Early detection of C-reactive protein and von Willebrand factor levels in Malaysian patients with acute coronary syndrome
Background: Diagnosing acute coronary syndrome (ACS) remains a challenge in patients presenting at early phase of hospitalization. We hypothesized that inflammatory markers of plaque rupture could accurately identifying ACS patients from stable coronary artery diseases (CAD). Materials and methods:...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Medknow Publications and Media Pvt. Ltd
2013
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| Online Access: | http://ir.unimas.my/id/eprint/16416/ http://ir.unimas.my/id/eprint/16416/1/Early.pdf |
| _version_ | 1848838062180663296 |
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| author | W.N, Tiong Edmund, Ui Hang Sim Alan, Yean Yip Fong |
| author_facet | W.N, Tiong Edmund, Ui Hang Sim Alan, Yean Yip Fong |
| author_sort | W.N, Tiong |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Background: Diagnosing acute coronary syndrome (ACS) remains a challenge in patients presenting at early phase of hospitalization. We hypothesized that inflammatory markers of plaque rupture could accurately identifying ACS patients from stable coronary artery diseases (CAD). Materials and methods: The serum and peripheral blood gene expression levels of C-reactive protein (CRP) and von Willebrand factor (vWF) in multiethnic Malaysian patients (n = 7) admitted with early hospitalization of ACS was evaluated. Nine patients with stable coronary artery disease without previous history of ACS were enrolled as controls. Results: Serum and peripheral blood mRNA levels of CRP and vWF were significantly higher in ACS compared to control groups (P < 0.05). Conclusions: Elevated levels of these markers in ACS may reflect an acute phase response due to endothelial dysfunction. Both CRP and vWF may add to the list of useful markers for early detection of ACS in hospitals of developing countries. |
| first_indexed | 2025-11-15T06:49:35Z |
| format | Article |
| id | unimas-16416 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:49:35Z |
| publishDate | 2013 |
| publisher | Medknow Publications and Media Pvt. Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-164162021-06-05T05:25:56Z http://ir.unimas.my/id/eprint/16416/ Early detection of C-reactive protein and von Willebrand factor levels in Malaysian patients with acute coronary syndrome W.N, Tiong Edmund, Ui Hang Sim Alan, Yean Yip Fong QD Chemistry RB Pathology Background: Diagnosing acute coronary syndrome (ACS) remains a challenge in patients presenting at early phase of hospitalization. We hypothesized that inflammatory markers of plaque rupture could accurately identifying ACS patients from stable coronary artery diseases (CAD). Materials and methods: The serum and peripheral blood gene expression levels of C-reactive protein (CRP) and von Willebrand factor (vWF) in multiethnic Malaysian patients (n = 7) admitted with early hospitalization of ACS was evaluated. Nine patients with stable coronary artery disease without previous history of ACS were enrolled as controls. Results: Serum and peripheral blood mRNA levels of CRP and vWF were significantly higher in ACS compared to control groups (P < 0.05). Conclusions: Elevated levels of these markers in ACS may reflect an acute phase response due to endothelial dysfunction. Both CRP and vWF may add to the list of useful markers for early detection of ACS in hospitals of developing countries. Medknow Publications and Media Pvt. Ltd 2013-03 Article PeerReviewed text en http://ir.unimas.my/id/eprint/16416/1/Early.pdf W.N, Tiong and Edmund, Ui Hang Sim and Alan, Yean Yip Fong (2013) Early detection of C-reactive protein and von Willebrand factor levels in Malaysian patients with acute coronary syndrome. Journal of Cardiovascular Disease Research, 4 (1). pp. 3-6. ISSN 0975-3583 https://www.jcdronline.org/ DOI: 10.1016/j.jcdr.2012.08.004 |
| spellingShingle | QD Chemistry RB Pathology W.N, Tiong Edmund, Ui Hang Sim Alan, Yean Yip Fong Early detection of C-reactive protein and von Willebrand factor levels in Malaysian patients with acute coronary syndrome |
| title | Early detection of C-reactive protein and von Willebrand factor levels in Malaysian patients with acute coronary syndrome |
| title_full | Early detection of C-reactive protein and von Willebrand factor levels in Malaysian patients with acute coronary syndrome |
| title_fullStr | Early detection of C-reactive protein and von Willebrand factor levels in Malaysian patients with acute coronary syndrome |
| title_full_unstemmed | Early detection of C-reactive protein and von Willebrand factor levels in Malaysian patients with acute coronary syndrome |
| title_short | Early detection of C-reactive protein and von Willebrand factor levels in Malaysian patients with acute coronary syndrome |
| title_sort | early detection of c-reactive protein and von willebrand factor levels in malaysian patients with acute coronary syndrome |
| topic | QD Chemistry RB Pathology |
| url | http://ir.unimas.my/id/eprint/16416/ http://ir.unimas.my/id/eprint/16416/ http://ir.unimas.my/id/eprint/16416/ http://ir.unimas.my/id/eprint/16416/1/Early.pdf |