Fabrication of cellulose aerogel from sugarcane bagasse as drug delivery carriers
Currently most of the aerogel-based drug delivery carriers are made from non-biodegradable materials, such as silica. In this study, highly porous cellulose aerogels with Brunauer-Emmett-Teller (BET) surface areas that varied between 22 m2 g-1 and 525 m2 g-1 were prepared from a sugarcane bagasse ce...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universiti Sains Malaysia
2016
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/15302/ http://ir.unimas.my/id/eprint/15302/2/Fabrication%20of%20Cellulose%20-%20Copy.pdf |
| Summary: | Currently most of the aerogel-based drug delivery carriers are made from non-biodegradable materials, such as silica. In this study, highly porous cellulose aerogels with Brunauer-Emmett-Teller (BET) surface areas that varied between 22 m2 g-1 and 525 m2 g-1 were prepared from a sugarcane bagasse cellulose solution of various concentrations. The potential utility of cellulose aerogels as controlled release carriers was evaluated by loading methylene blue (MB) as a model hydrophilic drug. The MB loading capacity and release kinetic profiles of cellulose aerogels were observed to be substantially influenced by their BET surface areas. Under optimum conditions, a maximum loading capacity of 6.4 mg MB mg-1 cellulose aerogel was achieved with sustained release of MB from cellulose aerogels at physiological pH over a period of 23 h |
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