Cloning and expression of prM and it's use to distinguish host immune responses against dengue virus and Japanese encephalitis virus infections
All flaviviruses share common epitopes on the envelope protein (E) that results in extensive crossreactions in serological tests. /this makes it difficult to distinguish between immune responses against dengue virus (DENV) and Japanese encephalitis virus (JEV), particularly in regions where these vi...
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| Format: | Thesis |
| Language: | English |
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2001
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| Online Access: | http://ir.unimas.my/id/eprint/16585/ http://ir.unimas.my/id/eprint/16585/1/Wong%20Seok%20ft.pdf |
| _version_ | 1848838094948663296 |
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| author | Wang, Seok Mui |
| author_facet | Wang, Seok Mui |
| author_sort | Wang, Seok Mui |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | All flaviviruses share common epitopes on the envelope protein (E) that results in extensive crossreactions in serological tests. /this makes it difficult to distinguish between immune responses against dengue virus (DENV) and Japanese encephalitis virus (JEV), particularly in regions where these viruses co-circulate. We have demonstrated that DENV and JEV have unique epitopes on the prM. By detecting prM specific IgG, it is possible to distinguish between DENV and JEV infection. Current approach used in seroanalysis of DENV and JEV infections is based on antigens derived from the whole viral antigens. |
| first_indexed | 2025-11-15T06:50:06Z |
| format | Thesis |
| id | unimas-16585 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:50:06Z |
| publishDate | 2001 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-165852023-11-21T05:21:20Z http://ir.unimas.my/id/eprint/16585/ Cloning and expression of prM and it's use to distinguish host immune responses against dengue virus and Japanese encephalitis virus infections Wang, Seok Mui RA Public aspects of medicine All flaviviruses share common epitopes on the envelope protein (E) that results in extensive crossreactions in serological tests. /this makes it difficult to distinguish between immune responses against dengue virus (DENV) and Japanese encephalitis virus (JEV), particularly in regions where these viruses co-circulate. We have demonstrated that DENV and JEV have unique epitopes on the prM. By detecting prM specific IgG, it is possible to distinguish between DENV and JEV infection. Current approach used in seroanalysis of DENV and JEV infections is based on antigens derived from the whole viral antigens. 2001 Thesis NonPeerReviewed text en http://ir.unimas.my/id/eprint/16585/1/Wong%20Seok%20ft.pdf Wang, Seok Mui (2001) Cloning and expression of prM and it's use to distinguish host immune responses against dengue virus and Japanese encephalitis virus infections. Masters thesis, Universiti Malaysia Sarawak, (UNIMAS). |
| spellingShingle | RA Public aspects of medicine Wang, Seok Mui Cloning and expression of prM and it's use to distinguish host immune responses against dengue virus and Japanese encephalitis virus infections |
| title | Cloning and expression of prM and it's use to distinguish host immune responses against dengue virus and Japanese encephalitis virus infections |
| title_full | Cloning and expression of prM and it's use to distinguish host immune responses against dengue virus and Japanese encephalitis virus infections |
| title_fullStr | Cloning and expression of prM and it's use to distinguish host immune responses against dengue virus and Japanese encephalitis virus infections |
| title_full_unstemmed | Cloning and expression of prM and it's use to distinguish host immune responses against dengue virus and Japanese encephalitis virus infections |
| title_short | Cloning and expression of prM and it's use to distinguish host immune responses against dengue virus and Japanese encephalitis virus infections |
| title_sort | cloning and expression of prm and it's use to distinguish host immune responses against dengue virus and japanese encephalitis virus infections |
| topic | RA Public aspects of medicine |
| url | http://ir.unimas.my/id/eprint/16585/ http://ir.unimas.my/id/eprint/16585/1/Wong%20Seok%20ft.pdf |