Synthesis And Characterization Of Bis Thiourea Derivatives Another Antibacterial Activity
Thiourea and its derivatives are well known as potent antibacterial and antifungal agents. This research focused on the synthesis of bis thiourea derivatives with two thiourea groups resulting from the reactions of 3-acetylbenzoyl isothiocyanate intermediate with appropriate amine group from certain...
| Main Author: | |
|---|---|
| Format: | Final Year Project Report / IMRAD |
| Language: | English English |
| Published: |
Universiti Malaysia Sarawak, (UNIMAS)
2011
|
| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/1505/ http://ir.unimas.my/id/eprint/1505/1/2012-02-prWanSHbWZ.pdf http://ir.unimas.my/id/eprint/1505/7/Wan%20Sharifatun%20ft.pdf |
| _version_ | 1848834774343352320 |
|---|---|
| author | Wan Zullkiplee, Wan Sharifatun Handayani |
| author_facet | Wan Zullkiplee, Wan Sharifatun Handayani |
| author_sort | Wan Zullkiplee, Wan Sharifatun Handayani |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Thiourea and its derivatives are well known as potent antibacterial and antifungal agents. This research focused on the synthesis of bis thiourea derivatives with two thiourea groups resulting from the reactions of 3-acetylbenzoyl isothiocyanate intermediate with appropriate amine group from certain amino acids and aniline. Five bis thiourea derivatives have been synthesized. The successfully synthesized compounds were characterized using FTIR, IH NMR and DC NMR and found to be in highly purity compound. Antibacterial assay was carried out using turbidimetric method against the growth of Escherichia Coliform sp. (E. coli). However, the result indicated that the newly synthesized bis thiourea derivatives showed poor antibacterial activity against E. coli. The effect of the structure of the investigated compounds on the antibacterial activity is discussed. |
| first_indexed | 2025-11-15T05:57:19Z |
| format | Final Year Project Report / IMRAD |
| id | unimas-1505 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T05:57:19Z |
| publishDate | 2011 |
| publisher | Universiti Malaysia Sarawak, (UNIMAS) |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-15052024-08-23T09:03:24Z http://ir.unimas.my/id/eprint/1505/ Synthesis And Characterization Of Bis Thiourea Derivatives Another Antibacterial Activity Wan Zullkiplee, Wan Sharifatun Handayani QR Microbiology Thiourea and its derivatives are well known as potent antibacterial and antifungal agents. This research focused on the synthesis of bis thiourea derivatives with two thiourea groups resulting from the reactions of 3-acetylbenzoyl isothiocyanate intermediate with appropriate amine group from certain amino acids and aniline. Five bis thiourea derivatives have been synthesized. The successfully synthesized compounds were characterized using FTIR, IH NMR and DC NMR and found to be in highly purity compound. Antibacterial assay was carried out using turbidimetric method against the growth of Escherichia Coliform sp. (E. coli). However, the result indicated that the newly synthesized bis thiourea derivatives showed poor antibacterial activity against E. coli. The effect of the structure of the investigated compounds on the antibacterial activity is discussed. Universiti Malaysia Sarawak, (UNIMAS) 2011 Final Year Project Report / IMRAD NonPeerReviewed text en http://ir.unimas.my/id/eprint/1505/1/2012-02-prWanSHbWZ.pdf text en http://ir.unimas.my/id/eprint/1505/7/Wan%20Sharifatun%20ft.pdf Wan Zullkiplee, Wan Sharifatun Handayani (2011) Synthesis And Characterization Of Bis Thiourea Derivatives Another Antibacterial Activity. [Final Year Project Report / IMRAD] (Unpublished) |
| spellingShingle | QR Microbiology Wan Zullkiplee, Wan Sharifatun Handayani Synthesis And Characterization Of Bis Thiourea Derivatives Another Antibacterial Activity |
| title | Synthesis And Characterization Of Bis Thiourea Derivatives Another Antibacterial Activity |
| title_full | Synthesis And Characterization Of Bis Thiourea Derivatives Another Antibacterial Activity |
| title_fullStr | Synthesis And Characterization Of Bis Thiourea Derivatives Another Antibacterial Activity |
| title_full_unstemmed | Synthesis And Characterization Of Bis Thiourea Derivatives Another Antibacterial Activity |
| title_short | Synthesis And Characterization Of Bis Thiourea Derivatives Another Antibacterial Activity |
| title_sort | synthesis and characterization of bis thiourea derivatives another antibacterial activity |
| topic | QR Microbiology |
| url | http://ir.unimas.my/id/eprint/1505/ http://ir.unimas.my/id/eprint/1505/1/2012-02-prWanSHbWZ.pdf http://ir.unimas.my/id/eprint/1505/7/Wan%20Sharifatun%20ft.pdf |