Synthesis, spectral characterization and biological activities of Organotin(IV) complexes with ortho-vanillin-2-hydrazinopyridine (VHP)
Five new organotin(IV) complexes of ortho-vanillin- 2-hydrazinopyridine hydrazone with formula [RnSn- Cl4–n(VHP)] [R = Me2, n = 2 (2); R = Ph2, n = 2 (3); R= nBu2, n = 2 (4); R = nBu, n = 2 (5) and R = 1, n = 0 (6)] have been synthesized by direct reaction of orthovanillin- 2-hydrazinopyridine...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
OJIC
2012
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/14384/ http://ir.unimas.my/id/eprint/14384/1/Norrihan.pdf |
| Summary: | Five new organotin(IV) complexes of ortho-vanillin-
2-hydrazinopyridine hydrazone with formula [RnSn-
Cl4–n(VHP)] [R = Me2, n = 2 (2); R = Ph2, n = 2 (3); R=
nBu2, n = 2 (4); R = nBu, n = 2 (5) and R = 1, n = 0 (6)]
have been synthesized by direct reaction of orthovanillin-
2-hydrazinopyridine hydrazone [(VHP), (1)],
base and organotin(IV) chloride(s) in absolute methanol.
The hydrazone ligand [(VHP), (1)] and its organotin(
IV) complexes (2-6) have been characterized by
UV-Visible, FT-IR and 1H NMR spectral studies.
Spectroscopic data suggested that in the complexes
(2-4), the ligand (1) acted as a neutral bidentate ligand
and is coordinated to the tin(IV) atom via the azomethine
nitrogen and pyridyl nitrogen atoms, whereas
the ligand (1) acted as a uninegative tridentate ligand
and coordinated to the tin(IV) atom through phenolic-
O, azomethine-N and pyridyl-N atoms in complexes
(5-6). The toxicity of the ligand (1) and its organotin
(IV) complexes (2-6) were determined against Artemia
salina. Organotin(IV) complexes showed moderate activity
against Artemia salina. The ligand (1) and its
organotin(IV) complexes (2-6) were also tested against
four types of bacteria namely Bacillus cereus, Staphylococcus
aureus, Escherichia coli and Enterobacter
aerogenes. All organotin(IV) complexes and the free
ligand (1) showed better antibacterial activities against
bacteria. Among the organotin(IV) complexes (2-6),
diphenyltin(IV) complex (3) showed higher activity
against the four types of bacteria. |
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