Environmentally Benign Syntheses and Characterization of 4- Aryldihydropyrimidin-2(1H)-ones
A general, simple, efficient, cost-effective and environmental benign procedure for the syntheses of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones (DHPMs) has been developed. The reaction is efficiently catalysed by using various amino acids viz., glycine, L-proline, L-cysteine, leucine and tryptophan. Rea...
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| Format: | Article |
| Language: | English |
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EDP Sciences
2016
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| Online Access: | http://ir.unimas.my/id/eprint/15184/ http://ir.unimas.my/id/eprint/15184/1/Syed.pdf |
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| author | Syed Salman, Shafqat Amir Azam, Khan Misbahulain, Khan Kuan, Nicholas Hoo Tien Mohd Syahmi, Jamaludin Pang, Suh Cem |
| author_facet | Syed Salman, Shafqat Amir Azam, Khan Misbahulain, Khan Kuan, Nicholas Hoo Tien Mohd Syahmi, Jamaludin Pang, Suh Cem |
| author_sort | Syed Salman, Shafqat |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | A general, simple, efficient, cost-effective and environmental benign procedure for the syntheses of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones (DHPMs) has been developed. The reaction is efficiently catalysed by using various amino acids viz., glycine, L-proline, L-cysteine, leucine and tryptophan. Reactions give excellent yields under reflux conditions. The chemical structures of these compounds were identified by Fourier Transform-Infra Red Spectroscopy (FT-IR), Gas Chromatography-Mass Spectroscopy (GC-MS) and Nuclear Magnetic Resonance Spectroscopy (1H NMR). Physical parameters such as m.p., mixed m.p. as well as TLC also helped to characterize the expected products. The progress of the reaction time and purity was checked by TLC and the products were purified by recrystallization using ethyl acetate as a solvent. The synthesized molecule has numerous biological applications as it is anti-microbial, anti-inflammatory and anti-hypertensive in character |
| first_indexed | 2025-11-15T06:45:25Z |
| format | Article |
| id | unimas-15184 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:45:25Z |
| publishDate | 2016 |
| publisher | EDP Sciences |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-151842021-06-09T14:59:26Z http://ir.unimas.my/id/eprint/15184/ Environmentally Benign Syntheses and Characterization of 4- Aryldihydropyrimidin-2(1H)-ones Syed Salman, Shafqat Amir Azam, Khan Misbahulain, Khan Kuan, Nicholas Hoo Tien Mohd Syahmi, Jamaludin Pang, Suh Cem TJ Mechanical engineering and machinery A general, simple, efficient, cost-effective and environmental benign procedure for the syntheses of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones (DHPMs) has been developed. The reaction is efficiently catalysed by using various amino acids viz., glycine, L-proline, L-cysteine, leucine and tryptophan. Reactions give excellent yields under reflux conditions. The chemical structures of these compounds were identified by Fourier Transform-Infra Red Spectroscopy (FT-IR), Gas Chromatography-Mass Spectroscopy (GC-MS) and Nuclear Magnetic Resonance Spectroscopy (1H NMR). Physical parameters such as m.p., mixed m.p. as well as TLC also helped to characterize the expected products. The progress of the reaction time and purity was checked by TLC and the products were purified by recrystallization using ethyl acetate as a solvent. The synthesized molecule has numerous biological applications as it is anti-microbial, anti-inflammatory and anti-hypertensive in character EDP Sciences 2016-12-12 Article PeerReviewed text en http://ir.unimas.my/id/eprint/15184/1/Syed.pdf Syed Salman, Shafqat and Amir Azam, Khan and Misbahulain, Khan and Kuan, Nicholas Hoo Tien and Mohd Syahmi, Jamaludin and Pang, Suh Cem (2016) Environmentally Benign Syntheses and Characterization of 4- Aryldihydropyrimidin-2(1H)-ones. MATEC Web of Conferences, 87. ISSN 2261236X https://www.scopus.com/inward/record.uri?eid=2-s2.0-85009080515&doi=10.1051%2fmatecconf%2f20178702025&partnerID=40&md5=86554cb141737de40bb0d27e2a6d1e03 DOI: 10.1051/matecconf/20178702025 |
| spellingShingle | TJ Mechanical engineering and machinery Syed Salman, Shafqat Amir Azam, Khan Misbahulain, Khan Kuan, Nicholas Hoo Tien Mohd Syahmi, Jamaludin Pang, Suh Cem Environmentally Benign Syntheses and Characterization of 4- Aryldihydropyrimidin-2(1H)-ones |
| title | Environmentally Benign Syntheses and Characterization of 4- Aryldihydropyrimidin-2(1H)-ones |
| title_full | Environmentally Benign Syntheses and Characterization of 4- Aryldihydropyrimidin-2(1H)-ones |
| title_fullStr | Environmentally Benign Syntheses and Characterization of 4- Aryldihydropyrimidin-2(1H)-ones |
| title_full_unstemmed | Environmentally Benign Syntheses and Characterization of 4- Aryldihydropyrimidin-2(1H)-ones |
| title_short | Environmentally Benign Syntheses and Characterization of 4- Aryldihydropyrimidin-2(1H)-ones |
| title_sort | environmentally benign syntheses and characterization of 4- aryldihydropyrimidin-2(1h)-ones |
| topic | TJ Mechanical engineering and machinery |
| url | http://ir.unimas.my/id/eprint/15184/ http://ir.unimas.my/id/eprint/15184/ http://ir.unimas.my/id/eprint/15184/ http://ir.unimas.my/id/eprint/15184/1/Syed.pdf |