Bis-Thiourea bearing aryl and amino acids side Chains and their antibacterial activities
A series of symmetrical 1,3-bis thiourea 1a–e and 1,4-bis thiourea derivatives 2a–e have been successfully synthesized from the reactions of amines with 3-acetylbenzoyl isothiocyanate and 4-acetylbenzoyl isothiocyanate, respectively. All the synthesized compounds were characterized by FT-IR spectros...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group, LLC
2016
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| Online Access: | http://ir.unimas.my/id/eprint/15566/ http://ir.unimas.my/id/eprint/15566/1/BIS-THIOUREA.pdf |
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| author | Wan Sharifatun Handayani, Wan Zullkiplee Ainaa Nadiah, Abd Halim Zainab, Ngaini Maya Asyikin, Mohd Ariff Hasnain, Hussain |
| author_facet | Wan Sharifatun Handayani, Wan Zullkiplee Ainaa Nadiah, Abd Halim Zainab, Ngaini Maya Asyikin, Mohd Ariff Hasnain, Hussain |
| author_sort | Wan Sharifatun Handayani, Wan Zullkiplee |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | A series of symmetrical 1,3-bis thiourea 1a–e and 1,4-bis thiourea derivatives 2a–e have been successfully synthesized from the reactions of amines with 3-acetylbenzoyl isothiocyanate and 4-acetylbenzoyl isothiocyanate, respectively. All the synthesized compounds were characterized by FT-IR spectroscopy and 1H and 13C NMR spectroscopy. The compounds were screened for their antibacterial activity by turbidimetric method using gram-negative bacteria (E. coli ATCC 8739) using turbidimetric method. The newly synthesized bis-thiourea
derivatives bearing aryl side chains showed good antibacterial activity against E. coli. The
effect of the molecular structure of the synthesized compounds on the antibacterial activity is
discussed. |
| first_indexed | 2025-11-15T06:46:41Z |
| format | Article |
| id | unimas-15566 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:46:41Z |
| publishDate | 2016 |
| publisher | Taylor & Francis Group, LLC |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-155662023-06-19T08:08:13Z http://ir.unimas.my/id/eprint/15566/ Bis-Thiourea bearing aryl and amino acids side Chains and their antibacterial activities Wan Sharifatun Handayani, Wan Zullkiplee Ainaa Nadiah, Abd Halim Zainab, Ngaini Maya Asyikin, Mohd Ariff Hasnain, Hussain Q Science (General) QD Chemistry A series of symmetrical 1,3-bis thiourea 1a–e and 1,4-bis thiourea derivatives 2a–e have been successfully synthesized from the reactions of amines with 3-acetylbenzoyl isothiocyanate and 4-acetylbenzoyl isothiocyanate, respectively. All the synthesized compounds were characterized by FT-IR spectroscopy and 1H and 13C NMR spectroscopy. The compounds were screened for their antibacterial activity by turbidimetric method using gram-negative bacteria (E. coli ATCC 8739) using turbidimetric method. The newly synthesized bis-thiourea derivatives bearing aryl side chains showed good antibacterial activity against E. coli. The effect of the molecular structure of the synthesized compounds on the antibacterial activity is discussed. Taylor & Francis Group, LLC 2016 Article PeerReviewed text en http://ir.unimas.my/id/eprint/15566/1/BIS-THIOUREA.pdf Wan Sharifatun Handayani, Wan Zullkiplee and Ainaa Nadiah, Abd Halim and Zainab, Ngaini and Maya Asyikin, Mohd Ariff and Hasnain, Hussain (2016) Bis-Thiourea bearing aryl and amino acids side Chains and their antibacterial activities. Phosphorus Sulfur and Silicon and the Related Elements, 189 (6). ISSN 1042-6507 https://www.researchgate.net/publication/263286084_Bis-Thiourea_Bearing_Aryl_and_Amino_Acids_Side_Chains_and_Their_Antibacterial_Activities DOI: 10.1080/10426507.2013.858250 |
| spellingShingle | Q Science (General) QD Chemistry Wan Sharifatun Handayani, Wan Zullkiplee Ainaa Nadiah, Abd Halim Zainab, Ngaini Maya Asyikin, Mohd Ariff Hasnain, Hussain Bis-Thiourea bearing aryl and amino acids side Chains and their antibacterial activities |
| title | Bis-Thiourea bearing aryl and amino acids side
Chains and their antibacterial activities |
| title_full | Bis-Thiourea bearing aryl and amino acids side
Chains and their antibacterial activities |
| title_fullStr | Bis-Thiourea bearing aryl and amino acids side
Chains and their antibacterial activities |
| title_full_unstemmed | Bis-Thiourea bearing aryl and amino acids side
Chains and their antibacterial activities |
| title_short | Bis-Thiourea bearing aryl and amino acids side
Chains and their antibacterial activities |
| title_sort | bis-thiourea bearing aryl and amino acids side
chains and their antibacterial activities |
| topic | Q Science (General) QD Chemistry |
| url | http://ir.unimas.my/id/eprint/15566/ http://ir.unimas.my/id/eprint/15566/ http://ir.unimas.my/id/eprint/15566/ http://ir.unimas.my/id/eprint/15566/1/BIS-THIOUREA.pdf |