%20%28abstract%29.pdf |