Lupus pneumonitis as the initial presentation of systemic lupus erythematosus: Case series from a single institution
Objective The aim of this study was to examine the clinical features, treatment and outcome of systemic lupus erythematosus (SLE) patients in our centre who presented with lupus pneumonitis as the initial manifestation. Methods We performed a retrospective review of all patients who presented with l...
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| Format: | Article |
| Language: | English |
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SAGE Publications Ltd
2016
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| Online Access: | http://ir.unimas.my/id/eprint/14204/ http://ir.unimas.my/id/eprint/14204/1/Lupus-pneumonitis-as-the-initial-presentation-of-systemic-lupus-erythematosus-Case-series-from-a-single-institution_2016_Lupus.html |
| _version_ | 1848837594020839424 |
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| author | Wan, S. A. Teh, Chenglay Jobli, Ahmad Tirmizi |
| author_facet | Wan, S. A. Teh, Chenglay Jobli, Ahmad Tirmizi |
| author_sort | Wan, S. A. |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Objective The aim of this study was to examine the clinical features, treatment and outcome of systemic lupus erythematosus (SLE) patients in our centre who presented with lupus pneumonitis as the initial manifestation. Methods We performed a retrospective review of all patients who presented with lupus pneumonitis during the initial SLE manifestation from March 2006 to March 2015. Results There were a total of five patients in our study who presented with fever and cough as the main clinical features. All patients had pulmonary infiltrates on chest radiographs. High-resolution computed tomography, which was performed in two patients, showed ground glass opacities with patchy consolidations bilaterally. All patients received high-dose steroids, 80% received intravenous cyclophosphamide and 60% received intravenous immunoglobulin. Two patients died from severe lupus pneumonitis within 2 weeks of admission despite treatment with ventilation, steroids, cyclophosphamide and intravenous immunoglobulin. Conclusions Acute lupus pneumonitis is an uncommon presentation of SLE. Mortality in this case series is 40%. |
| first_indexed | 2025-11-15T06:42:08Z |
| format | Article |
| id | unimas-14204 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:42:08Z |
| publishDate | 2016 |
| publisher | SAGE Publications Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-142042021-06-04T07:27:59Z http://ir.unimas.my/id/eprint/14204/ Lupus pneumonitis as the initial presentation of systemic lupus erythematosus: Case series from a single institution Wan, S. A. Teh, Chenglay Jobli, Ahmad Tirmizi R Medicine (General) Objective The aim of this study was to examine the clinical features, treatment and outcome of systemic lupus erythematosus (SLE) patients in our centre who presented with lupus pneumonitis as the initial manifestation. Methods We performed a retrospective review of all patients who presented with lupus pneumonitis during the initial SLE manifestation from March 2006 to March 2015. Results There were a total of five patients in our study who presented with fever and cough as the main clinical features. All patients had pulmonary infiltrates on chest radiographs. High-resolution computed tomography, which was performed in two patients, showed ground glass opacities with patchy consolidations bilaterally. All patients received high-dose steroids, 80% received intravenous cyclophosphamide and 60% received intravenous immunoglobulin. Two patients died from severe lupus pneumonitis within 2 weeks of admission despite treatment with ventilation, steroids, cyclophosphamide and intravenous immunoglobulin. Conclusions Acute lupus pneumonitis is an uncommon presentation of SLE. Mortality in this case series is 40%. SAGE Publications Ltd 2016-11-01 Article PeerReviewed text en http://ir.unimas.my/id/eprint/14204/1/Lupus-pneumonitis-as-the-initial-presentation-of-systemic-lupus-erythematosus-Case-series-from-a-single-institution_2016_Lupus.html Wan, S. A. and Teh, Chenglay and Jobli, Ahmad Tirmizi (2016) Lupus pneumonitis as the initial presentation of systemic lupus erythematosus: Case series from a single institution. Lupus, 25 (13). pp. 1485-1490. ISSN 09612033 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84990176690&partnerID=40&md5=87e80fd79f6b074decae2d5f5b6523ae DOI: 10.1177/0961203316646461 |
| spellingShingle | R Medicine (General) Wan, S. A. Teh, Chenglay Jobli, Ahmad Tirmizi Lupus pneumonitis as the initial presentation of systemic lupus erythematosus: Case series from a single institution |
| title | Lupus pneumonitis as the initial presentation of systemic lupus erythematosus: Case series from a single institution |
| title_full | Lupus pneumonitis as the initial presentation of systemic lupus erythematosus: Case series from a single institution |
| title_fullStr | Lupus pneumonitis as the initial presentation of systemic lupus erythematosus: Case series from a single institution |
| title_full_unstemmed | Lupus pneumonitis as the initial presentation of systemic lupus erythematosus: Case series from a single institution |
| title_short | Lupus pneumonitis as the initial presentation of systemic lupus erythematosus: Case series from a single institution |
| title_sort | lupus pneumonitis as the initial presentation of systemic lupus erythematosus: case series from a single institution |
| topic | R Medicine (General) |
| url | http://ir.unimas.my/id/eprint/14204/ http://ir.unimas.my/id/eprint/14204/ http://ir.unimas.my/id/eprint/14204/ http://ir.unimas.my/id/eprint/14204/1/Lupus-pneumonitis-as-the-initial-presentation-of-systemic-lupus-erythematosus-Case-series-from-a-single-institution_2016_Lupus.html |