Overexpression of WNT2 and TSG101 genes in colorectal carcinoma
Colorectal carcinoma (CRC) arises as a result of mutational activation of oncogenes coupled with inactivation of tumour suppressor genes. Mutations in APC, K-ras and p53 have been commonly reported. In a previous study by our group, the tumour susceptibility gene 101 (TSG101) were found to be per...
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| Format: | Article |
| Language: | English |
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Malaysian Society of Parasitology and Tropical Medicine
2008
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| Online Access: | http://ir.unimas.my/id/eprint/16909/ http://ir.unimas.my/id/eprint/16909/1/Overexpression.pdf |
| _version_ | 1848838166694330368 |
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| author | Ma, Xiang Ru Sim, Edmund U. H. Balraj, Pauline Lim, Patricia Rahman, Jamal |
| author_facet | Ma, Xiang Ru Sim, Edmund U. H. Balraj, Pauline Lim, Patricia Rahman, Jamal |
| author_sort | Ma, Xiang Ru |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Colorectal carcinoma (CRC) arises as a result of mutational activation of oncogenes
coupled with inactivation of tumour suppressor genes. Mutations in APC, K-ras and p53 have
been commonly reported. In a previous study by our group, the tumour susceptibility gene 101
(TSG101) were found to be persistently upregulated in CRC cases. TSG101 was reported to be
closely related to cancers of the breast, brain and colon, and its overexpression in human papillary
thyroid carcinomas and ovarian carcinomas had previously been reported. The wingless-type
MMTV integration site family member 2 (WNT2) is potentially important in the Wnt/β-catenin
pathway and upregulation of WNT2 is not uncommon in human cancers. In this study, we report
the investigation for mutation(s) and expression pattern(s) of WNT2 and TSG101, in an effort to
further understand their role(s) in CRC tumourigenesis. Our results revealed no mutation in these
genes, despite their persistent upregulation in CRC cases studied. |
| first_indexed | 2025-11-15T06:51:14Z |
| format | Article |
| id | unimas-16909 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:51:14Z |
| publishDate | 2008 |
| publisher | Malaysian Society of Parasitology and Tropical Medicine |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-169092022-01-20T00:55:22Z http://ir.unimas.my/id/eprint/16909/ Overexpression of WNT2 and TSG101 genes in colorectal carcinoma Ma, Xiang Ru Sim, Edmund U. H. Balraj, Pauline Lim, Patricia Rahman, Jamal Q Science (General) RC0254 Neoplasms. Tumors. Oncology (including Cancer) Colorectal carcinoma (CRC) arises as a result of mutational activation of oncogenes coupled with inactivation of tumour suppressor genes. Mutations in APC, K-ras and p53 have been commonly reported. In a previous study by our group, the tumour susceptibility gene 101 (TSG101) were found to be persistently upregulated in CRC cases. TSG101 was reported to be closely related to cancers of the breast, brain and colon, and its overexpression in human papillary thyroid carcinomas and ovarian carcinomas had previously been reported. The wingless-type MMTV integration site family member 2 (WNT2) is potentially important in the Wnt/β-catenin pathway and upregulation of WNT2 is not uncommon in human cancers. In this study, we report the investigation for mutation(s) and expression pattern(s) of WNT2 and TSG101, in an effort to further understand their role(s) in CRC tumourigenesis. Our results revealed no mutation in these genes, despite their persistent upregulation in CRC cases studied. Malaysian Society of Parasitology and Tropical Medicine 2008-05 Article PeerReviewed text en http://ir.unimas.my/id/eprint/16909/1/Overexpression.pdf Ma, Xiang Ru and Sim, Edmund U. H. and Balraj, Pauline and Lim, Patricia and Rahman, Jamal (2008) Overexpression of WNT2 and TSG101 genes in colorectal carcinoma. Tropical Biomedicine, 25 (1). pp. 46-57. ISSN 0127-5720 https://www.researchgate.net/publication/234017521 |
| spellingShingle | Q Science (General) RC0254 Neoplasms. Tumors. Oncology (including Cancer) Ma, Xiang Ru Sim, Edmund U. H. Balraj, Pauline Lim, Patricia Rahman, Jamal Overexpression of WNT2 and TSG101 genes in colorectal carcinoma |
| title | Overexpression of WNT2 and TSG101 genes in colorectal
carcinoma |
| title_full | Overexpression of WNT2 and TSG101 genes in colorectal
carcinoma |
| title_fullStr | Overexpression of WNT2 and TSG101 genes in colorectal
carcinoma |
| title_full_unstemmed | Overexpression of WNT2 and TSG101 genes in colorectal
carcinoma |
| title_short | Overexpression of WNT2 and TSG101 genes in colorectal
carcinoma |
| title_sort | overexpression of wnt2 and tsg101 genes in colorectal
carcinoma |
| topic | Q Science (General) RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| url | http://ir.unimas.my/id/eprint/16909/ http://ir.unimas.my/id/eprint/16909/ http://ir.unimas.my/id/eprint/16909/1/Overexpression.pdf |