Emergence potential of sylvatic dengue virus type 4 in the urban transmission cycle is restrained by vaccination and homotypic immunity
Sylvatic dengue viruses (DENV) are both evolutionarily and ecologically distinct from human DENV and are maintained in an enzootic transmission cycle. Evidence of sylvatic human infections from West Africa and Southeast Asia suggests that sylvatic DENV come into regular contact with humans. Thus, th...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Academic Press Inc.
2013
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| Online Access: | http://ir.unimas.my/id/eprint/16350/ http://ir.unimas.my/id/eprint/16350/1/Emergence%20potential%20of%20sylvatic%20dengue%20virus%20type%204%20in%20the%20urban%20transmission%20cycle%20is%20restrained%20by%20vaccination%20and%20homotypic%20immunity%20%28abstrak%29.pdf |
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| author | Durbin, Anna P. Mayer, Sandra V. Rossi, Shannan L. Amaya-Larios, Irma Y. Ramos-Castaneda, Jose Eng, Eong Ooi Cardosa, M. Jane Munoz-Jordan, Jorge L. Tesh, Robert B. Messer, William B. Weaver, Scott C. Vasilakis, Nikos |
| author_facet | Durbin, Anna P. Mayer, Sandra V. Rossi, Shannan L. Amaya-Larios, Irma Y. Ramos-Castaneda, Jose Eng, Eong Ooi Cardosa, M. Jane Munoz-Jordan, Jorge L. Tesh, Robert B. Messer, William B. Weaver, Scott C. Vasilakis, Nikos |
| author_sort | Durbin, Anna P. |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Sylvatic dengue viruses (DENV) are both evolutionarily and ecologically distinct from human DENV and are maintained in an enzootic transmission cycle. Evidence of sylvatic human infections from West Africa and Southeast Asia suggests that sylvatic DENV come into regular contact with humans. Thus, this potential of emergence into the human transmission cycle could limit the potential for eradicating this cycle with vaccines currently in late stages of development. We assessed the likelihood of sylvatic DENV-4 emergence in the face of natural immunity to current human strains and vaccination with two DENV-4 vaccine candidates. Our data indicate homotypic neutralization of sylvatic and human DENV-4 strains by human primary convalescent and vaccinee sera but limited heterotypic immunity. These results suggest that emergence of sylvatic strains into the human cycle would be limited by homotypic immunity mediated by virus neutralizing antibodies produced by natural infection or vaccination. |
| first_indexed | 2025-11-15T06:49:18Z |
| format | Article |
| id | unimas-16350 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:49:18Z |
| publishDate | 2013 |
| publisher | Academic Press Inc. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-163502017-05-22T01:44:31Z http://ir.unimas.my/id/eprint/16350/ Emergence potential of sylvatic dengue virus type 4 in the urban transmission cycle is restrained by vaccination and homotypic immunity Durbin, Anna P. Mayer, Sandra V. Rossi, Shannan L. Amaya-Larios, Irma Y. Ramos-Castaneda, Jose Eng, Eong Ooi Cardosa, M. Jane Munoz-Jordan, Jorge L. Tesh, Robert B. Messer, William B. Weaver, Scott C. Vasilakis, Nikos RC Internal medicine Sylvatic dengue viruses (DENV) are both evolutionarily and ecologically distinct from human DENV and are maintained in an enzootic transmission cycle. Evidence of sylvatic human infections from West Africa and Southeast Asia suggests that sylvatic DENV come into regular contact with humans. Thus, this potential of emergence into the human transmission cycle could limit the potential for eradicating this cycle with vaccines currently in late stages of development. We assessed the likelihood of sylvatic DENV-4 emergence in the face of natural immunity to current human strains and vaccination with two DENV-4 vaccine candidates. Our data indicate homotypic neutralization of sylvatic and human DENV-4 strains by human primary convalescent and vaccinee sera but limited heterotypic immunity. These results suggest that emergence of sylvatic strains into the human cycle would be limited by homotypic immunity mediated by virus neutralizing antibodies produced by natural infection or vaccination. Academic Press Inc. 2013-04 Article PeerReviewed text en http://ir.unimas.my/id/eprint/16350/1/Emergence%20potential%20of%20sylvatic%20dengue%20virus%20type%204%20in%20the%20urban%20transmission%20cycle%20is%20restrained%20by%20vaccination%20and%20homotypic%20immunity%20%28abstrak%29.pdf Durbin, Anna P. and Mayer, Sandra V. and Rossi, Shannan L. and Amaya-Larios, Irma Y. and Ramos-Castaneda, Jose and Eng, Eong Ooi and Cardosa, M. Jane and Munoz-Jordan, Jorge L. and Tesh, Robert B. and Messer, William B. and Weaver, Scott C. and Vasilakis, Nikos (2013) Emergence potential of sylvatic dengue virus type 4 in the urban transmission cycle is restrained by vaccination and homotypic immunity. Virology, 439 (1). pp. 34-41. ISSN 0042-6822 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622939/ DOI: 10.1016/j.virol.2013.01.018 |
| spellingShingle | RC Internal medicine Durbin, Anna P. Mayer, Sandra V. Rossi, Shannan L. Amaya-Larios, Irma Y. Ramos-Castaneda, Jose Eng, Eong Ooi Cardosa, M. Jane Munoz-Jordan, Jorge L. Tesh, Robert B. Messer, William B. Weaver, Scott C. Vasilakis, Nikos Emergence potential of sylvatic dengue virus type 4 in the urban transmission cycle is restrained by vaccination and homotypic immunity |
| title | Emergence potential of sylvatic dengue virus type 4 in the urban transmission cycle is restrained by vaccination and homotypic immunity |
| title_full | Emergence potential of sylvatic dengue virus type 4 in the urban transmission cycle is restrained by vaccination and homotypic immunity |
| title_fullStr | Emergence potential of sylvatic dengue virus type 4 in the urban transmission cycle is restrained by vaccination and homotypic immunity |
| title_full_unstemmed | Emergence potential of sylvatic dengue virus type 4 in the urban transmission cycle is restrained by vaccination and homotypic immunity |
| title_short | Emergence potential of sylvatic dengue virus type 4 in the urban transmission cycle is restrained by vaccination and homotypic immunity |
| title_sort | emergence potential of sylvatic dengue virus type 4 in the urban transmission cycle is restrained by vaccination and homotypic immunity |
| topic | RC Internal medicine |
| url | http://ir.unimas.my/id/eprint/16350/ http://ir.unimas.my/id/eprint/16350/ http://ir.unimas.my/id/eprint/16350/ http://ir.unimas.my/id/eprint/16350/1/Emergence%20potential%20of%20sylvatic%20dengue%20virus%20type%204%20in%20the%20urban%20transmission%20cycle%20is%20restrained%20by%20vaccination%20and%20homotypic%20immunity%20%28abstrak%29.pdf |