Anti-Inflammatory Cytokines Predominate in Acute Human Plasmodium knowlesi Infections
Plasmodium knowlesi has entered the human population of Southeast Asia. Naturally acquired knowlesi malaria is newly described with relatively little available data, including data on the host response to infection. Therefore pre-treatment cytokine and chemokine profiles were determined for 94 P. kn...
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| Format: | Article |
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Plos One Publishing
2011
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| Online Access: | http://ir.unimas.my/id/eprint/15806/ http://ir.unimas.my/id/eprint/15806/1/Anti-Inflammatory%20Cytokines%20Predominate%20in%20Acute%20%28abstract%29.pdf |
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| author | Cox-Singh, J. Balbir, Singh Daneshvar, C. Planche, Timothy Parker-Williams, John Sanjeev, Krishna |
| author_facet | Cox-Singh, J. Balbir, Singh Daneshvar, C. Planche, Timothy Parker-Williams, John Sanjeev, Krishna |
| author_sort | Cox-Singh, J. |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Plasmodium knowlesi has entered the human population of Southeast Asia. Naturally acquired knowlesi malaria is newly described with relatively little available data, including data on the host response to infection. Therefore pre-treatment cytokine and chemokine profiles were determined for 94 P. knowlesi, and for comparison, 20, P. vivax and 22 P. falciparum, patients recruited in Malaysian Borneo. Nine, five and one patient with P. knowlesi, P. falciparum and P. vivax respectively
had complicated malaria as defined by World Health Organisation. Patients with uncomplicated P. knowlesi had lower levels of the pro-inflammatory cytokines IL-8 and TNFa than those with complicated disease (both p,0.05, Dunn’s post test, DPT). The anti-inflammatory cytokines IL-1ra and IL-10 were detected in all patients in the study. IL-1ra, the most abundant cytokine measured, correlated with parasitaemia in P. knowlesi (rs = 0.47, p = ,0.0001), P. vivax (rs = 0.61, p = 0.0042) and P.
falciparum (rs = 0.57,p = 0.0054) malaria. IL-10 correlated with parasitaemia in both P. knowlesi (rs = 0.54, p = ,0.0001) and P.
vivax (rs = 0.78, p = ,0.0001) infections. There were between group differences in soluble markers of macrophage activation
(MIP-1b and MCP-1). P. knowlesi patients had significantly lower levels of MIP-1b than P. falciparum (DPT, p = ,0.01).
Uncomplicated P. knowlesi patients had significantly lower levels of MCP-1 than uncomplicated P. falciparum patients (DPT,
p = ,0.001). There was no significant difference between complicated and uncomplicated P. knowlesi infections. MCP-1,
MIP-1b, IL-8 and TNFa increased in complicated P. knowlesi but decreased in complicated P. falciparum infections.
Descriptions of human knowlesi malaria provide a comparative means to discover mediators of pathophysiology in severe
P. knowlesi as well as P. falciparum malaria. Crucially, P. knowlesi may be the disease and experimental primate model for
severe malaria. |
| first_indexed | 2025-11-15T06:47:29Z |
| format | Article |
| id | unimas-15806 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:47:29Z |
| publishDate | 2011 |
| publisher | Plos One Publishing |
| recordtype | eprints |
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| spelling | unimas-158062017-04-04T04:42:44Z http://ir.unimas.my/id/eprint/15806/ Anti-Inflammatory Cytokines Predominate in Acute Human Plasmodium knowlesi Infections Cox-Singh, J. Balbir, Singh Daneshvar, C. Planche, Timothy Parker-Williams, John Sanjeev, Krishna Q Science (General) Plasmodium knowlesi has entered the human population of Southeast Asia. Naturally acquired knowlesi malaria is newly described with relatively little available data, including data on the host response to infection. Therefore pre-treatment cytokine and chemokine profiles were determined for 94 P. knowlesi, and for comparison, 20, P. vivax and 22 P. falciparum, patients recruited in Malaysian Borneo. Nine, five and one patient with P. knowlesi, P. falciparum and P. vivax respectively had complicated malaria as defined by World Health Organisation. Patients with uncomplicated P. knowlesi had lower levels of the pro-inflammatory cytokines IL-8 and TNFa than those with complicated disease (both p,0.05, Dunn’s post test, DPT). The anti-inflammatory cytokines IL-1ra and IL-10 were detected in all patients in the study. IL-1ra, the most abundant cytokine measured, correlated with parasitaemia in P. knowlesi (rs = 0.47, p = ,0.0001), P. vivax (rs = 0.61, p = 0.0042) and P. falciparum (rs = 0.57,p = 0.0054) malaria. IL-10 correlated with parasitaemia in both P. knowlesi (rs = 0.54, p = ,0.0001) and P. vivax (rs = 0.78, p = ,0.0001) infections. There were between group differences in soluble markers of macrophage activation (MIP-1b and MCP-1). P. knowlesi patients had significantly lower levels of MIP-1b than P. falciparum (DPT, p = ,0.01). Uncomplicated P. knowlesi patients had significantly lower levels of MCP-1 than uncomplicated P. falciparum patients (DPT, p = ,0.001). There was no significant difference between complicated and uncomplicated P. knowlesi infections. MCP-1, MIP-1b, IL-8 and TNFa increased in complicated P. knowlesi but decreased in complicated P. falciparum infections. Descriptions of human knowlesi malaria provide a comparative means to discover mediators of pathophysiology in severe P. knowlesi as well as P. falciparum malaria. Crucially, P. knowlesi may be the disease and experimental primate model for severe malaria. Plos One Publishing 2011 Article PeerReviewed text en http://ir.unimas.my/id/eprint/15806/1/Anti-Inflammatory%20Cytokines%20Predominate%20in%20Acute%20%28abstract%29.pdf Cox-Singh, J. and Balbir, Singh and Daneshvar, C. and Planche, Timothy and Parker-Williams, John and Sanjeev, Krishna (2011) Anti-Inflammatory Cytokines Predominate in Acute Human Plasmodium knowlesi Infections. PLoS ONE, 6 (6). ISSN 1932-6203 http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020541 http://dx.doi.org/10.1371/journal.pone.0020541 |
| spellingShingle | Q Science (General) Cox-Singh, J. Balbir, Singh Daneshvar, C. Planche, Timothy Parker-Williams, John Sanjeev, Krishna Anti-Inflammatory Cytokines Predominate in Acute Human Plasmodium knowlesi Infections |
| title | Anti-Inflammatory Cytokines Predominate in Acute Human Plasmodium knowlesi Infections |
| title_full | Anti-Inflammatory Cytokines Predominate in Acute Human Plasmodium knowlesi Infections |
| title_fullStr | Anti-Inflammatory Cytokines Predominate in Acute Human Plasmodium knowlesi Infections |
| title_full_unstemmed | Anti-Inflammatory Cytokines Predominate in Acute Human Plasmodium knowlesi Infections |
| title_short | Anti-Inflammatory Cytokines Predominate in Acute Human Plasmodium knowlesi Infections |
| title_sort | anti-inflammatory cytokines predominate in acute human plasmodium knowlesi infections |
| topic | Q Science (General) |
| url | http://ir.unimas.my/id/eprint/15806/ http://ir.unimas.my/id/eprint/15806/ http://ir.unimas.my/id/eprint/15806/ http://ir.unimas.my/id/eprint/15806/1/Anti-Inflammatory%20Cytokines%20Predominate%20in%20Acute%20%28abstract%29.pdf |