Plasmodium falciparum: inhibition/reversal of cytoadherence of Thai isolates to melanoma cells by local immune sera
The effect of sera on the cytoadherence in vitro of Plasmodium falciparum-infected erythrocytes to melanoma cells was examined. Sera from 19 healthy individuals living in endemic malarious areas in Thailand and 24 patients with P. falciparum malaria were tested against four local P. falciparum is...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
British Society for Immunology
1998
|
| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/15884/ http://ir.unimas.my/id/eprint/15884/1/Plasmodium%20falciparum%20%28ABSTRACT%29.pdf |
| Summary: | The effect of sera on the cytoadherence in vitro of Plasmodium falciparum-infected erythrocytes to
melanoma cells was examined. Sera from 19 healthy individuals living in endemic malarious areas in
Thailand and 24 patients with P. falciparum malaria were tested against four local P. falciparum
isolates. Out of 57 sera examined, 12 (21 %) showed significant inhibition (> 50%) of cytoadherence
for at least one isolate. Anti-malarial IgG antibody titres were determined for all 57 sera and although
11 of the 12 inhibitory sera had relatively high titres, 36 out of47 sera with similarly high titres showed
no significant inhibitory activity. Convalescent sera were no more effective than corresponding acute
sera in inhibiting the cytoadherence of erythrocytes infected with any of the four heterologous
isolates examined. Sera which significantly inhibited cytoadherence were also capable of reversing
cytoadherence, and pooled plasma, from healthy individuals living in malarious areas, was effective
in significantly reversing the in vitro cytoadherence of all the five parasite isolates examined. The
results confirm the antibody mediated strain-specific nature of the inhibition of cytoadherence and
stress the difficulty in selecting immune sera potentially useful for the immunotherapy of cerebral
malaria patients in Thailand. |
|---|