Synthesis and antimicrobial studies of hydroxylated chalcone derivatives with variable chain length
A series of (E)-1-(4-alkyloxyphenyl)-3-(hydroxyphenyl)-prop-2-en-1-one have been successfully synthesised via Claisen–Schmidt condensation. The synthesised chalcone derivatives consisted of hydroxyl groups at either ortho, meta or para position and differed in the length of the alkyl groups, CnH...
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| Format: | Article |
| Language: | English |
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Taylor & Francis
2012
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| Online Access: | http://ir.unimas.my/id/eprint/15581/ http://ir.unimas.my/id/eprint/15581/1/zainab11.pdf |
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| author | Zainab, Ngaini Siti M., Haris Fadzillah Hasnain, Hussain |
| author_facet | Zainab, Ngaini Siti M., Haris Fadzillah Hasnain, Hussain |
| author_sort | Zainab, Ngaini |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | A series of (E)-1-(4-alkyloxyphenyl)-3-(hydroxyphenyl)-prop-2-en-1-one
have been successfully synthesised via Claisen–Schmidt condensation.
The synthesised chalcone derivatives consisted of hydroxyl groups at either
ortho, meta or para position and differed in the length of the alkyl groups,
CnH2nþ1, where n¼6, 10, 12 and 14. The structures of all compounds were
defined by elemental analysis, IR, 1H- and 13C-NMR. The antimicrobial
studies were carried out against wild-type Escherichia coli American Type
Culture Collection 8739 to evaluate the effect of the hydroxyl and the alkyl
groups of the synthesised chalcones. All the synthesised compounds have
shown significant antimicrobial activities. The optimum inhibition was
dependent on the position of the hydroxyl group as well as the length of
the alkyl chains. |
| first_indexed | 2025-11-15T06:46:43Z |
| format | Article |
| id | unimas-15581 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:46:43Z |
| publishDate | 2012 |
| publisher | Taylor & Francis |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-155812021-04-24T22:09:31Z http://ir.unimas.my/id/eprint/15581/ Synthesis and antimicrobial studies of hydroxylated chalcone derivatives with variable chain length Zainab, Ngaini Siti M., Haris Fadzillah Hasnain, Hussain Q Science (General) A series of (E)-1-(4-alkyloxyphenyl)-3-(hydroxyphenyl)-prop-2-en-1-one have been successfully synthesised via Claisen–Schmidt condensation. The synthesised chalcone derivatives consisted of hydroxyl groups at either ortho, meta or para position and differed in the length of the alkyl groups, CnH2nþ1, where n¼6, 10, 12 and 14. The structures of all compounds were defined by elemental analysis, IR, 1H- and 13C-NMR. The antimicrobial studies were carried out against wild-type Escherichia coli American Type Culture Collection 8739 to evaluate the effect of the hydroxyl and the alkyl groups of the synthesised chalcones. All the synthesised compounds have shown significant antimicrobial activities. The optimum inhibition was dependent on the position of the hydroxyl group as well as the length of the alkyl chains. Taylor & Francis 2012 Article PeerReviewed text en http://ir.unimas.my/id/eprint/15581/1/zainab11.pdf Zainab, Ngaini and Siti M., Haris Fadzillah and Hasnain, Hussain (2012) Synthesis and antimicrobial studies of hydroxylated chalcone derivatives with variable chain length. Natural Product Research, 26 (10). pp. 892-902. ISSN 1478-6427 http://dx.doi.org/10.1080/14786419.2010.502896 DOI: 10.1080/14786419.2010.502896 |
| spellingShingle | Q Science (General) Zainab, Ngaini Siti M., Haris Fadzillah Hasnain, Hussain Synthesis and antimicrobial studies of hydroxylated chalcone derivatives with variable chain length |
| title | Synthesis and antimicrobial studies of hydroxylated chalcone derivatives with variable chain length |
| title_full | Synthesis and antimicrobial studies of hydroxylated chalcone derivatives with variable chain length |
| title_fullStr | Synthesis and antimicrobial studies of hydroxylated chalcone derivatives with variable chain length |
| title_full_unstemmed | Synthesis and antimicrobial studies of hydroxylated chalcone derivatives with variable chain length |
| title_short | Synthesis and antimicrobial studies of hydroxylated chalcone derivatives with variable chain length |
| title_sort | synthesis and antimicrobial studies of hydroxylated chalcone derivatives with variable chain length |
| topic | Q Science (General) |
| url | http://ir.unimas.my/id/eprint/15581/ http://ir.unimas.my/id/eprint/15581/ http://ir.unimas.my/id/eprint/15581/ http://ir.unimas.my/id/eprint/15581/1/zainab11.pdf |