Facile Synthesis of Curcumin-Loaded Starch-Maleate Nanoparticles
We have demonstrated the loading of curcumin onto starch maleate (SM) under mild conditions by mixing dissolved curcumin and SM nanoparticles separately in absolute ethanol and ethanol/aqueous (40 : 60 v/v), respectively. Curcumin-loaded starch-maleate (CurSM) nanoparticles were subsequently preci...
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2014
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/1572/ http://ir.unimas.my/id/eprint/1572/1/facile%20synthesis%20of%20curcumin%20loaded%20%28abstract%29.pdf |
| _version_ | 1848834790025854976 |
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| author | Pang, S.C. Tay, S.H. Chin, S.F. |
| author_facet | Pang, S.C. Tay, S.H. Chin, S.F. |
| author_sort | Pang, S.C. |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | We have demonstrated the loading of curcumin onto starch maleate (SM) under mild conditions by mixing dissolved curcumin and
SM nanoparticles separately in absolute ethanol and ethanol/aqueous (40 : 60 v/v), respectively. Curcumin-loaded starch-maleate
(CurSM) nanoparticles were subsequently precipitated from a homogeneous mixture of these solutions in absolute ethanol based
on the solvent exchange method. TEM analysis indicated that the diameters of CurSM nanoparticles were ranged between 30 nm
and 110 nm with a mean diameter of 50 nm. The curcumin loading capacity of SM as a function of loading duration was investigated
using the UV-visible spectrophotometer. The loading of curcumin onto SM increased rapidly initially with loading duration, and
the curcumin loading capacity of 15 mg/g was reached within 12 hours. CurSM nanoparticles exhibited substantially higher water
solubility of 6.0 × 10−2 mg/mL which is about 300 times higher than that of pure curcumin. With enhanced water solubility and
bioaccessibility of curcumin, the potential utility of CurSM nanoparticles in various biomedical applications is therefore envisaged. |
| first_indexed | 2025-11-15T05:57:34Z |
| format | Article |
| id | unimas-1572 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T05:57:34Z |
| publishDate | 2014 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-15722015-09-14T01:39:19Z http://ir.unimas.my/id/eprint/1572/ Facile Synthesis of Curcumin-Loaded Starch-Maleate Nanoparticles Pang, S.C. Tay, S.H. Chin, S.F. Q Science (General) QD Chemistry We have demonstrated the loading of curcumin onto starch maleate (SM) under mild conditions by mixing dissolved curcumin and SM nanoparticles separately in absolute ethanol and ethanol/aqueous (40 : 60 v/v), respectively. Curcumin-loaded starch-maleate (CurSM) nanoparticles were subsequently precipitated from a homogeneous mixture of these solutions in absolute ethanol based on the solvent exchange method. TEM analysis indicated that the diameters of CurSM nanoparticles were ranged between 30 nm and 110 nm with a mean diameter of 50 nm. The curcumin loading capacity of SM as a function of loading duration was investigated using the UV-visible spectrophotometer. The loading of curcumin onto SM increased rapidly initially with loading duration, and the curcumin loading capacity of 15 mg/g was reached within 12 hours. CurSM nanoparticles exhibited substantially higher water solubility of 6.0 × 10−2 mg/mL which is about 300 times higher than that of pure curcumin. With enhanced water solubility and bioaccessibility of curcumin, the potential utility of CurSM nanoparticles in various biomedical applications is therefore envisaged. Hindawi Publishing Corporation 2014 Article NonPeerReviewed text en http://ir.unimas.my/id/eprint/1572/1/facile%20synthesis%20of%20curcumin%20loaded%20%28abstract%29.pdf Pang, S.C. and Tay, S.H. and Chin, S.F. (2014) Facile Synthesis of Curcumin-Loaded Starch-Maleate Nanoparticles. Journal of Nanomaterials. http://dx.doi.org/10.1155/2014/824025 |
| spellingShingle | Q Science (General) QD Chemistry Pang, S.C. Tay, S.H. Chin, S.F. Facile Synthesis of Curcumin-Loaded Starch-Maleate Nanoparticles |
| title | Facile Synthesis of Curcumin-Loaded Starch-Maleate Nanoparticles |
| title_full | Facile Synthesis of Curcumin-Loaded Starch-Maleate Nanoparticles |
| title_fullStr | Facile Synthesis of Curcumin-Loaded Starch-Maleate Nanoparticles |
| title_full_unstemmed | Facile Synthesis of Curcumin-Loaded Starch-Maleate Nanoparticles |
| title_short | Facile Synthesis of Curcumin-Loaded Starch-Maleate Nanoparticles |
| title_sort | facile synthesis of curcumin-loaded starch-maleate nanoparticles |
| topic | Q Science (General) QD Chemistry |
| url | http://ir.unimas.my/id/eprint/1572/ http://ir.unimas.my/id/eprint/1572/ http://ir.unimas.my/id/eprint/1572/1/facile%20synthesis%20of%20curcumin%20loaded%20%28abstract%29.pdf |