Molecular Epidemiology of Human Enterovirus 71 Strains and Recent Outbreaks in the Asia-Pacific Region: Comparative Analysis of the VP1 and VP4 Genes
This study provides a comprehensive overview of the molecular epidemiology of human enterovirus 71 (HEV71) in the Asia-Pacific region from 1997 through 2002. Phylogenetic analysis of the VP4 and VP1 genes of recent HEV71 strains indicates that several genogroups of the virus have been circulating in...
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| Format: | Article |
| Language: | English |
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NationalCenter for Biotechnology Information, U.S. National Library of Medicine
2003
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| Online Access: | http://ir.unimas.my/id/eprint/16036/ http://ir.unimas.my/id/eprint/16036/1/Molecular%20Epidemiology%20of%20Human%28abstract%29.pdf |
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| author | Cardosa, Mary Jane David, Perera Brown, Betty A. Doosung, Cheon Hung, Ming Chan Kwai, Peng Chan Haewol, Cho McMinn, Peter |
| author_facet | Cardosa, Mary Jane David, Perera Brown, Betty A. Doosung, Cheon Hung, Ming Chan Kwai, Peng Chan Haewol, Cho McMinn, Peter |
| author_sort | Cardosa, Mary Jane |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | This study provides a comprehensive overview of the molecular epidemiology of human enterovirus 71 (HEV71) in the Asia-Pacific region from 1997 through 2002. Phylogenetic analysis of the VP4 and VP1 genes of recent HEV71 strains indicates that several genogroups of the virus have been circulating in the Asia-Pacific region since 1997. The first of these recent outbreaks, described in Sarawak (Malaysian Borneo) in 1997, was caused by genogroup B3. This outbreak was followed by large outbreaks in Taiwan in 1998, caused by genogroup C2, and in Perth (Western Australia) in 1999, where viruses belonging to genogroups B3 and C2 cocirculated. Singapore, Taiwan, and Sarawak had HEV71 epidemics in 2000, caused predominantly by viruses belonging to genogroup B4; however, large numbers of fatalities were observed only in Taiwan. HEV71 was identified during an epidemic of hand, foot and mouth disease in Korea; that epidemic was found to be due to viruses constituting a new genogroup, C3. |
| first_indexed | 2025-11-15T06:48:09Z |
| format | Article |
| id | unimas-16036 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:48:09Z |
| publishDate | 2003 |
| publisher | NationalCenter for Biotechnology Information, U.S. National Library of Medicine |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-160362017-04-28T08:24:01Z http://ir.unimas.my/id/eprint/16036/ Molecular Epidemiology of Human Enterovirus 71 Strains and Recent Outbreaks in the Asia-Pacific Region: Comparative Analysis of the VP1 and VP4 Genes Cardosa, Mary Jane David, Perera Brown, Betty A. Doosung, Cheon Hung, Ming Chan Kwai, Peng Chan Haewol, Cho McMinn, Peter R Medicine (General) RA0421 Public health. Hygiene. Preventive Medicine This study provides a comprehensive overview of the molecular epidemiology of human enterovirus 71 (HEV71) in the Asia-Pacific region from 1997 through 2002. Phylogenetic analysis of the VP4 and VP1 genes of recent HEV71 strains indicates that several genogroups of the virus have been circulating in the Asia-Pacific region since 1997. The first of these recent outbreaks, described in Sarawak (Malaysian Borneo) in 1997, was caused by genogroup B3. This outbreak was followed by large outbreaks in Taiwan in 1998, caused by genogroup C2, and in Perth (Western Australia) in 1999, where viruses belonging to genogroups B3 and C2 cocirculated. Singapore, Taiwan, and Sarawak had HEV71 epidemics in 2000, caused predominantly by viruses belonging to genogroup B4; however, large numbers of fatalities were observed only in Taiwan. HEV71 was identified during an epidemic of hand, foot and mouth disease in Korea; that epidemic was found to be due to viruses constituting a new genogroup, C3. NationalCenter for Biotechnology Information, U.S. National Library of Medicine 2003-04 Article PeerReviewed text en http://ir.unimas.my/id/eprint/16036/1/Molecular%20Epidemiology%20of%20Human%28abstract%29.pdf Cardosa, Mary Jane and David, Perera and Brown, Betty A. and Doosung, Cheon and Hung, Ming Chan and Kwai, Peng Chan and Haewol, Cho and McMinn, Peter (2003) Molecular Epidemiology of Human Enterovirus 71 Strains and Recent Outbreaks in the Asia-Pacific Region: Comparative Analysis of the VP1 and VP4 Genes. Emerging Infectious Diseases, 9 (4). pp. 461-468. ISSN 1080-6059 https://wwwnc.cdc.gov/eid/ 10.3201/eid0904.020395 |
| spellingShingle | R Medicine (General) RA0421 Public health. Hygiene. Preventive Medicine Cardosa, Mary Jane David, Perera Brown, Betty A. Doosung, Cheon Hung, Ming Chan Kwai, Peng Chan Haewol, Cho McMinn, Peter Molecular Epidemiology of Human Enterovirus 71 Strains and Recent Outbreaks in the Asia-Pacific Region: Comparative Analysis of the VP1 and VP4 Genes |
| title | Molecular Epidemiology of Human Enterovirus 71 Strains and Recent Outbreaks in the Asia-Pacific Region: Comparative Analysis of the VP1 and VP4 Genes |
| title_full | Molecular Epidemiology of Human Enterovirus 71 Strains and Recent Outbreaks in the Asia-Pacific Region: Comparative Analysis of the VP1 and VP4 Genes |
| title_fullStr | Molecular Epidemiology of Human Enterovirus 71 Strains and Recent Outbreaks in the Asia-Pacific Region: Comparative Analysis of the VP1 and VP4 Genes |
| title_full_unstemmed | Molecular Epidemiology of Human Enterovirus 71 Strains and Recent Outbreaks in the Asia-Pacific Region: Comparative Analysis of the VP1 and VP4 Genes |
| title_short | Molecular Epidemiology of Human Enterovirus 71 Strains and Recent Outbreaks in the Asia-Pacific Region: Comparative Analysis of the VP1 and VP4 Genes |
| title_sort | molecular epidemiology of human enterovirus 71 strains and recent outbreaks in the asia-pacific region: comparative analysis of the vp1 and vp4 genes |
| topic | R Medicine (General) RA0421 Public health. Hygiene. Preventive Medicine |
| url | http://ir.unimas.my/id/eprint/16036/ http://ir.unimas.my/id/eprint/16036/ http://ir.unimas.my/id/eprint/16036/ http://ir.unimas.my/id/eprint/16036/1/Molecular%20Epidemiology%20of%20Human%28abstract%29.pdf |