Differential expression of a subset of ribosomal protein genes in cell lines derived from human nasopharyngeal epithelium
Extraribosomal functions of human ribosomal proteins (RPs) include the regulation of cellular growth and differentiation, and are inferred from studies that linked congenital disorders and cancer to the deregulated expression of RP genes. We have previously shown the upregulation and downregulation...
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| Format: | Article |
| Language: | English |
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The Japan Society of Human Genetics
2010
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| Online Access: | http://ir.unimas.my/id/eprint/16901/ http://ir.unimas.my/id/eprint/16901/1/Differential%20expression.pdf |
| _version_ | 1848838164519583744 |
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| author | Ui, Edmund Hang Sim Chow, Hiang Ang Ng, Ching Ching Lee, Choon Weng Narayanan, Kumaran |
| author_facet | Ui, Edmund Hang Sim Chow, Hiang Ang Ng, Ching Ching Lee, Choon Weng Narayanan, Kumaran |
| author_sort | Ui, Edmund Hang Sim |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Extraribosomal functions of human ribosomal proteins (RPs) include the regulation of cellular growth and differentiation, and are inferred from studies that linked congenital disorders and cancer to the deregulated expression of RP genes. We have previously shown the upregulation and downregulation of RP genes in tumors of colorectal and nasopharyngeal carcinomas (NPCs), respectively. Herein, we show that a subset of RP genes for the large ribosomal subunit is differentially expressed among cell lines derived from the human nasopharyngeal epithelium. Three such genes (RPL27, RPL37a and RPL41) were found to be significantly downregulated in all cell lines derived from NPC tissues compared with a nonmalignant nasopharyngeal
epithelial cell line. The expression of RPL37a and RPL41 genes in human nasopharyngeal tissues has not been reported previously. Our findings support earlier suspicions on the existence of NPC-associated RP genes, and indicate their importance in human nasopharyngeal organogenesis. |
| first_indexed | 2025-11-15T06:51:12Z |
| format | Article |
| id | unimas-16901 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:51:12Z |
| publishDate | 2010 |
| publisher | The Japan Society of Human Genetics |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-169012022-03-21T07:52:18Z http://ir.unimas.my/id/eprint/16901/ Differential expression of a subset of ribosomal protein genes in cell lines derived from human nasopharyngeal epithelium Ui, Edmund Hang Sim Chow, Hiang Ang Ng, Ching Ching Lee, Choon Weng Narayanan, Kumaran Q Science (General) Extraribosomal functions of human ribosomal proteins (RPs) include the regulation of cellular growth and differentiation, and are inferred from studies that linked congenital disorders and cancer to the deregulated expression of RP genes. We have previously shown the upregulation and downregulation of RP genes in tumors of colorectal and nasopharyngeal carcinomas (NPCs), respectively. Herein, we show that a subset of RP genes for the large ribosomal subunit is differentially expressed among cell lines derived from the human nasopharyngeal epithelium. Three such genes (RPL27, RPL37a and RPL41) were found to be significantly downregulated in all cell lines derived from NPC tissues compared with a nonmalignant nasopharyngeal epithelial cell line. The expression of RPL37a and RPL41 genes in human nasopharyngeal tissues has not been reported previously. Our findings support earlier suspicions on the existence of NPC-associated RP genes, and indicate their importance in human nasopharyngeal organogenesis. The Japan Society of Human Genetics 2010 Article PeerReviewed text en http://ir.unimas.my/id/eprint/16901/1/Differential%20expression.pdf Ui, Edmund Hang Sim and Chow, Hiang Ang and Ng, Ching Ching and Lee, Choon Weng and Narayanan, Kumaran (2010) Differential expression of a subset of ribosomal protein genes in cell lines derived from human nasopharyngeal epithelium. Journal of Human Genetics (55). pp. 118-120. ISSN 1434-5161 https://www.researchgate.net/publication/38114671 10.1038/jhg.2009.124 |
| spellingShingle | Q Science (General) Ui, Edmund Hang Sim Chow, Hiang Ang Ng, Ching Ching Lee, Choon Weng Narayanan, Kumaran Differential expression of a subset of ribosomal protein genes in cell lines derived from human nasopharyngeal epithelium |
| title | Differential expression of a subset of ribosomal protein genes in cell lines derived from human nasopharyngeal epithelium |
| title_full | Differential expression of a subset of ribosomal protein genes in cell lines derived from human nasopharyngeal epithelium |
| title_fullStr | Differential expression of a subset of ribosomal protein genes in cell lines derived from human nasopharyngeal epithelium |
| title_full_unstemmed | Differential expression of a subset of ribosomal protein genes in cell lines derived from human nasopharyngeal epithelium |
| title_short | Differential expression of a subset of ribosomal protein genes in cell lines derived from human nasopharyngeal epithelium |
| title_sort | differential expression of a subset of ribosomal protein genes in cell lines derived from human nasopharyngeal epithelium |
| topic | Q Science (General) |
| url | http://ir.unimas.my/id/eprint/16901/ http://ir.unimas.my/id/eprint/16901/ http://ir.unimas.my/id/eprint/16901/ http://ir.unimas.my/id/eprint/16901/1/Differential%20expression.pdf |