Susceptibility of human Plasmodium knowlesi infections to anti-malarials
Background: Evidence suggests that Plasmodium knowlesi malaria in Sarawak, Malaysian Borneo remains zoonotic, meaning anti-malarial drug resistance is unlikely to have developed in the absence of drug selection pressure. Therefore, adequate response to available anti-malarial treatments is assumed...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BioMed Central Ltd.
2013
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| Online Access: | http://ir.unimas.my/id/eprint/15795/ http://ir.unimas.my/id/eprint/15795/1/Susceptibility%20of%20human%20Plasmodium%20knowlesi%20%28abstract%29.pdf |
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| author | Farrah, A Fatih Staines, Henry M Siner, Angela Mohammed Atique, Ahmed Lu, Chan Woon Pasini, Erica M Kocken, Clemens HM Balbir, Singh Cox-Singh, J. Sanjeev, Krishna |
| author_facet | Farrah, A Fatih Staines, Henry M Siner, Angela Mohammed Atique, Ahmed Lu, Chan Woon Pasini, Erica M Kocken, Clemens HM Balbir, Singh Cox-Singh, J. Sanjeev, Krishna |
| author_sort | Farrah, A Fatih |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Background: Evidence suggests that Plasmodium knowlesi malaria in Sarawak, Malaysian Borneo remains zoonotic,
meaning anti-malarial drug resistance is unlikely to have developed in the absence of drug selection pressure.
Therefore, adequate response to available anti-malarial treatments is assumed.
Methods: Here the ex vivo sensitivity of human P. knowlesi isolates in Malaysian Borneo were studied, using a WHO schizont maturation assay modified to accommodate the quotidian life cycle of this parasite. The in vitro sensitivities of P. knowlesi H strain adapted from a primate infection to in vitro culture (by measuring the production of Plasmodium lactate dehydrogenase) were also examined together with some assays using Plasmodium falciparum and Plasmodium vivax.
Results: Plasmodium knowlesi is uniformly highly sensitive to artemisinins, variably and moderately sensitive to chloroquine, and less sensitive to mefloquine.
Conclusions: Taken together with reports of clinical failures when P. knowlesi is treated with mefloquine, the data suggest that caution is required if using mefloquine in prevention or treatment of P. knowlesi infections, until further studies are undertaken. |
| first_indexed | 2025-11-15T06:47:27Z |
| format | Article |
| id | unimas-15795 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:47:27Z |
| publishDate | 2013 |
| publisher | BioMed Central Ltd. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-157952017-04-04T00:48:18Z http://ir.unimas.my/id/eprint/15795/ Susceptibility of human Plasmodium knowlesi infections to anti-malarials Farrah, A Fatih Staines, Henry M Siner, Angela Mohammed Atique, Ahmed Lu, Chan Woon Pasini, Erica M Kocken, Clemens HM Balbir, Singh Cox-Singh, J. Sanjeev, Krishna R Medicine (General) Background: Evidence suggests that Plasmodium knowlesi malaria in Sarawak, Malaysian Borneo remains zoonotic, meaning anti-malarial drug resistance is unlikely to have developed in the absence of drug selection pressure. Therefore, adequate response to available anti-malarial treatments is assumed. Methods: Here the ex vivo sensitivity of human P. knowlesi isolates in Malaysian Borneo were studied, using a WHO schizont maturation assay modified to accommodate the quotidian life cycle of this parasite. The in vitro sensitivities of P. knowlesi H strain adapted from a primate infection to in vitro culture (by measuring the production of Plasmodium lactate dehydrogenase) were also examined together with some assays using Plasmodium falciparum and Plasmodium vivax. Results: Plasmodium knowlesi is uniformly highly sensitive to artemisinins, variably and moderately sensitive to chloroquine, and less sensitive to mefloquine. Conclusions: Taken together with reports of clinical failures when P. knowlesi is treated with mefloquine, the data suggest that caution is required if using mefloquine in prevention or treatment of P. knowlesi infections, until further studies are undertaken. BioMed Central Ltd. 2013 Article PeerReviewed text en http://ir.unimas.my/id/eprint/15795/1/Susceptibility%20of%20human%20Plasmodium%20knowlesi%20%28abstract%29.pdf Farrah, A Fatih and Staines, Henry M and Siner, Angela and Mohammed Atique, Ahmed and Lu, Chan Woon and Pasini, Erica M and Kocken, Clemens HM and Balbir, Singh and Cox-Singh, J. and Sanjeev, Krishna (2013) Susceptibility of human Plasmodium knowlesi infections to anti-malarials. Malaria Journal, 12 (425). ISSN 14752875 https://malariajournal.biomedcentral.com/articles/10.1186/1475-2875-12-425 DOI: 10.1186/1475-2875-12-425 |
| spellingShingle | R Medicine (General) Farrah, A Fatih Staines, Henry M Siner, Angela Mohammed Atique, Ahmed Lu, Chan Woon Pasini, Erica M Kocken, Clemens HM Balbir, Singh Cox-Singh, J. Sanjeev, Krishna Susceptibility of human Plasmodium knowlesi infections to anti-malarials |
| title | Susceptibility of human Plasmodium knowlesi infections to anti-malarials |
| title_full | Susceptibility of human Plasmodium knowlesi infections to anti-malarials |
| title_fullStr | Susceptibility of human Plasmodium knowlesi infections to anti-malarials |
| title_full_unstemmed | Susceptibility of human Plasmodium knowlesi infections to anti-malarials |
| title_short | Susceptibility of human Plasmodium knowlesi infections to anti-malarials |
| title_sort | susceptibility of human plasmodium knowlesi infections to anti-malarials |
| topic | R Medicine (General) |
| url | http://ir.unimas.my/id/eprint/15795/ http://ir.unimas.my/id/eprint/15795/ http://ir.unimas.my/id/eprint/15795/ http://ir.unimas.my/id/eprint/15795/1/Susceptibility%20of%20human%20Plasmodium%20knowlesi%20%28abstract%29.pdf |