Haematological Reference Intervals in a Multiethnic Population
Introduction: Similar to other populations, full blood count reference (FBC) intervals in Malaysia are generally derived from non-Malaysian subjects. However, numerous studies have shown significant differences between and within populations supporting the need for population specific intervals....
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| Format: | Article |
| Language: | English |
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Plos One Publishing
2014
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| Online Access: | http://ir.unimas.my/id/eprint/16590/ http://ir.unimas.my/id/eprint/16590/1/Haematological%20Reference%20Intervals%20in%20a%20Multiethnic%28abstract%29.pdf |
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| author | Angeli, Ambayya Ting, Anselm Su Nadila Haryani, Osman Nik Rosnita, Nik-Samsudin Khadijah, Khalid Kian, Meng Chang Jameela, Sathar Jay Suriar, Rajasuriar Subramanian, Yegappan |
| author_facet | Angeli, Ambayya Ting, Anselm Su Nadila Haryani, Osman Nik Rosnita, Nik-Samsudin Khadijah, Khalid Kian, Meng Chang Jameela, Sathar Jay Suriar, Rajasuriar Subramanian, Yegappan |
| author_sort | Angeli, Ambayya |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Introduction: Similar to other populations, full blood count reference (FBC) intervals in Malaysia are generally derived from non-Malaysian subjects. However, numerous studies have shown significant differences between and within populations supporting the need for population specific intervals.
Methods: Two thousand seven hundred twenty five apparently healthy adults comprising all ages, both genders and three principal races were recruited through voluntary participation. FBC was performed on two analysers, Sysmex XE-5000 and Unicel DxH 800, in addition to blood smears and haemoglobin analysis. Serum ferritin, soluble transferrin receptor and Creactive protein assays were performed in selected subjects. All parameters of qualified subjects were tested for normality
followed by determination of reference intervals, measures of central tendency and dispersion along with point estimates for each subgroup.
Results: Complete data was available in 2440 subjects of whom 56% (907 women and 469 men) were included in reference interval calculation. Compared to other populations there were significant differences for haemoglobin, red blood cell count, platelet count and haematocrit in Malaysians. There were differences between men and women, and between younger and older men; unlike in other populations, haemoglobin was similar in younger and older women. However ethnicity and smoking had little impact. 70% of anemia in premenopausal women, 24% in postmenopausal women and 20% of males is attributable to iron deficiency. There was excellent correlation between Sysmex XE-5000 and Unicel DxH 800.
Conclusion: Our data confirms the importance of population specific haematological parameters and supports the need for local guidelines rather than adoption of generalised reference intervals and cut-offs. |
| first_indexed | 2025-11-15T06:50:07Z |
| format | Article |
| id | unimas-16590 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:50:07Z |
| publishDate | 2014 |
| publisher | Plos One Publishing |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-165902017-06-12T03:37:50Z http://ir.unimas.my/id/eprint/16590/ Haematological Reference Intervals in a Multiethnic Population Angeli, Ambayya Ting, Anselm Su Nadila Haryani, Osman Nik Rosnita, Nik-Samsudin Khadijah, Khalid Kian, Meng Chang Jameela, Sathar Jay Suriar, Rajasuriar Subramanian, Yegappan R Medicine (General) RA0421 Public health. Hygiene. Preventive Medicine Introduction: Similar to other populations, full blood count reference (FBC) intervals in Malaysia are generally derived from non-Malaysian subjects. However, numerous studies have shown significant differences between and within populations supporting the need for population specific intervals. Methods: Two thousand seven hundred twenty five apparently healthy adults comprising all ages, both genders and three principal races were recruited through voluntary participation. FBC was performed on two analysers, Sysmex XE-5000 and Unicel DxH 800, in addition to blood smears and haemoglobin analysis. Serum ferritin, soluble transferrin receptor and Creactive protein assays were performed in selected subjects. All parameters of qualified subjects were tested for normality followed by determination of reference intervals, measures of central tendency and dispersion along with point estimates for each subgroup. Results: Complete data was available in 2440 subjects of whom 56% (907 women and 469 men) were included in reference interval calculation. Compared to other populations there were significant differences for haemoglobin, red blood cell count, platelet count and haematocrit in Malaysians. There were differences between men and women, and between younger and older men; unlike in other populations, haemoglobin was similar in younger and older women. However ethnicity and smoking had little impact. 70% of anemia in premenopausal women, 24% in postmenopausal women and 20% of males is attributable to iron deficiency. There was excellent correlation between Sysmex XE-5000 and Unicel DxH 800. Conclusion: Our data confirms the importance of population specific haematological parameters and supports the need for local guidelines rather than adoption of generalised reference intervals and cut-offs. Plos One Publishing 2014 Article PeerReviewed text en http://ir.unimas.my/id/eprint/16590/1/Haematological%20Reference%20Intervals%20in%20a%20Multiethnic%28abstract%29.pdf Angeli, Ambayya and Ting, Anselm Su and Nadila Haryani, Osman and Nik Rosnita, Nik-Samsudin and Khadijah, Khalid and Kian, Meng Chang and Jameela, Sathar and Jay Suriar, Rajasuriar and Subramanian, Yegappan (2014) Haematological Reference Intervals in a Multiethnic Population. PLoS ONE, 9 (3). ISSN 1932-6203 http://journals.plos.org/plosone/article/authors?id=10.1371/journal.pone.0091968 doi:10.1371/journal.pone.0091968 |
| spellingShingle | R Medicine (General) RA0421 Public health. Hygiene. Preventive Medicine Angeli, Ambayya Ting, Anselm Su Nadila Haryani, Osman Nik Rosnita, Nik-Samsudin Khadijah, Khalid Kian, Meng Chang Jameela, Sathar Jay Suriar, Rajasuriar Subramanian, Yegappan Haematological Reference Intervals in a Multiethnic Population |
| title | Haematological Reference Intervals in a Multiethnic Population |
| title_full | Haematological Reference Intervals in a Multiethnic Population |
| title_fullStr | Haematological Reference Intervals in a Multiethnic Population |
| title_full_unstemmed | Haematological Reference Intervals in a Multiethnic Population |
| title_short | Haematological Reference Intervals in a Multiethnic Population |
| title_sort | haematological reference intervals in a multiethnic population |
| topic | R Medicine (General) RA0421 Public health. Hygiene. Preventive Medicine |
| url | http://ir.unimas.my/id/eprint/16590/ http://ir.unimas.my/id/eprint/16590/ http://ir.unimas.my/id/eprint/16590/ http://ir.unimas.my/id/eprint/16590/1/Haematological%20Reference%20Intervals%20in%20a%20Multiethnic%28abstract%29.pdf |