Synthesis, spectral characterization and biological activities of Organotin(IV) complexes with ortho-vanillin-2-hydrazinopyridine (VHP)
Five new organotin(IV) complexes of ortho-vanillin- 2-hydrazinopyridine hydrazone with formula [RnSn- Cl4–n(VHP)] [R = Me2, n = 2 (2); R = Ph2, n = 2 (3); R= nBu2, n = 2 (4); R = nBu, n = 2 (5) and R = 1, n = 0 (6)] have been synthesized by direct reaction of orthovanillin- 2-hydrazinopyridine...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
OJIC
2012
|
| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/14384/ http://ir.unimas.my/id/eprint/14384/1/Norrihan.pdf |
| _version_ | 1848837636707319808 |
|---|---|
| author | Norrihan, Sam Md. Abu, Affan Abdus, Salam Mohd Razip, Asaruddin |
| author_facet | Norrihan, Sam Md. Abu, Affan Abdus, Salam Mohd Razip, Asaruddin |
| author_sort | Norrihan, Sam |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Five new organotin(IV) complexes of ortho-vanillin-
2-hydrazinopyridine hydrazone with formula [RnSn-
Cl4–n(VHP)] [R = Me2, n = 2 (2); R = Ph2, n = 2 (3); R=
nBu2, n = 2 (4); R = nBu, n = 2 (5) and R = 1, n = 0 (6)]
have been synthesized by direct reaction of orthovanillin-
2-hydrazinopyridine hydrazone [(VHP), (1)],
base and organotin(IV) chloride(s) in absolute methanol.
The hydrazone ligand [(VHP), (1)] and its organotin(
IV) complexes (2-6) have been characterized by
UV-Visible, FT-IR and 1H NMR spectral studies.
Spectroscopic data suggested that in the complexes
(2-4), the ligand (1) acted as a neutral bidentate ligand
and is coordinated to the tin(IV) atom via the azomethine
nitrogen and pyridyl nitrogen atoms, whereas
the ligand (1) acted as a uninegative tridentate ligand
and coordinated to the tin(IV) atom through phenolic-
O, azomethine-N and pyridyl-N atoms in complexes
(5-6). The toxicity of the ligand (1) and its organotin
(IV) complexes (2-6) were determined against Artemia
salina. Organotin(IV) complexes showed moderate activity
against Artemia salina. The ligand (1) and its
organotin(IV) complexes (2-6) were also tested against
four types of bacteria namely Bacillus cereus, Staphylococcus
aureus, Escherichia coli and Enterobacter
aerogenes. All organotin(IV) complexes and the free
ligand (1) showed better antibacterial activities against
bacteria. Among the organotin(IV) complexes (2-6),
diphenyltin(IV) complex (3) showed higher activity
against the four types of bacteria. |
| first_indexed | 2025-11-15T06:42:49Z |
| format | Article |
| id | unimas-14384 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:42:49Z |
| publishDate | 2012 |
| publisher | OJIC |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-143842022-01-24T06:24:07Z http://ir.unimas.my/id/eprint/14384/ Synthesis, spectral characterization and biological activities of Organotin(IV) complexes with ortho-vanillin-2-hydrazinopyridine (VHP) Norrihan, Sam Md. Abu, Affan Abdus, Salam Mohd Razip, Asaruddin QD Chemistry Five new organotin(IV) complexes of ortho-vanillin- 2-hydrazinopyridine hydrazone with formula [RnSn- Cl4–n(VHP)] [R = Me2, n = 2 (2); R = Ph2, n = 2 (3); R= nBu2, n = 2 (4); R = nBu, n = 2 (5) and R = 1, n = 0 (6)] have been synthesized by direct reaction of orthovanillin- 2-hydrazinopyridine hydrazone [(VHP), (1)], base and organotin(IV) chloride(s) in absolute methanol. The hydrazone ligand [(VHP), (1)] and its organotin( IV) complexes (2-6) have been characterized by UV-Visible, FT-IR and 1H NMR spectral studies. Spectroscopic data suggested that in the complexes (2-4), the ligand (1) acted as a neutral bidentate ligand and is coordinated to the tin(IV) atom via the azomethine nitrogen and pyridyl nitrogen atoms, whereas the ligand (1) acted as a uninegative tridentate ligand and coordinated to the tin(IV) atom through phenolic- O, azomethine-N and pyridyl-N atoms in complexes (5-6). The toxicity of the ligand (1) and its organotin (IV) complexes (2-6) were determined against Artemia salina. Organotin(IV) complexes showed moderate activity against Artemia salina. The ligand (1) and its organotin(IV) complexes (2-6) were also tested against four types of bacteria namely Bacillus cereus, Staphylococcus aureus, Escherichia coli and Enterobacter aerogenes. All organotin(IV) complexes and the free ligand (1) showed better antibacterial activities against bacteria. Among the organotin(IV) complexes (2-6), diphenyltin(IV) complex (3) showed higher activity against the four types of bacteria. OJIC 2012 Article PeerReviewed text en http://ir.unimas.my/id/eprint/14384/1/Norrihan.pdf Norrihan, Sam and Md. Abu, Affan and Abdus, Salam and Mohd Razip, Asaruddin (2012) Synthesis, spectral characterization and biological activities of Organotin(IV) complexes with ortho-vanillin-2-hydrazinopyridine (VHP). Open Journal of Inorganic Chemistry, 2. pp. 22-27. ISSN 2161-7414 https://www.researchgate.net/publication/266593201_Synthesis_spectral_characterization_and_biological_activities_of_OrganotinIV_complexes_with_ortho-vanillin-2-hydrazinopyridine_VHP doi:10.4236/ojic.2012.22004 |
| spellingShingle | QD Chemistry Norrihan, Sam Md. Abu, Affan Abdus, Salam Mohd Razip, Asaruddin Synthesis, spectral characterization and biological activities of Organotin(IV) complexes with ortho-vanillin-2-hydrazinopyridine (VHP) |
| title | Synthesis, spectral characterization and biological
activities of Organotin(IV) complexes with ortho-vanillin-2-hydrazinopyridine (VHP) |
| title_full | Synthesis, spectral characterization and biological
activities of Organotin(IV) complexes with ortho-vanillin-2-hydrazinopyridine (VHP) |
| title_fullStr | Synthesis, spectral characterization and biological
activities of Organotin(IV) complexes with ortho-vanillin-2-hydrazinopyridine (VHP) |
| title_full_unstemmed | Synthesis, spectral characterization and biological
activities of Organotin(IV) complexes with ortho-vanillin-2-hydrazinopyridine (VHP) |
| title_short | Synthesis, spectral characterization and biological
activities of Organotin(IV) complexes with ortho-vanillin-2-hydrazinopyridine (VHP) |
| title_sort | synthesis, spectral characterization and biological
activities of organotin(iv) complexes with ortho-vanillin-2-hydrazinopyridine (vhp) |
| topic | QD Chemistry |
| url | http://ir.unimas.my/id/eprint/14384/ http://ir.unimas.my/id/eprint/14384/ http://ir.unimas.my/id/eprint/14384/ http://ir.unimas.my/id/eprint/14384/1/Norrihan.pdf |